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Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli

The phenomenon of multidrug resistance (MDR) is associated with the over expression of P-glycoprotein (P-gp) at the target cell. P-gp responsible to efflux drugs out of the cell and reduce the accumulation of drugs thus decrease the therapeutic effect of these chemotherapy drugs. Triterpene glycosid...

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Main Author: Ramli, Nurliyana
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmaceutical technology
Online Access:https://ir.uitm.edu.my/id/eprint/109235/1/109235.PDF
https://ir.uitm.edu.my/id/eprint/109235/
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spelling my.uitm.ir.1092352025-01-23T15:36:50Z https://ir.uitm.edu.my/id/eprint/109235/ Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli Ramli, Nurliyana Pharmaceutical technology The phenomenon of multidrug resistance (MDR) is associated with the over expression of P-glycoprotein (P-gp) at the target cell. P-gp responsible to efflux drugs out of the cell and reduce the accumulation of drugs thus decrease the therapeutic effect of these chemotherapy drugs. Triterpene glycosides can be found mostly in sea cucumber and are shown to give cytotoxic activity against tumor and cancer cell. In this computational study, Autodock Vina was employed to study potential interactions between P­ glycoprotein and triterpene glycosides. Two triterpene glycosides derivatives, Intercedenside A and Intercedenside B are found to form hydrogen bond with Tyr 303 of P-gp. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109235/1/109235.PDF Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical technology
spellingShingle Pharmaceutical technology
Ramli, Nurliyana
Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
description The phenomenon of multidrug resistance (MDR) is associated with the over expression of P-glycoprotein (P-gp) at the target cell. P-gp responsible to efflux drugs out of the cell and reduce the accumulation of drugs thus decrease the therapeutic effect of these chemotherapy drugs. Triterpene glycosides can be found mostly in sea cucumber and are shown to give cytotoxic activity against tumor and cancer cell. In this computational study, Autodock Vina was employed to study potential interactions between P­ glycoprotein and triterpene glycosides. Two triterpene glycosides derivatives, Intercedenside A and Intercedenside B are found to form hydrogen bond with Tyr 303 of P-gp.
format Thesis
author Ramli, Nurliyana
author_facet Ramli, Nurliyana
author_sort Ramli, Nurliyana
title Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
title_short Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
title_full Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
title_fullStr Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
title_full_unstemmed Molecular docking study of triterpene glycosides and the mouse p-glycoprotein (MDR1/ABCB1) using autodock vina software / Nurliyana Ramli
title_sort molecular docking study of triterpene glycosides and the mouse p-glycoprotein (mdr1/abcb1) using autodock vina software / nurliyana ramli
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109235/1/109235.PDF
https://ir.uitm.edu.my/id/eprint/109235/
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score 13.239859

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