Cover Image

Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor

Parkia speciosa Hassk. boasts numerous health benefits, yet its raw consumption may be inconvenient or unpalatable for many. To date, limited research has explored the development of Parkia speciosa Hassk. chewable tablets. This study uses regression analysis to analyse the impact of compaction pres...

Full description

Saved in:
Bibliographic Details
Main Authors: Bakaruddin, Faghira, Anuar, Mohd Shamsul, Mohd Nor, Mohd Zuhair
Format: Article
Language:English
Published: Faculty of Pharmacy 2024
Subjects:
Pharmaceutical industry
Online Access:https://ir.uitm.edu.my/id/eprint/106750/1/106750.pdf
https://ir.uitm.edu.my/id/eprint/106750/
http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.106750
record_format eprints
spelling my.uitm.ir.1067502024-12-02T08:34:27Z https://ir.uitm.edu.my/id/eprint/106750/ Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor ijpnacs Bakaruddin, Faghira Anuar, Mohd Shamsul Mohd Nor, Mohd Zuhair Pharmaceutical industry Parkia speciosa Hassk. boasts numerous health benefits, yet its raw consumption may be inconvenient or unpalatable for many. To date, limited research has explored the development of Parkia speciosa Hassk. chewable tablets. This study uses regression analysis to analyse the impact of compaction pressure and excipient compositions on the physical characteristics of these tablets. Various compositions of microcrystalline cellulose (MCC, MicroceLac® 100, Lot No.: L103155221) excipient and dried Parkia speciosa Hassk. powder underwent direct compaction at four compaction pressures (22.61, 37.68, 52.75, and 67.82 MPa), with friability and tensile strength measured to assess breakage resistance. The regression analyses were performed using the built-in regression analysis tools available in Microsoft Excel (Version 16.73 (23051401)). Both compaction variables significantly influenced tablet mechanical strength (p-values ≤ 0.05). Higher pressure and increased MCC excipient reduced friability, enhancing breakage resistance. The 44.11% MCC excipient formulation, compacted at 67.82 MPa, demonstrated the lowest friability and high tensile strength. The friability and tensile strength models demonstrate a strong to good fit to the data, with an Rsquared value of 86.48% and 63.77%, respectively. The coefficients' findings confirm the hypothesis, indicating that increased excipient composition and compaction pressure decrease friability and enhance tensile strength. This study's findings and predictive model are useful for expedited development and optimization of Parkia speciosa Hassk tablet formulation. Faculty of Pharmacy 2024-08 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/106750/1/106750.pdf Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor. (2024) International Journal of Pharmaceutical, Nutraceutical and Cosmetic Science (IJPNaCS) <https://ir.uitm.edu.my/view/publication/International_Journal_of_Pharmaceutical,_Nutraceutical_and_Cosmetic_Science_=28IJPNaCS=29/>, 7 (2). pp. 34-43. ISSN 2682-8146 http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical industry
spellingShingle Pharmaceutical industry
Bakaruddin, Faghira
Anuar, Mohd Shamsul
Mohd Nor, Mohd Zuhair
Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
description Parkia speciosa Hassk. boasts numerous health benefits, yet its raw consumption may be inconvenient or unpalatable for many. To date, limited research has explored the development of Parkia speciosa Hassk. chewable tablets. This study uses regression analysis to analyse the impact of compaction pressure and excipient compositions on the physical characteristics of these tablets. Various compositions of microcrystalline cellulose (MCC, MicroceLac® 100, Lot No.: L103155221) excipient and dried Parkia speciosa Hassk. powder underwent direct compaction at four compaction pressures (22.61, 37.68, 52.75, and 67.82 MPa), with friability and tensile strength measured to assess breakage resistance. The regression analyses were performed using the built-in regression analysis tools available in Microsoft Excel (Version 16.73 (23051401)). Both compaction variables significantly influenced tablet mechanical strength (p-values ≤ 0.05). Higher pressure and increased MCC excipient reduced friability, enhancing breakage resistance. The 44.11% MCC excipient formulation, compacted at 67.82 MPa, demonstrated the lowest friability and high tensile strength. The friability and tensile strength models demonstrate a strong to good fit to the data, with an Rsquared value of 86.48% and 63.77%, respectively. The coefficients' findings confirm the hypothesis, indicating that increased excipient composition and compaction pressure decrease friability and enhance tensile strength. This study's findings and predictive model are useful for expedited development and optimization of Parkia speciosa Hassk tablet formulation.
format Article
author Bakaruddin, Faghira
Anuar, Mohd Shamsul
Mohd Nor, Mohd Zuhair
author_facet Bakaruddin, Faghira
Anuar, Mohd Shamsul
Mohd Nor, Mohd Zuhair
author_sort Bakaruddin, Faghira
title Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
title_short Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
title_full Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
title_fullStr Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
title_full_unstemmed Evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / Faghira Bakaruddin, Mohd Shamsul Anuar and Mohd Zuhair Mohd Nor
title_sort evaluation of the effect of excipient content on the physical properties of parkia speciosa hassk. tablets through regression analysis / faghira bakaruddin, mohd shamsul anuar and mohd zuhair mohd nor
publisher Faculty of Pharmacy
publishDate 2024
url https://ir.uitm.edu.my/id/eprint/106750/1/106750.pdf
https://ir.uitm.edu.my/id/eprint/106750/
http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
_version_ 1817847368723202048
score 13.223943

Similar Items