Staff View: Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]

Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]

Sinomenine, derived from Sinomenium acutum, has a chemical structure similar to morphine and shows potential for treating opioid addiction in mice. Despite claims of being nonaddictive, its safety and abuse potential remain underexplored. Conditioned place preference (CPP) approach was used to evalu...

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Main Authors:	Ma’arof, Nur Syamimi, Ali, Aida Azlina, Jayasingh Chellammal, Hanish Singh, Zulkifli, Muhammad Harith
Format:	Article
Language:	English
Published:	Faculty of Pharmacy 2024
Subjects:	Pharmaceutical industry
Online Access:	https://ir.uitm.edu.my/id/eprint/106753/1/106753.pdf https://ir.uitm.edu.my/id/eprint/106753/ http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
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id	my.uitm.ir.106753
record_format	eprints
spelling	my.uitm.ir.1067532024-12-02T10:59:15Z https://ir.uitm.edu.my/id/eprint/106753/ Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.] ijpnacs Ma’arof, Nur Syamimi Ali, Aida Azlina Jayasingh Chellammal, Hanish Singh Zulkifli, Muhammad Harith Pharmaceutical industry Sinomenine, derived from Sinomenium acutum, has a chemical structure similar to morphine and shows potential for treating opioid addiction in mice. Despite claims of being nonaddictive, its safety and abuse potential remain underexplored. Conditioned place preference (CPP) approach was used to evaluate sinomenine's rewarding properties. ICR mice were divided into five groups, receiving either saline, morphine (8 mg/kg), or sinomenine (50, 100, or 200 mg/kg) where each group was confined to the drug-paired compartments during conditioning phase. Alternately, mice received saline when confined in the saline-paired compartment. During pre-conditioning and post-conditioning phases, the time spent in the drug-paired compartment, the number of entries to the drug-paired compartment, and rearing behaviours to assess the rewarding properties. Mice conditioned with morphine showed a significant increase in time spent in the drug-paired compartment from pre-conditioning to post-conditioning, but no significant changes in the number of entries and rearing behaviours. For saline and all sinomenine groups, there were no significant differences in the time spent, number of entries, and rearing behaviours except for sinomenine 200 mg/kg group, which showed a significant increase in rearing behaviours indicating an increase in exploratory behaviours. This study suggests that sinomenine, at various doses, is less likely to produce rewarding effects, indicating low abuse potential. The observed increase in exploratory behaviours during post-conditioning with sinomenine 200 mg/kg warrants further investigation. Faculty of Pharmacy 2024-10 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/106753/1/106753.pdf Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]. (2024) International Journal of Pharmaceutical, Nutraceutical and Cosmetic Science (IJPNaCS) <https://ir.uitm.edu.my/view/publication/International_Journal_of_Pharmaceutical,_Nutraceutical_and_Cosmetic_Science_=28IJPNaCS=29/>, 7 (2). pp. 78-88. ISSN 2682-8146 http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
institution	Universiti Teknologi Mara
building	Tun Abdul Razak Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Mara
content_source	UiTM Institutional Repository
url_provider	http://ir.uitm.edu.my/
language	English
topic	Pharmaceutical industry
spellingShingle	Pharmaceutical industry Ma’arof, Nur Syamimi Ali, Aida Azlina Jayasingh Chellammal, Hanish Singh Zulkifli, Muhammad Harith Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
description	Sinomenine, derived from Sinomenium acutum, has a chemical structure similar to morphine and shows potential for treating opioid addiction in mice. Despite claims of being nonaddictive, its safety and abuse potential remain underexplored. Conditioned place preference (CPP) approach was used to evaluate sinomenine's rewarding properties. ICR mice were divided into five groups, receiving either saline, morphine (8 mg/kg), or sinomenine (50, 100, or 200 mg/kg) where each group was confined to the drug-paired compartments during conditioning phase. Alternately, mice received saline when confined in the saline-paired compartment. During pre-conditioning and post-conditioning phases, the time spent in the drug-paired compartment, the number of entries to the drug-paired compartment, and rearing behaviours to assess the rewarding properties. Mice conditioned with morphine showed a significant increase in time spent in the drug-paired compartment from pre-conditioning to post-conditioning, but no significant changes in the number of entries and rearing behaviours. For saline and all sinomenine groups, there were no significant differences in the time spent, number of entries, and rearing behaviours except for sinomenine 200 mg/kg group, which showed a significant increase in rearing behaviours indicating an increase in exploratory behaviours. This study suggests that sinomenine, at various doses, is less likely to produce rewarding effects, indicating low abuse potential. The observed increase in exploratory behaviours during post-conditioning with sinomenine 200 mg/kg warrants further investigation.
format	Article
author	Ma’arof, Nur Syamimi Ali, Aida Azlina Jayasingh Chellammal, Hanish Singh Zulkifli, Muhammad Harith
author_facet	Ma’arof, Nur Syamimi Ali, Aida Azlina Jayasingh Chellammal, Hanish Singh Zulkifli, Muhammad Harith
author_sort	Ma’arof, Nur Syamimi
title	Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
title_short	Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
title_full	Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
title_fullStr	Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
title_full_unstemmed	Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]
title_sort	revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (cpp) model in mice / nur syamimi ma’arof ... [et al.]
publisher	Faculty of Pharmacy
publishDate	2024
url	https://ir.uitm.edu.my/id/eprint/106753/1/106753.pdf https://ir.uitm.edu.my/id/eprint/106753/ http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
_version_	1817847369152069632
score	13.223943

Revisiting the rewarding properties and abuse potential of natural compound sinomenine using conditioned place preference (CPP) model in mice / Nur Syamimi Ma’arof ... [et al.]

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