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Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian

Hematopoietic progenitor stem cells obtained from the peripheral blood have been increasingly used primarily to treat patient with several malignant hematopoietic disorder. The success of the allogeneic transplantation is significantly dependent on the total CD34+ stem cell count which will determin...

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Main Author: Bahagian, Hazlina Diyana
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/101099/1/101099.pdf
https://ir.uitm.edu.my/id/eprint/101099/
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spelling my.uitm.ir.1010992024-08-27T17:12:28Z https://ir.uitm.edu.my/id/eprint/101099/ Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian Bahagian, Hazlina Diyana Hematopoietic progenitor stem cells obtained from the peripheral blood have been increasingly used primarily to treat patient with several malignant hematopoietic disorder. The success of the allogeneic transplantation is significantly dependent on the total CD34+ stem cell count which will determine the rate of the hematopoietic recovery and engraftment. This study was aimed to correlate the different doses of CD34+ stem cell with the period of engraftment. We compared 2 groups of patients based on the total CD34+ stem cell count infused with several parameters for engraftment. Group A consisted of 9 patients who were infused with < 5 x 106 cells/kg CD34+ stem cell and Group B had consisted of 53 patients infused with ≥ 5 x 106 cells/kg CD34+ stem cell. The number of days taken to reach the neutrophil count ≥ 0.5 x 109/L, platelet count of ≥ 50 x 1011/L and successful complete chimerism were documented. In total 62 patients with hematopoietic malignancies were assessed by comparing low versus high doses of CD34+ stem cell. The number of CD34+ stem cell count correlated with the rate of engraftment. Infusion of more than 5 x 106 cells/kg patients body weight of CD34+ stem cells was significantly associated with faster neutrophil engraftment (p= 0.002). However, other parameters such as platelet engraftment (p= 0.149) and complete chimerism period (p= 0.021) were not significantly influenced by the CD34+ stem cell count. Generally this study has shown that infusion of ≥ 5 x 106 cells/kg CD34+ stem cell seems to shorten the time to hematopoietic engraftment. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/101099/1/101099.pdf Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian. (2016) Degree thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/101099.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Hematopoietic progenitor stem cells obtained from the peripheral blood have been increasingly used primarily to treat patient with several malignant hematopoietic disorder. The success of the allogeneic transplantation is significantly dependent on the total CD34+ stem cell count which will determine the rate of the hematopoietic recovery and engraftment. This study was aimed to correlate the different doses of CD34+ stem cell with the period of engraftment. We compared 2 groups of patients based on the total CD34+ stem cell count infused with several parameters for engraftment. Group A consisted of 9 patients who were infused with < 5 x 106 cells/kg CD34+ stem cell and Group B had consisted of 53 patients infused with ≥ 5 x 106 cells/kg CD34+ stem cell. The number of days taken to reach the neutrophil count ≥ 0.5 x 109/L, platelet count of ≥ 50 x 1011/L and successful complete chimerism were documented. In total 62 patients with hematopoietic malignancies were assessed by comparing low versus high doses of CD34+ stem cell. The number of CD34+ stem cell count correlated with the rate of engraftment. Infusion of more than 5 x 106 cells/kg patients body weight of CD34+ stem cells was significantly associated with faster neutrophil engraftment (p= 0.002). However, other parameters such as platelet engraftment (p= 0.149) and complete chimerism period (p= 0.021) were not significantly influenced by the CD34+ stem cell count. Generally this study has shown that infusion of ≥ 5 x 106 cells/kg CD34+ stem cell seems to shorten the time to hematopoietic engraftment.
format Thesis
author Bahagian, Hazlina Diyana
spellingShingle Bahagian, Hazlina Diyana
Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
author_facet Bahagian, Hazlina Diyana
author_sort Bahagian, Hazlina Diyana
title Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
title_short Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
title_full Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
title_fullStr Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
title_full_unstemmed Correlation study of CD34+ stem cell count and engraftment period in allogeneic transplant patients in UKMMC / Hazlina Diyana Bahagian
title_sort correlation study of cd34+ stem cell count and engraftment period in allogeneic transplant patients in ukmmc / hazlina diyana bahagian
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/101099/1/101099.pdf
https://ir.uitm.edu.my/id/eprint/101099/
_version_ 1808976155330478080
score 13.211869

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