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The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia

Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in...

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Main Author: Abd Karim, Siti Fatma
Format: Thesis
Language:English
Published: 2023
Subjects:
DNA. Deoxyribonucleic acids
QP Physiology
Online Access:https://ir.uitm.edu.my/id/eprint/106818/2/106818.pdf
https://ir.uitm.edu.my/id/eprint/106818/
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spelling my.uitm.ir.1068182024-12-04T14:27:38Z https://ir.uitm.edu.my/id/eprint/106818/ The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia Abd Karim, Siti Fatma DNA. Deoxyribonucleic acids QP Physiology Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in offspring and increase susceptibility to adverse effects of excessive trans fat diet (TFD) intake. In this study, we aimed to investigate the effect of prenatal BPA exposure with postnatal TFD intake on metabolic and biochemical parameters, pancreatic tissue histology, peroxisome proliferator-activated receptor γ (PPARγ) protein expression, and global DNA methylation expression on adult SD rat offspring. Eighteen pregnant rats were divided into three groups: control (CTL), vehicle tween 80 (VHC), and BPA (5 mg/kg/day) from pregnancy day (PD) 2 to PD 21. Their male rats offspring were then fed either with normal diet (ND) or TFD from postnatal week (PNW) 3 to PNW 14 and were divided into six groups; ND control group (CTLND), TFD control group (CTLTFD), ND vehicle control group (VHCND), TFD vehicle control group (VHCTFD), ND BPA exposed group (BPAND) and TFD BPA exposed group (BPATFD). In offspring, the physiological parameters including body weight, waist circumference, water, and food intake were measured weekly. 2023 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/106818/2/106818.pdf The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia. (2023) PhD thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/106818.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic DNA. Deoxyribonucleic acids
QP Physiology
spellingShingle DNA. Deoxyribonucleic acids
QP Physiology
Abd Karim, Siti Fatma
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
description Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in offspring and increase susceptibility to adverse effects of excessive trans fat diet (TFD) intake. In this study, we aimed to investigate the effect of prenatal BPA exposure with postnatal TFD intake on metabolic and biochemical parameters, pancreatic tissue histology, peroxisome proliferator-activated receptor γ (PPARγ) protein expression, and global DNA methylation expression on adult SD rat offspring. Eighteen pregnant rats were divided into three groups: control (CTL), vehicle tween 80 (VHC), and BPA (5 mg/kg/day) from pregnancy day (PD) 2 to PD 21. Their male rats offspring were then fed either with normal diet (ND) or TFD from postnatal week (PNW) 3 to PNW 14 and were divided into six groups; ND control group (CTLND), TFD control group (CTLTFD), ND vehicle control group (VHCND), TFD vehicle control group (VHCTFD), ND BPA exposed group (BPAND) and TFD BPA exposed group (BPATFD). In offspring, the physiological parameters including body weight, waist circumference, water, and food intake were measured weekly.
format Thesis
author Abd Karim, Siti Fatma
author_facet Abd Karim, Siti Fatma
author_sort Abd Karim, Siti Fatma
title The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
title_short The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
title_full The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
title_fullStr The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
title_full_unstemmed The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
title_sort effects of trans fat diet intake on metabolic parameters and dna methylation profile in male offspring of in-utero bba exposed rats / hala f. s. abulehia
publishDate 2023
url https://ir.uitm.edu.my/id/eprint/106818/2/106818.pdf
https://ir.uitm.edu.my/id/eprint/106818/
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score 13.222552

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