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Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

Acanthamoeba is a genus of free-living amoebae, pervasively found in the environment. Most of its pathogenic species are the causative agent of sight-threatening Acanthamoeba keratitis and fatal granulomatous amoebic encephalitis. Despite the advancements in the field of chemotherapy, treating Acant...

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Main Authors:	Usman, Ahmed , Ayaz, Anwar , Ong, Seng Kai *, Areeba, Anwar, Khan, Naveed Ahmed
Format:	Article
Published:	Wiley 2022
Subjects:	QD Chemistry QL Zoology RC Internal medicine RE Ophthalmology
Online Access:	http://eprints.sunway.edu.my/2971/ https://doi.org/10.1002/med.21851
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id	my.sunway.eprints.2971
record_format	eprints
spelling	my.sunway.eprints.29712024-08-04T04:32:47Z http://eprints.sunway.edu.my/2971/ Applications of medicinal chemistry for drug discovery against Acanthamoeba infections Usman, Ahmed * Ayaz, Anwar * Ong, Seng Kai * Areeba, Anwar Khan, Naveed Ahmed QD Chemistry QL Zoology RC Internal medicine RE Ophthalmology Acanthamoeba is a genus of free-living amoebae, pervasively found in the environment. Most of its pathogenic species are the causative agent of sight-threatening Acanthamoeba keratitis and fatal granulomatous amoebic encephalitis. Despite the advancements in the field of chemotherapy, treating Acanthamoeba infections is still challenging due to incomplete knowledge of the complicated pathophysiology. In case of infection, the treatment regimen for the patients is often ineffective due to delayed diagnosis, poor specificity, and side-effects. Besides the resistance of Acanthamoeba cysts to most of the drugs, the recurrence of infection further complicates the recovery. Thus, it is necessary to develop an effective treatment which can eradicate these rare, but serious infections. Based on various computational and in vitro studies, it has been established that the synthetic scaffolds such as heterocyclic compounds may act as potential drug leads for the development of antiamoebic drugs. In this review, we report different classes of synthetic compounds especially heterocyclic compounds which have shown promising results against Acanthamoeba. Moreover, the antiamoebic activities of synthetic compounds with their possible mode of actions against Acanthamoeba, have been summarized and discussed in this review. Wiley 2022 Article PeerReviewed Usman, Ahmed * and Ayaz, Anwar * and Ong, Seng Kai * and Areeba, Anwar and Khan, Naveed Ahmed (2022) Applications of medicinal chemistry for drug discovery against Acanthamoeba infections. Medicinal Research Reviews, 42. pp. 462-512. ISSN 1098-1128 https://doi.org/10.1002/med.21851 10.1002/med.21851
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QD Chemistry QL Zoology RC Internal medicine RE Ophthalmology
spellingShingle	QD Chemistry QL Zoology RC Internal medicine RE Ophthalmology Usman, Ahmed * Ayaz, Anwar * Ong, Seng Kai * Areeba, Anwar Khan, Naveed Ahmed Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
description	Acanthamoeba is a genus of free-living amoebae, pervasively found in the environment. Most of its pathogenic species are the causative agent of sight-threatening Acanthamoeba keratitis and fatal granulomatous amoebic encephalitis. Despite the advancements in the field of chemotherapy, treating Acanthamoeba infections is still challenging due to incomplete knowledge of the complicated pathophysiology. In case of infection, the treatment regimen for the patients is often ineffective due to delayed diagnosis, poor specificity, and side-effects. Besides the resistance of Acanthamoeba cysts to most of the drugs, the recurrence of infection further complicates the recovery. Thus, it is necessary to develop an effective treatment which can eradicate these rare, but serious infections. Based on various computational and in vitro studies, it has been established that the synthetic scaffolds such as heterocyclic compounds may act as potential drug leads for the development of antiamoebic drugs. In this review, we report different classes of synthetic compounds especially heterocyclic compounds which have shown promising results against Acanthamoeba. Moreover, the antiamoebic activities of synthetic compounds with their possible mode of actions against Acanthamoeba, have been summarized and discussed in this review.
format	Article
author	Usman, Ahmed * Ayaz, Anwar * Ong, Seng Kai * Areeba, Anwar Khan, Naveed Ahmed
author_facet	Usman, Ahmed * Ayaz, Anwar * Ong, Seng Kai * Areeba, Anwar Khan, Naveed Ahmed
author_sort	Usman, Ahmed *
title	Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
title_short	Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
title_full	Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
title_fullStr	Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
title_full_unstemmed	Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
title_sort	applications of medicinal chemistry for drug discovery against acanthamoeba infections
publisher	Wiley
publishDate	2022
url	http://eprints.sunway.edu.my/2971/ https://doi.org/10.1002/med.21851
_version_	1806454421495742464
score	13.211869

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

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