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Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin

Nowadays, the use of plastic material is increasing rapidly. BPA is one of the highest­ volume chemicals and is produced in excess of 6 billion pounds per year for use as the monomer that is polymerized to manufacture polycarbonate plastic food and beverage containers, the resin lining of metal cans...

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Main Author: Shaharruddin, Shazwani
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:https://ir.uitm.edu.my/id/eprint/109303/1/109303.PDF
https://ir.uitm.edu.my/id/eprint/109303/
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spelling my.uitm.ir.1093032025-01-23T16:01:47Z https://ir.uitm.edu.my/id/eprint/109303/ Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin Shaharruddin, Shazwani Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Nowadays, the use of plastic material is increasing rapidly. BPA is one of the highest­ volume chemicals and is produced in excess of 6 billion pounds per year for use as the monomer that is polymerized to manufacture polycarbonate plastic food and beverage containers, the resin lining of metal cans, dental sealants, and as an additive in a wide array of other products. Until recently, BPA had been considered to be a very weak environmental estrogen because of its low ER affinity and because in many bioassays, BPA can be 10,000- to I 00,000-fold less potent than estradiol. Therefore, this research is carried out to determine whether low dose of BPA can induce protein concentration changes. Our result showed that BPA can induce protein concentration changes in female rats but the trend is inconsistent. BPA also has effect on weight of animal study. All the BPA dose used in this study induce weight gain higher than positive control treatment. Our study also showed that when increasing dose of BPA were given to SD rats, the female reproductive organ such as uterine horn and ovaries will increase in weight. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109303/1/109303.PDF Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Shaharruddin, Shazwani
Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
description Nowadays, the use of plastic material is increasing rapidly. BPA is one of the highest­ volume chemicals and is produced in excess of 6 billion pounds per year for use as the monomer that is polymerized to manufacture polycarbonate plastic food and beverage containers, the resin lining of metal cans, dental sealants, and as an additive in a wide array of other products. Until recently, BPA had been considered to be a very weak environmental estrogen because of its low ER affinity and because in many bioassays, BPA can be 10,000- to I 00,000-fold less potent than estradiol. Therefore, this research is carried out to determine whether low dose of BPA can induce protein concentration changes. Our result showed that BPA can induce protein concentration changes in female rats but the trend is inconsistent. BPA also has effect on weight of animal study. All the BPA dose used in this study induce weight gain higher than positive control treatment. Our study also showed that when increasing dose of BPA were given to SD rats, the female reproductive organ such as uterine horn and ovaries will increase in weight.
format Thesis
author Shaharruddin, Shazwani
author_facet Shaharruddin, Shazwani
author_sort Shaharruddin, Shazwani
title Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
title_short Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
title_full Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
title_fullStr Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
title_full_unstemmed Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin
title_sort determination of protein concentration changes and body weight changes in females sprague-dawleys (sd) rats treated with different doses of bpa / shazwani shaharruddin
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109303/1/109303.PDF
https://ir.uitm.edu.my/id/eprint/109303/
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score 13.235796

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