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Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan

Paclitaxel (Taxol®) is a natural drug isolated from Ta.xus Brevifolia. It has been successfully used for the cancer treatment, especially breast and ovarian cancer. However, it is highly lipophilic and poor water solubility. To overcome these problems, it was formulated with non-aqueous vehicle cont...

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Main Author: Adenan, Siti Muneerah
Format: Thesis
Language:English
Published: 2013
Subjects:
Drugs and their actions
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/109388/1/109388.PDF
https://ir.uitm.edu.my/id/eprint/109388/
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spelling my.uitm.ir.1093882025-01-25T07:09:58Z https://ir.uitm.edu.my/id/eprint/109388/ Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan Adenan, Siti Muneerah Drugs and their actions Pharmaceutical chemistry Paclitaxel (Taxol®) is a natural drug isolated from Ta.xus Brevifolia. It has been successfully used for the cancer treatment, especially breast and ovarian cancer. However, it is highly lipophilic and poor water solubility. To overcome these problems, it was formulated with non-aqueous vehicle containing Cremophor® EL, which consequently causes senous toxicity such as allergic reaction. Nowadays, nanotechnology had widely being exploited in anticancer research, and one of them is Paclitaxel. Development of new PTX formulation which gives better efficacy and fewer side effects becomes extremely urgent. Therefore, in this study, nanoparticle Polyacrylic acid-PEG-chitosan bound paclitaxel was developed and used as delivery system for PTX . The cytotoxicity of new formulation of paclitaxel was evaluated for in vitro anti­ tumour activity against MCF-7 cell lines by using SRB assay. The results from the present study demonstrated that nanoparticle Polyacrylic acid-PEG-chitosan bound paclitaxel developed cytotoxic effects against MC- 7 cells, although with high concentration compared to PTX. It also showed that the formulation alone also was able to act as anti-tumour agent. We did plan to test the novel formulation on the normal body cell, which are BJ cells in order to detect any negative impacts. However, the steps need to be terminated due to restriction of time. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109388/1/109388.PDF Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs and their actions
Pharmaceutical chemistry
spellingShingle Drugs and their actions
Pharmaceutical chemistry
Adenan, Siti Muneerah
Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
description Paclitaxel (Taxol®) is a natural drug isolated from Ta.xus Brevifolia. It has been successfully used for the cancer treatment, especially breast and ovarian cancer. However, it is highly lipophilic and poor water solubility. To overcome these problems, it was formulated with non-aqueous vehicle containing Cremophor® EL, which consequently causes senous toxicity such as allergic reaction. Nowadays, nanotechnology had widely being exploited in anticancer research, and one of them is Paclitaxel. Development of new PTX formulation which gives better efficacy and fewer side effects becomes extremely urgent. Therefore, in this study, nanoparticle Polyacrylic acid-PEG-chitosan bound paclitaxel was developed and used as delivery system for PTX . The cytotoxicity of new formulation of paclitaxel was evaluated for in vitro anti­ tumour activity against MCF-7 cell lines by using SRB assay. The results from the present study demonstrated that nanoparticle Polyacrylic acid-PEG-chitosan bound paclitaxel developed cytotoxic effects against MC- 7 cells, although with high concentration compared to PTX. It also showed that the formulation alone also was able to act as anti-tumour agent. We did plan to test the novel formulation on the normal body cell, which are BJ cells in order to detect any negative impacts. However, the steps need to be terminated due to restriction of time.
format Thesis
author Adenan, Siti Muneerah
author_facet Adenan, Siti Muneerah
author_sort Adenan, Siti Muneerah
title Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
title_short Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
title_full Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
title_fullStr Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
title_full_unstemmed Cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / Siti Muneerah Adenan
title_sort cytotoxic effect of paclitaxel loaded and surface coated polyacrylic acid-peg-chitosan based nanoparticles / siti muneerah adenan
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109388/1/109388.PDF
https://ir.uitm.edu.my/id/eprint/109388/
_version_ 1823097909063712768
score 13.235796

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