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Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi

The use of poly(lactic-coglycolic acid) (PLGA) in the form of simvastatin (SIM) with porous PLGA microparticles (PMP) often results in an initial uncontrolled burst of drug release and compromised mechanical integrity. Addressing these limitations is crucial for enhancing the therapeutic efficacy of...

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Main Author: Mohd Rawi, Ahmad Fareez
Format: Thesis
Language:English
Published: 2024
Subjects:
RK Dentistry
Oral and dental anatomy and physiology
Online Access:https://ir.uitm.edu.my/id/eprint/108916/1/108916.pdf
https://ir.uitm.edu.my/id/eprint/108916/
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spelling my.uitm.ir.1089162025-01-08T03:05:32Z https://ir.uitm.edu.my/id/eprint/108916/ Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi Mohd Rawi, Ahmad Fareez RK Dentistry Oral and dental anatomy and physiology The use of poly(lactic-coglycolic acid) (PLGA) in the form of simvastatin (SIM) with porous PLGA microparticles (PMP) often results in an initial uncontrolled burst of drug release and compromised mechanical integrity. Addressing these limitations is crucial for enhancing the therapeutic efficacy of these delivery systems. Objective: This study aims to improve the structural, release, and mechanical properties of porous SIM/PMP by incorporating various polymers: chitosan (Chi), pectin (Pec), and pluronic F127 (F127). Methodology: Employing a modified double emulsion solvent evaporation method, two method modifications were tested. In Method Modification 1 (MM1), biopolymers were integrated into the internal aqueous phase, while Method Modification 2 (MM2) involved adding them to the external phase. The samples underwent lyophilization and were stored for analysis. Results: The study revealed that 1.0% Chi SIM/PMP (MM2) significantly reduced the initial burst release of SIM, maintaining a controlled release over 21 days, as confirmed by High-Performance Liquid Chromatography (HPLC). Additionally, pluronic F127 enhanced the compressive strength of the scaffolds, surpassing both pectin and chitosan. Conclusion: Pluronic F127, a synthetic block copolymer, was identified as the most effective biopolymer for augmenting the release and mechanical properties of SIM/PMP scaffolds. This research highlights the potential of specific biopolymers in overcoming the inherent limitations of porous SIM/PMP microparticles, paving the way for more efficient drug delivery systems. 2024 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/108916/1/108916.pdf Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi. (2024) Masters thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/108916.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RK Dentistry
Oral and dental anatomy and physiology
spellingShingle RK Dentistry
Oral and dental anatomy and physiology
Mohd Rawi, Ahmad Fareez
Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
description The use of poly(lactic-coglycolic acid) (PLGA) in the form of simvastatin (SIM) with porous PLGA microparticles (PMP) often results in an initial uncontrolled burst of drug release and compromised mechanical integrity. Addressing these limitations is crucial for enhancing the therapeutic efficacy of these delivery systems. Objective: This study aims to improve the structural, release, and mechanical properties of porous SIM/PMP by incorporating various polymers: chitosan (Chi), pectin (Pec), and pluronic F127 (F127). Methodology: Employing a modified double emulsion solvent evaporation method, two method modifications were tested. In Method Modification 1 (MM1), biopolymers were integrated into the internal aqueous phase, while Method Modification 2 (MM2) involved adding them to the external phase. The samples underwent lyophilization and were stored for analysis. Results: The study revealed that 1.0% Chi SIM/PMP (MM2) significantly reduced the initial burst release of SIM, maintaining a controlled release over 21 days, as confirmed by High-Performance Liquid Chromatography (HPLC). Additionally, pluronic F127 enhanced the compressive strength of the scaffolds, surpassing both pectin and chitosan. Conclusion: Pluronic F127, a synthetic block copolymer, was identified as the most effective biopolymer for augmenting the release and mechanical properties of SIM/PMP scaffolds. This research highlights the potential of specific biopolymers in overcoming the inherent limitations of porous SIM/PMP microparticles, paving the way for more efficient drug delivery systems.
format Thesis
author Mohd Rawi, Ahmad Fareez
author_facet Mohd Rawi, Ahmad Fareez
author_sort Mohd Rawi, Ahmad Fareez
title Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
title_short Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
title_full Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
title_fullStr Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
title_full_unstemmed Fabrication of simvastatin loaded porous PLGA scaffold: improving the mechanical strength for bone tissue engineering / Ahmad Fareez Mohd Rawi
title_sort fabrication of simvastatin loaded porous plga scaffold: improving the mechanical strength for bone tissue engineering / ahmad fareez mohd rawi
publishDate 2024
url https://ir.uitm.edu.my/id/eprint/108916/1/108916.pdf
https://ir.uitm.edu.my/id/eprint/108916/
_version_ 1821006459790426112
score 13.239859

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