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Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud

Carbamazepine is an anticonvulsant and mood stabilizing agent that used primarily in treatment epilepsy and bipolar disorder, as well as trigeminal neuralgia. Microbial transformation is an effective tool for the structural modification of bioactive natural and synthetic compounds. Its application i...

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Main Author: Mahmud, Nurfarahana Hafzan
Format: Thesis
Language:English
Published: 2009
Subjects:
Pharmaceutical industry
Online Access:https://ir.uitm.edu.my/id/eprint/106538/1/106538.PDF
https://ir.uitm.edu.my/id/eprint/106538/
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spelling my.uitm.ir.1065382024-12-17T17:25:45Z https://ir.uitm.edu.my/id/eprint/106538/ Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud Mahmud, Nurfarahana Hafzan Pharmaceutical industry Carbamazepine is an anticonvulsant and mood stabilizing agent that used primarily in treatment epilepsy and bipolar disorder, as well as trigeminal neuralgia. Microbial transformation is an effective tool for the structural modification of bioactive natural and synthetic compounds. Its application in asymmetric synthesis is increasing due to its versatility and ease. Thus, four months of study was carried out to analyze any biotransformation of Carbamazepine. In order to see the structure modification of bioactive compound using microorganisms, we investigated the metabolism of Carbamazepine (1), using Trichothecium roseum and Cunninghamella elegans. In this research, two-stage production of secondary metabolites were being employed which are primary screening and large scale production. TLC method was applied in order to do qualitative analysis of biotransformed products and HPLC was the major step that was used in identifies the presence of metabolites. On the basis of HPLC chromatogram, series of unique peaks produced, indicated biotransformation has taken place at both 6 and 12 days. Trichothecium roseum and Cunninghamella elegan biotransform Carbamazepine into various hydroxylated and oxidative metabolites. 2009 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/106538/1/106538.PDF Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud. (2009) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical industry
spellingShingle Pharmaceutical industry
Mahmud, Nurfarahana Hafzan
Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
description Carbamazepine is an anticonvulsant and mood stabilizing agent that used primarily in treatment epilepsy and bipolar disorder, as well as trigeminal neuralgia. Microbial transformation is an effective tool for the structural modification of bioactive natural and synthetic compounds. Its application in asymmetric synthesis is increasing due to its versatility and ease. Thus, four months of study was carried out to analyze any biotransformation of Carbamazepine. In order to see the structure modification of bioactive compound using microorganisms, we investigated the metabolism of Carbamazepine (1), using Trichothecium roseum and Cunninghamella elegans. In this research, two-stage production of secondary metabolites were being employed which are primary screening and large scale production. TLC method was applied in order to do qualitative analysis of biotransformed products and HPLC was the major step that was used in identifies the presence of metabolites. On the basis of HPLC chromatogram, series of unique peaks produced, indicated biotransformation has taken place at both 6 and 12 days. Trichothecium roseum and Cunninghamella elegan biotransform Carbamazepine into various hydroxylated and oxidative metabolites.
format Thesis
author Mahmud, Nurfarahana Hafzan
author_facet Mahmud, Nurfarahana Hafzan
author_sort Mahmud, Nurfarahana Hafzan
title Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
title_short Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
title_full Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
title_fullStr Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
title_full_unstemmed Fungal transformation of carbamazepine and study their metabolites through NMR and LCMS method / Nurfarahana Hafzan Mahmud
title_sort fungal transformation of carbamazepine and study their metabolites through nmr and lcms method / nurfarahana hafzan mahmud
publishDate 2009
url https://ir.uitm.edu.my/id/eprint/106538/1/106538.PDF
https://ir.uitm.edu.my/id/eprint/106538/
_version_ 1818838339199959040
score 13.226497

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