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Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli

Paclitaxel alone has developed novel approach activity against breast cancer treatment. Highly effective antineoplastic activity of paclitaxel allows it to activate cell apoptosis and necrosis by stabilizing the formation of microtubules and thus prevent cell division. This study were intended to fo...

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Main Author: Zairosli, Normaizatul Shafiqah
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/109316/1/109316.PDF
https://ir.uitm.edu.my/id/eprint/109316/
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spelling my.uitm.ir.1093162025-01-25T07:09:54Z https://ir.uitm.edu.my/id/eprint/109316/ Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli Zairosli, Normaizatul Shafiqah Pharmacopoeias Pharmaceutical chemistry Paclitaxel alone has developed novel approach activity against breast cancer treatment. Highly effective antineoplastic activity of paclitaxel allows it to activate cell apoptosis and necrosis by stabilizing the formation of microtubules and thus prevent cell division. This study were intended to formulated new formulation which is a combination of Paclitaxel and N - Vinylcaprolactam ( NVC ) and compared the cytotoxic effects between Paclitaxel alone and new formulation of Paclitaxel and N - Vinyl Caprolactam against human breast cancer lines, MCF - 7. The method that had been conducted were Sulphorhodamine B assay (SRB assay) in order to determine cytotoxicity activity by evaluate the level of IC50. Based on the result, for IC50 Paclitaxel was 6 µg/ml meanwhile IC50 for newly formulated Paclitaxel and N - Vinyl Caprolactam was 10.3 µg/ml. Interestingly, although ICso for newly formulated Paclitaxel and N - Vinyl Caprolactam was slightly higher compared to IC50 of Paclitaxel but they do have significant roles in reducing percentages of cell viability. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109316/1/109316.PDF Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Zairosli, Normaizatul Shafiqah
Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
description Paclitaxel alone has developed novel approach activity against breast cancer treatment. Highly effective antineoplastic activity of paclitaxel allows it to activate cell apoptosis and necrosis by stabilizing the formation of microtubules and thus prevent cell division. This study were intended to formulated new formulation which is a combination of Paclitaxel and N - Vinylcaprolactam ( NVC ) and compared the cytotoxic effects between Paclitaxel alone and new formulation of Paclitaxel and N - Vinyl Caprolactam against human breast cancer lines, MCF - 7. The method that had been conducted were Sulphorhodamine B assay (SRB assay) in order to determine cytotoxicity activity by evaluate the level of IC50. Based on the result, for IC50 Paclitaxel was 6 µg/ml meanwhile IC50 for newly formulated Paclitaxel and N - Vinyl Caprolactam was 10.3 µg/ml. Interestingly, although ICso for newly formulated Paclitaxel and N - Vinyl Caprolactam was slightly higher compared to IC50 of Paclitaxel but they do have significant roles in reducing percentages of cell viability.
format Thesis
author Zairosli, Normaizatul Shafiqah
author_facet Zairosli, Normaizatul Shafiqah
author_sort Zairosli, Normaizatul Shafiqah
title Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
title_short Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
title_full Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
title_fullStr Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
title_full_unstemmed Cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / Normaizatul Shafiqah Zairosli
title_sort cytotoxic effect of paclitaxel loaded and surface coated n-vinyl caprolactam / normaizatul shafiqah zairosli
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109316/1/109316.PDF
https://ir.uitm.edu.my/id/eprint/109316/
_version_ 1823097895728971776
score 13.235796

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