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Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics

Dengue is one of the most frequently transmitted viral infections globally which creates a serious burden to the healthcare system in many countries in the tropical and subtropical regions. To date, no vaccine has demonstrated balanced protection against the four dengue serotypes. Dengvaxia as the o...

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Main Authors:	Mohd Ishtiaq Anasir, , Poh, Chit Laa
Format:	Article
Published:	Springer 2022
Subjects:	QP Physiology RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://eprints.sunway.edu.my/3019/ https://link.springer.com/article/10.1007/s00430-021-00726-1
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id	my.sunway.eprints.3019
record_format	eprints
spelling	my.sunway.eprints.30192024-08-06T07:00:43Z http://eprints.sunway.edu.my/3019/ Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics Mohd Ishtiaq Anasir, * Poh, Chit Laa * QP Physiology RC Internal medicine RM Therapeutics. Pharmacology Dengue is one of the most frequently transmitted viral infections globally which creates a serious burden to the healthcare system in many countries in the tropical and subtropical regions. To date, no vaccine has demonstrated balanced protection against the four dengue serotypes. Dengvaxia as the only vaccine that has been licensed for use in endemic areas has shown an increased risk in dengue-naïve vaccines to develop severe dengue. A crucial element in protection from dengue infection is the neutralizing antibody responses. Therefore, the identification of protective linear B-cell epitopes can guide vaccine design and facilitate the development of monoclonal antibodies as dengue therapeutics. This review summarizes the identification of dengue B-cell epitopes within the envelope (E) protein of dengue that can be incorporated into peptide vaccine constructs. These epitopes have been identified through approaches such as bioinformatics, three-dimensional structure analysis of antibody-dengue complexes, mutagenesis/alanine scanning and escape mutant studies. Additionally, the therapeutic potential of monoclonal antibodies targeting the E protein of dengue is reviewed. This can provide a basis for the design of future dengue therapies. Springer 2022 Article PeerReviewed Mohd Ishtiaq Anasir, * and Poh, Chit Laa * (2022) Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics. Medical Microbiology and Immunology, 211. pp. 1-18. ISSN 0300-8584 https://link.springer.com/article/10.1007/s00430-021-00726-1 10.1007/s00430-021-00726-1
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QP Physiology RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	QP Physiology RC Internal medicine RM Therapeutics. Pharmacology Mohd Ishtiaq Anasir, * Poh, Chit Laa * Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
description	Dengue is one of the most frequently transmitted viral infections globally which creates a serious burden to the healthcare system in many countries in the tropical and subtropical regions. To date, no vaccine has demonstrated balanced protection against the four dengue serotypes. Dengvaxia as the only vaccine that has been licensed for use in endemic areas has shown an increased risk in dengue-naïve vaccines to develop severe dengue. A crucial element in protection from dengue infection is the neutralizing antibody responses. Therefore, the identification of protective linear B-cell epitopes can guide vaccine design and facilitate the development of monoclonal antibodies as dengue therapeutics. This review summarizes the identification of dengue B-cell epitopes within the envelope (E) protein of dengue that can be incorporated into peptide vaccine constructs. These epitopes have been identified through approaches such as bioinformatics, three-dimensional structure analysis of antibody-dengue complexes, mutagenesis/alanine scanning and escape mutant studies. Additionally, the therapeutic potential of monoclonal antibodies targeting the E protein of dengue is reviewed. This can provide a basis for the design of future dengue therapies.
format	Article
author	Mohd Ishtiaq Anasir, * Poh, Chit Laa *
author_facet	Mohd Ishtiaq Anasir, * Poh, Chit Laa *
author_sort	Mohd Ishtiaq Anasir, *
title	Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
title_short	Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
title_full	Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
title_fullStr	Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
title_full_unstemmed	Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics
title_sort	discovery of b-cell epitopes for development of dengue vaccines and antibody therapeutics
publisher	Springer
publishDate	2022
url	http://eprints.sunway.edu.my/3019/ https://link.springer.com/article/10.1007/s00430-021-00726-1
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score	13.211869

Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics

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