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Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable phar...

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Main Authors:	Lum, Pei Teng, Mahendran, Sekar, Gan, Siew Hua, Jeyabalan, Srikanth, Bonam, Srinivasa Reddy, Nur Najihah, Izzati Mat Rani, Ku-Marina, Ku-Mahdzir, Seow, Lay Jing, Wu, Yuan Seng *, Vetriselvan, Subramaniyan, Fuloria, Neeraj Kumar, Fuloria, Shivkanya
Format:	Article
Published:	Elsevier 2022
Subjects:	QK Botany RC Internal medicine RS Pharmacy and materia medica
Online Access:	http://eprints.sunway.edu.my/3027/ https://doi.org/10.1016/j.sjbs.2021.11.016
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spelling	my.sunway.eprints.30272024-08-06T07:54:26Z http://eprints.sunway.edu.my/3027/ Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review Lum, Pei Teng Mahendran, Sekar Gan, Siew Hua Jeyabalan, Srikanth Bonam, Srinivasa Reddy Nur Najihah, Izzati Mat Rani Ku-Marina, Ku-Mahdzir Seow, Lay Jing Wu, Yuan Seng * Vetriselvan, Subramaniyan Fuloria, Neeraj Kumar Fuloria, Shivkanya QK Botany RC Internal medicine RS Pharmacy and materia medica There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans. Elsevier 2022 Article PeerReviewed Lum, Pei Teng and Mahendran, Sekar and Gan, Siew Hua and Jeyabalan, Srikanth and Bonam, Srinivasa Reddy and Nur Najihah, Izzati Mat Rani and Ku-Marina, Ku-Mahdzir and Seow, Lay Jing and Wu, Yuan Seng * and Vetriselvan, Subramaniyan and Fuloria, Neeraj Kumar and Fuloria, Shivkanya (2022) Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review. Saudi Journal of Biological Sciences, 29 (3). pp. 1530-1542. ISSN 1319-562X https://doi.org/10.1016/j.sjbs.2021.11.016 10.1016/j.sjbs.2021.11.016
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QK Botany RC Internal medicine RS Pharmacy and materia medica
spellingShingle	QK Botany RC Internal medicine RS Pharmacy and materia medica Lum, Pei Teng Mahendran, Sekar Gan, Siew Hua Jeyabalan, Srikanth Bonam, Srinivasa Reddy Nur Najihah, Izzati Mat Rani Ku-Marina, Ku-Mahdzir Seow, Lay Jing Wu, Yuan Seng * Vetriselvan, Subramaniyan Fuloria, Neeraj Kumar Fuloria, Shivkanya Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
description	There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.
format	Article
author	Lum, Pei Teng Mahendran, Sekar Gan, Siew Hua Jeyabalan, Srikanth Bonam, Srinivasa Reddy Nur Najihah, Izzati Mat Rani Ku-Marina, Ku-Mahdzir Seow, Lay Jing Wu, Yuan Seng * Vetriselvan, Subramaniyan Fuloria, Neeraj Kumar Fuloria, Shivkanya
author_facet	Lum, Pei Teng Mahendran, Sekar Gan, Siew Hua Jeyabalan, Srikanth Bonam, Srinivasa Reddy Nur Najihah, Izzati Mat Rani Ku-Marina, Ku-Mahdzir Seow, Lay Jing Wu, Yuan Seng * Vetriselvan, Subramaniyan Fuloria, Neeraj Kumar Fuloria, Shivkanya
author_sort	Lum, Pei Teng
title	Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
title_short	Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
title_full	Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
title_fullStr	Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
title_full_unstemmed	Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
title_sort	therapeutic potential of mangiferin against kidney disorders and its mechanism of action: a review
publisher	Elsevier
publishDate	2022
url	http://eprints.sunway.edu.my/3027/ https://doi.org/10.1016/j.sjbs.2021.11.016
_version_	1806692474698072064
score	13.211869

Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

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