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Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil

The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving...

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Main Author: Jamil, Fatin Farhanah
Format: Thesis
Language:English
Published: 2009
Subjects:
Pharmaceutical industry
Online Access:https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF
https://ir.uitm.edu.my/id/eprint/107166/
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spelling my.uitm.ir.1071662024-12-10T23:08:03Z https://ir.uitm.edu.my/id/eprint/107166/ Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil Jamil, Fatin Farhanah Pharmaceutical industry The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving the objectives of our study, there are two particular steps involve which were primary screening of secondary metabolites and large scale production of secondary metabolites. Primary screening was done in order to check which fungi transform the most potential and abundant secondary metabolites from glycyrrhizic acid. After the first step was performed, Trichothecium roseum was chosen as the fungi of interest for the large scale production and we was able to identify few secondary metabolites generated from Trichothecium roseum from HPLC chromatogram observed. Our research however was limited to HPLC identification. Structural elucidation by NMR cannot be done because of time limitation. 2009 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil. (2009) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical industry
spellingShingle Pharmaceutical industry
Jamil, Fatin Farhanah
Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
description The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving the objectives of our study, there are two particular steps involve which were primary screening of secondary metabolites and large scale production of secondary metabolites. Primary screening was done in order to check which fungi transform the most potential and abundant secondary metabolites from glycyrrhizic acid. After the first step was performed, Trichothecium roseum was chosen as the fungi of interest for the large scale production and we was able to identify few secondary metabolites generated from Trichothecium roseum from HPLC chromatogram observed. Our research however was limited to HPLC identification. Structural elucidation by NMR cannot be done because of time limitation.
format Thesis
author Jamil, Fatin Farhanah
author_facet Jamil, Fatin Farhanah
author_sort Jamil, Fatin Farhanah
title Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_short Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_full Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_fullStr Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_full_unstemmed Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_sort microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through lcms and nmr / fatin farhanah jamil
publishDate 2009
url https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF
https://ir.uitm.edu.my/id/eprint/107166/
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score 13.223943

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