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PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan

Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles....

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Main Author: W. Hasan, Wan Nurul Huda
Format: Thesis
Language:English
Published: 2009
Subjects:
Pharmaceutical industry
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF
https://ir.uitm.edu.my/id/eprint/107029/
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spelling my.uitm.ir.1070292024-12-10T23:13:12Z https://ir.uitm.edu.my/id/eprint/107029/ PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan W. Hasan, Wan Nurul Huda Pharmaceutical industry Pharmaceutical chemistry Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles. To achieve this goal, using ibuprofen as drug carrier and 50:50 poly(d,lactide-co-glycolide) as polymer carrier, the study investigated first the influence of the following variables on blank nanoparticle characteristics: (I) hydrophile­ lipophile balance (HLB) of SE palmitate, (2) homogenizing speed and (3) homogenizing time. Results showed that particles characteristic were at best when using HLB 15 of SE at homogenizing speed and time (#I, 60 seconds). The later ibuprofen-loaded nanoparticles made using this optimal parameters revealed a relatively acceptable encapsulation efficiency more than 50%. In term of dug release, there was high initial burst release followed by the more constant release thereafter. This study may suggest that many options can be done in order to optimize the stability, particles characteristics of the nanoparticles as well as drug content and encapsulation efficiency which may be helpful in the development of nanoparticle system for parenteral delivery of drug, protein and gene medicine, by using SE as an alternative surfactant. 2009 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan. (2009) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical industry
Pharmaceutical chemistry
spellingShingle Pharmaceutical industry
Pharmaceutical chemistry
W. Hasan, Wan Nurul Huda
PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
description Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles. To achieve this goal, using ibuprofen as drug carrier and 50:50 poly(d,lactide-co-glycolide) as polymer carrier, the study investigated first the influence of the following variables on blank nanoparticle characteristics: (I) hydrophile­ lipophile balance (HLB) of SE palmitate, (2) homogenizing speed and (3) homogenizing time. Results showed that particles characteristic were at best when using HLB 15 of SE at homogenizing speed and time (#I, 60 seconds). The later ibuprofen-loaded nanoparticles made using this optimal parameters revealed a relatively acceptable encapsulation efficiency more than 50%. In term of dug release, there was high initial burst release followed by the more constant release thereafter. This study may suggest that many options can be done in order to optimize the stability, particles characteristics of the nanoparticles as well as drug content and encapsulation efficiency which may be helpful in the development of nanoparticle system for parenteral delivery of drug, protein and gene medicine, by using SE as an alternative surfactant.
format Thesis
author W. Hasan, Wan Nurul Huda
author_facet W. Hasan, Wan Nurul Huda
author_sort W. Hasan, Wan Nurul Huda
title PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_short PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_full PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_fullStr PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_full_unstemmed PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_sort plga nanoparticles for sustained release using sucrose ester as an alternative surfactant / wan nurul huda w. hasan
publishDate 2009
url https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF
https://ir.uitm.edu.my/id/eprint/107029/
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score 13.222552

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