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Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu

Most of studies on molecular basis of weak D have been conducted in Europe, Africa and several countries in Asia. Prevalent of weak D types varies among countries and also populations. Weak D type 15 was predominant in Chinese population in China. Meanwhile, there is limited data regarding weak D ty...

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Main Author: Saptu, Tressa Gadung
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/101713/1/101713.pdf
https://ir.uitm.edu.my/id/eprint/101713/
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spelling my.uitm.ir.1017132024-09-12T16:11:30Z https://ir.uitm.edu.my/id/eprint/101713/ Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu Saptu, Tressa Gadung Most of studies on molecular basis of weak D have been conducted in Europe, Africa and several countries in Asia. Prevalent of weak D types varies among countries and also populations. Weak D type 15 was predominant in Chinese population in China. Meanwhile, there is limited data regarding weak D type in Chinese population in Malaysia. Therefore, present study was conducted to determine the weak D type in Chinese blood donors from National Blood Centre (NBC), Malaysia by molecular technique of polymerase chain reaction with specific sequence primer (PCR-SSP). A total of nine D-negative blood samples of Chinese blood donors collected from NBC were tested for Rh phenotypes, weak D phenotypes and weak D allele by using molecular technique of PCR-SSP. Rh phenotypes consist of of 4 (45%) of ce, 1 (11%) of Ce, 3 (33%) of Cce and 1 (11%) of cEe. Out of nine D-negative blood samples, two were positive for weak D phenotype. Weak D type 15 was identified from both samples that positive for weak D phenotypes. Cce and cEe were the Rh phenotypes that present with weak D type 15 samples. As a conclusion, weak D type 15 was identified from Chinese blood donors and it is the first type of weak D that observed in Malaysian Chinese. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/101713/1/101713.pdf Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu. (2016) Degree thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/101713.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Most of studies on molecular basis of weak D have been conducted in Europe, Africa and several countries in Asia. Prevalent of weak D types varies among countries and also populations. Weak D type 15 was predominant in Chinese population in China. Meanwhile, there is limited data regarding weak D type in Chinese population in Malaysia. Therefore, present study was conducted to determine the weak D type in Chinese blood donors from National Blood Centre (NBC), Malaysia by molecular technique of polymerase chain reaction with specific sequence primer (PCR-SSP). A total of nine D-negative blood samples of Chinese blood donors collected from NBC were tested for Rh phenotypes, weak D phenotypes and weak D allele by using molecular technique of PCR-SSP. Rh phenotypes consist of of 4 (45%) of ce, 1 (11%) of Ce, 3 (33%) of Cce and 1 (11%) of cEe. Out of nine D-negative blood samples, two were positive for weak D phenotype. Weak D type 15 was identified from both samples that positive for weak D phenotypes. Cce and cEe were the Rh phenotypes that present with weak D type 15 samples. As a conclusion, weak D type 15 was identified from Chinese blood donors and it is the first type of weak D that observed in Malaysian Chinese.
format Thesis
author Saptu, Tressa Gadung
spellingShingle Saptu, Tressa Gadung
Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
author_facet Saptu, Tressa Gadung
author_sort Saptu, Tressa Gadung
title Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
title_short Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
title_full Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
title_fullStr Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
title_full_unstemmed Molecular analysis of weak D type in chinese blood donor from National Blood Center, Malaysia / Tressa Gadung Saptu
title_sort molecular analysis of weak d type in chinese blood donor from national blood center, malaysia / tressa gadung saptu
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/101713/1/101713.pdf
https://ir.uitm.edu.my/id/eprint/101713/
_version_ 1811598237721690112
score 13.211869

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