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Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin

Paclitaxel is one of best anticancer drugs, which has excellent therapeutic effects against a wide spectrum of cancers. The formulation of paclitaxel used in the currently clinical administration includes Cremophor EL, which has been found to cause serious side effects. Nanoparticle formulation of p...

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Main Author: Zainal Abidin, Muhd Hazwan
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/109236/1/109236.PDF
https://ir.uitm.edu.my/id/eprint/109236/
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spelling my.uitm.ir.1092362025-02-21T23:51:43Z https://ir.uitm.edu.my/id/eprint/109236/ Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin Zainal Abidin, Muhd Hazwan Pharmacopoeias Pharmaceutical chemistry Paclitaxel is one of best anticancer drugs, which has excellent therapeutic effects against a wide spectrum of cancers. The formulation of paclitaxel used in the currently clinical administration includes Cremophor EL, which has been found to cause serious side effects. Nanoparticle formulation of paclitaxel may provide an ideal solution to overcome this problem and achieve a sustained chemotherapy. Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes nature of the carrier, particle size and size distribution, morphology, surfactant stabilizer according to the technique applied, drug loading ratio and encapsulation efficiency, and surface property, etc. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109236/1/109236.PDF Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Zainal Abidin, Muhd Hazwan
Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
description Paclitaxel is one of best anticancer drugs, which has excellent therapeutic effects against a wide spectrum of cancers. The formulation of paclitaxel used in the currently clinical administration includes Cremophor EL, which has been found to cause serious side effects. Nanoparticle formulation of paclitaxel may provide an ideal solution to overcome this problem and achieve a sustained chemotherapy. Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes nature of the carrier, particle size and size distribution, morphology, surfactant stabilizer according to the technique applied, drug loading ratio and encapsulation efficiency, and surface property, etc.
format Thesis
author Zainal Abidin, Muhd Hazwan
author_facet Zainal Abidin, Muhd Hazwan
author_sort Zainal Abidin, Muhd Hazwan
title Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
title_short Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
title_full Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
title_fullStr Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
title_full_unstemmed Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin
title_sort paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / muhd hazwan zainal abidin
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109236/1/109236.PDF
https://ir.uitm.edu.my/id/eprint/109236/
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score 13.239859

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