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Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain

Chalcones are a group of natural compounds that have attracted much attention because of their varied pharmacological characteristics. The synthesis, and antioxidant properties of chalcones and their derivatives are the main subjects of this study. Four chalcone derivatives were synthesized by Clais...

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Main Author: Iskandar Zulkarnain, 'Insyirah
Format: Student Project
Language:English
Published: 2024
Subjects:
Physical and theoretical chemistry
Analytical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/107477/1/107477.pdf
https://ir.uitm.edu.my/id/eprint/107477/
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spelling my.uitm.ir.1074772024-12-11T04:43:20Z https://ir.uitm.edu.my/id/eprint/107477/ Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain Iskandar Zulkarnain, 'Insyirah Physical and theoretical chemistry Analytical chemistry Chalcones are a group of natural compounds that have attracted much attention because of their varied pharmacological characteristics. The synthesis, and antioxidant properties of chalcones and their derivatives are the main subjects of this study. Four chalcone derivatives were synthesized by Claisen-Schmidt condensation of suitable aromatic ketones or substituted aromatic ketones with benzaldehydes or substituted benzaldehydes. They were four derivatives of chalcones, namely 2-hydroxy-4’-bromochalcone, 2-hydroxy-4’-chlorochalcone, 4’-bromochalcone and 4’-chlorochalcone. Purification of the synthesized chemicals was achieved using recrystallization and column chromatography. The determination of the structure of synthesized compounds were done by its physical properties like melting point and TLC followed by spectroscopic analysis such as NMR and FTIR. The antioxidant capacity of synthesized chalcones was assessed. The results showed significant antioxidant activity, indicating that chalcones may be useful as naturally occurring antioxidants. Overall, this work emphasizes the synthesis, and antioxidant properties of chalcones, highlighting their potential for use in medicine and other therapeutic fields. Additional investigation into chalcone derivatives might result in the creation of innovative medications with improved effectiveness and fewer adverse effects. 2024-08 Student Project NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/107477/1/107477.pdf Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain. (2024) [Student Project] (Submitted)
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Physical and theoretical chemistry
Analytical chemistry
spellingShingle Physical and theoretical chemistry
Analytical chemistry
Iskandar Zulkarnain, 'Insyirah
Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
description Chalcones are a group of natural compounds that have attracted much attention because of their varied pharmacological characteristics. The synthesis, and antioxidant properties of chalcones and their derivatives are the main subjects of this study. Four chalcone derivatives were synthesized by Claisen-Schmidt condensation of suitable aromatic ketones or substituted aromatic ketones with benzaldehydes or substituted benzaldehydes. They were four derivatives of chalcones, namely 2-hydroxy-4’-bromochalcone, 2-hydroxy-4’-chlorochalcone, 4’-bromochalcone and 4’-chlorochalcone. Purification of the synthesized chemicals was achieved using recrystallization and column chromatography. The determination of the structure of synthesized compounds were done by its physical properties like melting point and TLC followed by spectroscopic analysis such as NMR and FTIR. The antioxidant capacity of synthesized chalcones was assessed. The results showed significant antioxidant activity, indicating that chalcones may be useful as naturally occurring antioxidants. Overall, this work emphasizes the synthesis, and antioxidant properties of chalcones, highlighting their potential for use in medicine and other therapeutic fields. Additional investigation into chalcone derivatives might result in the creation of innovative medications with improved effectiveness and fewer adverse effects.
format Student Project
author Iskandar Zulkarnain, 'Insyirah
author_facet Iskandar Zulkarnain, 'Insyirah
author_sort Iskandar Zulkarnain, 'Insyirah
title Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
title_short Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
title_full Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
title_fullStr Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
title_full_unstemmed Synthesis and characterize the antioxidant activities of chalcone derivatives / 'Insyirah Iskandar Zulkarnain
title_sort synthesis and characterize the antioxidant activities of chalcone derivatives / 'insyirah iskandar zulkarnain
publishDate 2024
url https://ir.uitm.edu.my/id/eprint/107477/1/107477.pdf
https://ir.uitm.edu.my/id/eprint/107477/
_version_ 1818838360638095360
score 13.223943

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