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Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir

Diabetes mellitus is a universal disease that affecting millions of people worldwide. Currently, the common agents used to control this disease are hypoglycemic drugs and insulin. Apparently, the use of these agents has many prominent side effects and complications. Search for a better alternative i...

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Main Author: Abd Nasir, Muhammad Ashraf
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/109197/1/109197.PDF
https://ir.uitm.edu.my/id/eprint/109197/
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spelling my.uitm.ir.1091972025-02-14T11:57:01Z https://ir.uitm.edu.my/id/eprint/109197/ Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir Abd Nasir, Muhammad Ashraf Pharmacopoeias Diabetes mellitus is a universal disease that affecting millions of people worldwide. Currently, the common agents used to control this disease are hypoglycemic drugs and insulin. Apparently, the use of these agents has many prominent side effects and complications. Search for a better alternative is a very appealing. The present study aims to investigate the potential of banana soft pith ethyl acetate extract of Musa paradisiaca as safer natural hypoglycaemic agent. Primary mouse embryonic fibroblast cell (3T3-Ll) was used in this study. Quantitative study of cell viability and qualitative study of morphological changes were examined. Both MIT 3- ( 4,5-dimethylthiazol-2-yl)-2,5-dimethyl tetrazolium bromide dye assay and acridine orange/propidium iodide (AO/PI) staining indicated a general decrease in the cell viability percentage and number of cell observed under confocal microscope towards all concentrations, except for 250µg/ml of the extract which minute increment in cell viability percentage. The above findings suggest that the banana soft pith ethyl acetate extract of Musa paradisiaca may exert potential hypoglycaemic action through lipolysis which required further investigations in the future. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109197/1/109197.PDF Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
spellingShingle Pharmacopoeias
Abd Nasir, Muhammad Ashraf
Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
description Diabetes mellitus is a universal disease that affecting millions of people worldwide. Currently, the common agents used to control this disease are hypoglycemic drugs and insulin. Apparently, the use of these agents has many prominent side effects and complications. Search for a better alternative is a very appealing. The present study aims to investigate the potential of banana soft pith ethyl acetate extract of Musa paradisiaca as safer natural hypoglycaemic agent. Primary mouse embryonic fibroblast cell (3T3-Ll) was used in this study. Quantitative study of cell viability and qualitative study of morphological changes were examined. Both MIT 3- ( 4,5-dimethylthiazol-2-yl)-2,5-dimethyl tetrazolium bromide dye assay and acridine orange/propidium iodide (AO/PI) staining indicated a general decrease in the cell viability percentage and number of cell observed under confocal microscope towards all concentrations, except for 250µg/ml of the extract which minute increment in cell viability percentage. The above findings suggest that the banana soft pith ethyl acetate extract of Musa paradisiaca may exert potential hypoglycaemic action through lipolysis which required further investigations in the future.
format Thesis
author Abd Nasir, Muhammad Ashraf
author_facet Abd Nasir, Muhammad Ashraf
author_sort Abd Nasir, Muhammad Ashraf
title Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
title_short Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
title_full Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
title_fullStr Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
title_full_unstemmed Antiproliferative properties of Musa paradisiaca cv (Awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3T3-L1) / Muhammad Ashraf Abd Nasir
title_sort antiproliferative properties of musa paradisiaca cv (awak) ethyl acetate towards primary mouse embryonic fibroblast cell (3t3-l1) / muhammad ashraf abd nasir
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109197/1/109197.PDF
https://ir.uitm.edu.my/id/eprint/109197/
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score 13.239859

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