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Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam

ABSTRACT Flufenamic acid, a non-steroidal anti-inflammatory drug (NSAID) was successfully intercalated into Magnesium-Aluminum-layered double hydroxide (Mg/Al-LDH) and Zn-Al-layered double hydroxide (Zn/Al-LDH) by self-assembly method at concentration of 0.6 M flufenamic acid and molar ratio of Mg/Z...

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Main Author: Jadam, Monica Limau
Format: Thesis
Language:English
Published: 2018
Subjects:
R Medicine (General)
Online Access:https://ir.uitm.edu.my/id/eprint/100834/1/100834.pdf
https://ir.uitm.edu.my/id/eprint/100834/
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spelling my.uitm.ir.1008342024-09-17T04:18:11Z https://ir.uitm.edu.my/id/eprint/100834/ Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam Jadam, Monica Limau R Medicine (General) ABSTRACT Flufenamic acid, a non-steroidal anti-inflammatory drug (NSAID) was successfully intercalated into Magnesium-Aluminum-layered double hydroxide (Mg/Al-LDH) and Zn-Al-layered double hydroxide (Zn/Al-LDH) by self-assembly method at concentration of 0.6 M flufenamic acid and molar ratio of Mg/Zn:Al = 2. The nanocomposites were synthesized until reached their optimum pH to enhance the intercalation process. The optimum pH for Magnesium-Aluminum-flufenamic acid (Mg/Al-FA) is at pH10 and Zn-Al-flufenamic acid (Zn/Al-FA) is at pH7.5. Upon the successful intercalation of the drug, release profiles and the factors govern its release from their matrices into various aqueous media were determined. The relatively phase-pure with well-ordered layered nanohybrid materials were successfully synthesized by self-assembly method at optimum condition. Expansion of basal spacing was observed from 9.8 A in the Mg/Al-LDH to 23.5 A in the Mg/Al-FA-LDH and 8.9 A in the Zn/Al-LDH to 21.0 A in the Zn/Al-FA-LDH nanocomposite obtained from the analysis by using PXRD. The results were supported by the data obtained from the whole analysis using FTIR, TGA/DTG, UV-Vis, CHNS, ASAP and ICPAES. Controlled release study of the drug into the aqueous solutions of sodium carbonate solution, sodium chloride solution and saline solution were performed. The release of drug into the aqueous media is in the order of; sodium carbonate > sodium chloride > saline solution with the percentage release of 50%, 30% and 20% for Mg/Al-FA-LDH and 53%, 42% and 20% for Zn/Al-FA-LDH, respectively. The release profiles are best described by pseudo-second order kinetic model as shown by the regression values of about 1.0. The FA anion was successfully intercalated into Mg/Al-LDH and Zn/Al-LDH with the percentage loading of guest anions which are 63.37% and 63.40%, respectively. This study shows that the Mg/Al-LDH and Zn/AlLDH can be used as a matrix for controlled release formulation of FA drug. The release of FA from the matrix was found to be controlled by the anion in the release aqueous solution as well as the type of the release media. 2018 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/100834/1/100834.pdf Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam. (2018) Masters thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/100834.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Jadam, Monica Limau
Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
description ABSTRACT Flufenamic acid, a non-steroidal anti-inflammatory drug (NSAID) was successfully intercalated into Magnesium-Aluminum-layered double hydroxide (Mg/Al-LDH) and Zn-Al-layered double hydroxide (Zn/Al-LDH) by self-assembly method at concentration of 0.6 M flufenamic acid and molar ratio of Mg/Zn:Al = 2. The nanocomposites were synthesized until reached their optimum pH to enhance the intercalation process. The optimum pH for Magnesium-Aluminum-flufenamic acid (Mg/Al-FA) is at pH10 and Zn-Al-flufenamic acid (Zn/Al-FA) is at pH7.5. Upon the successful intercalation of the drug, release profiles and the factors govern its release from their matrices into various aqueous media were determined. The relatively phase-pure with well-ordered layered nanohybrid materials were successfully synthesized by self-assembly method at optimum condition. Expansion of basal spacing was observed from 9.8 A in the Mg/Al-LDH to 23.5 A in the Mg/Al-FA-LDH and 8.9 A in the Zn/Al-LDH to 21.0 A in the Zn/Al-FA-LDH nanocomposite obtained from the analysis by using PXRD. The results were supported by the data obtained from the whole analysis using FTIR, TGA/DTG, UV-Vis, CHNS, ASAP and ICPAES. Controlled release study of the drug into the aqueous solutions of sodium carbonate solution, sodium chloride solution and saline solution were performed. The release of drug into the aqueous media is in the order of; sodium carbonate > sodium chloride > saline solution with the percentage release of 50%, 30% and 20% for Mg/Al-FA-LDH and 53%, 42% and 20% for Zn/Al-FA-LDH, respectively. The release profiles are best described by pseudo-second order kinetic model as shown by the regression values of about 1.0. The FA anion was successfully intercalated into Mg/Al-LDH and Zn/Al-LDH with the percentage loading of guest anions which are 63.37% and 63.40%, respectively. This study shows that the Mg/Al-LDH and Zn/AlLDH can be used as a matrix for controlled release formulation of FA drug. The release of FA from the matrix was found to be controlled by the anion in the release aqueous solution as well as the type of the release media.
format Thesis
author Jadam, Monica Limau
author_facet Jadam, Monica Limau
author_sort Jadam, Monica Limau
title Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
title_short Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
title_full Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
title_fullStr Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
title_full_unstemmed Intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / Monica Limau Jadam
title_sort intercalation of flufenamic acid into magnesiumaluminum-layered double hydroxide and zincaluminum-layered double hydroxide for the formation of controlled release drugs / monica limau jadam
publishDate 2018
url https://ir.uitm.edu.my/id/eprint/100834/1/100834.pdf
https://ir.uitm.edu.my/id/eprint/100834/
_version_ 1811598178872459264
score 13.211869

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