New synthetic phenylquinazoline derivatives induce apoptosis by targeting the pro-survival members of the BCL-2 family

Chemo-resistant cancer cells acquire robust growth potential through cell signaling mechanisms such as the down-regulation of tumor suppressors and the up-regulation of pro-survival proteins, respectively. To overcome chemo-resistance of cancer, small molecule drugs that interact with the cell signa...

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Bibliographic Details
Main Authors: Simon, Samson Eugin, Usman, Ahmed *, Saad, Syed Muhammad, Ayaz, Anwar *, Khan, Khalid Mohammed, Tan, Ee Wern *, Tan, Kuan Onn *
Format: Article
Published: Elsevier 2022
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Online Access:http://eprints.sunway.edu.my/3113/
https://doi.org/10.1016/j.bmcl.2022.128731
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