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Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar

The influence of microwave irradiation on dissolution medium and its effect on dissolution profiles of sulfamerazine and sulfathizole were investigated. The dissolution medium was subjected to microwave irradiation at 80 W for 37.5 min, and 300W for 10 min. The profiles of drug dissolution in these...

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Main Author: Iskhandar, Azzakirah
Format: Thesis
Language:English
Published: 2007
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:https://ir.uitm.edu.my/id/eprint/100070/1/100070.PDF
https://ir.uitm.edu.my/id/eprint/100070/
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spelling my.uitm.ir.1000702024-08-27T18:11:24Z https://ir.uitm.edu.my/id/eprint/100070/ Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar Iskhandar, Azzakirah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The influence of microwave irradiation on dissolution medium and its effect on dissolution profiles of sulfamerazine and sulfathizole were investigated. The dissolution medium was subjected to microwave irradiation at 80 W for 37.5 min, and 300W for 10 min. The profiles of drug dissolution in these media were compared to the untreated counterpart by drug dissolution testing, drug solubility, media pl-I, temperature, conductivity, UY and FTIR spectroscopy analysis. The irradiation of microwave was found to exert varying effects on the dissolution medium. Generally, the treatment of dissolution medium by microwave at 80 and 300W led to changes in pl-I, conductivity and mobility of water molecules. It appeared that the dissolution medium gained a higher degree of mobility upon its treatment by microwave thus leading to an increase in extent of sulfamerazine and sulfathiazole dissolution. 2007 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/100070/1/100070.PDF Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar. (2007) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Iskhandar, Azzakirah
Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
description The influence of microwave irradiation on dissolution medium and its effect on dissolution profiles of sulfamerazine and sulfathizole were investigated. The dissolution medium was subjected to microwave irradiation at 80 W for 37.5 min, and 300W for 10 min. The profiles of drug dissolution in these media were compared to the untreated counterpart by drug dissolution testing, drug solubility, media pl-I, temperature, conductivity, UY and FTIR spectroscopy analysis. The irradiation of microwave was found to exert varying effects on the dissolution medium. Generally, the treatment of dissolution medium by microwave at 80 and 300W led to changes in pl-I, conductivity and mobility of water molecules. It appeared that the dissolution medium gained a higher degree of mobility upon its treatment by microwave thus leading to an increase in extent of sulfamerazine and sulfathiazole dissolution.
format Thesis
author Iskhandar, Azzakirah
author_facet Iskhandar, Azzakirah
author_sort Iskhandar, Azzakirah
title Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
title_short Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
title_full Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
title_fullStr Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
title_full_unstemmed Influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / Azzakirah Iskhandar
title_sort influence of microwave on dissolution medium and its effect on sulfamerazine and sulfathiazole dissolution / azzakirah iskhandar
publishDate 2007
url https://ir.uitm.edu.my/id/eprint/100070/1/100070.PDF
https://ir.uitm.edu.my/id/eprint/100070/
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score 13.211869

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