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Nanovaccines against Viral Infectious Diseases

Infectious diseases have always been regarded as one of the greatest global threats for the last century. The current ongoing COVID-19 pandemic caused by SARS-CoV-2 is living proof that the world is still threatened by emerging infectious diseases. Morbidity and mortality rates of diseases caused by...

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Main Authors:	Heng, Wen Tzuen , Yew, Jia Sheng , Poh, Chit Laa *
Format:	Article
Published:	MDPI 2022
Subjects:	QR Microbiology RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://eprints.sunway.edu.my/2934/ https://doi.org/10.3390/pharmaceutics14122554
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id	my.sunway.eprints.2934
record_format	eprints
spelling	my.sunway.eprints.29342024-08-10T04:49:30Z http://eprints.sunway.edu.my/2934/ Nanovaccines against Viral Infectious Diseases Heng, Wen Tzuen * Yew, Jia Sheng * Poh, Chit Laa * QR Microbiology RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology Infectious diseases have always been regarded as one of the greatest global threats for the last century. The current ongoing COVID-19 pandemic caused by SARS-CoV-2 is living proof that the world is still threatened by emerging infectious diseases. Morbidity and mortality rates of diseases caused by Coronavirus have inflicted devastating social and economic outcomes. Undoubtedly, vaccination is the most effective method of eradicating infections and infectious diseases that have been eradicated by vaccinations, including Smallpox and Polio. To date, next-generation vaccine candidates with novel platforms are being approved for emergency use, such as the mRNA and viral vectored vaccines against SARS-CoV-2. Nanoparticle based vaccines are the perfect candidates as they demonstrated targeted antigen delivery, improved antigen presentation, and sustained antigen release while providing self-adjuvanting functions to stimulate potent immune responses. In this review, we discussed most of the recent nanovaccines that have found success in immunization and challenge studies in animal models in comparison with their naked vaccine counterparts. Nanovaccines that are currently in clinical trials are also reviewed. MDPI 2022 Article PeerReviewed Heng, Wen Tzuen * and Yew, Jia Sheng * and Poh, Chit Laa * (2022) Nanovaccines against Viral Infectious Diseases. Pharmaceutics, 14 (12). ISSN 1999-4923 https://doi.org/10.3390/pharmaceutics14122554 10.3390/pharmaceutics14122554
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QR Microbiology RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	QR Microbiology RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology Heng, Wen Tzuen * Yew, Jia Sheng * Poh, Chit Laa * Nanovaccines against Viral Infectious Diseases
description	Infectious diseases have always been regarded as one of the greatest global threats for the last century. The current ongoing COVID-19 pandemic caused by SARS-CoV-2 is living proof that the world is still threatened by emerging infectious diseases. Morbidity and mortality rates of diseases caused by Coronavirus have inflicted devastating social and economic outcomes. Undoubtedly, vaccination is the most effective method of eradicating infections and infectious diseases that have been eradicated by vaccinations, including Smallpox and Polio. To date, next-generation vaccine candidates with novel platforms are being approved for emergency use, such as the mRNA and viral vectored vaccines against SARS-CoV-2. Nanoparticle based vaccines are the perfect candidates as they demonstrated targeted antigen delivery, improved antigen presentation, and sustained antigen release while providing self-adjuvanting functions to stimulate potent immune responses. In this review, we discussed most of the recent nanovaccines that have found success in immunization and challenge studies in animal models in comparison with their naked vaccine counterparts. Nanovaccines that are currently in clinical trials are also reviewed.
format	Article
author	Heng, Wen Tzuen * Yew, Jia Sheng * Poh, Chit Laa *
author_facet	Heng, Wen Tzuen * Yew, Jia Sheng * Poh, Chit Laa *
author_sort	Heng, Wen Tzuen *
title	Nanovaccines against Viral Infectious Diseases
title_short	Nanovaccines against Viral Infectious Diseases
title_full	Nanovaccines against Viral Infectious Diseases
title_fullStr	Nanovaccines against Viral Infectious Diseases
title_full_unstemmed	Nanovaccines against Viral Infectious Diseases
title_sort	nanovaccines against viral infectious diseases
publisher	MDPI
publishDate	2022
url	http://eprints.sunway.edu.my/2934/ https://doi.org/10.3390/pharmaceutics14122554
_version_	1807053656861704192
score	13.211869

Nanovaccines against Viral Infectious Diseases

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