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Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression

Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 (HOXA13) and homeobox B13 (HOXB13) genes in Malaysian bladder cancer patients. The protein expression of HOXA13...

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Main Authors: Chin, Fee-Wai, Huzlinda, Hussin, Chau, De Ming, Ong, Teng Aik, Rosna, Yunus, Azad Hassan, Abdul Razack, Khatijah, Yusoff, Chan, Soon Choy, Abhi, Veerakumarasivam *
Format: Article
Language:English
Published: MDPI 2023
Subjects:
QH Natural history
QR Microbiology
R Medicine (General)
RC Internal medicine
Online Access:http://eprints.sunway.edu.my/2829/1/Abhi%20Veerakumarasivam_Differential%20protein%20expression%20patterns%20of%20HOXA13.pdf
http://eprints.sunway.edu.my/2829/
https://doi.org/10.3390/diagnostics13162636
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spelling my.sunway.eprints.28292024-07-16T03:21:21Z http://eprints.sunway.edu.my/2829/ Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression Chin, Fee-Wai Huzlinda, Hussin Chau, De Ming Ong, Teng Aik Rosna, Yunus Azad Hassan, Abdul Razack Khatijah, Yusoff Chan, Soon Choy Abhi, Veerakumarasivam * QH Natural history QR Microbiology R Medicine (General) RC Internal medicine Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 (HOXA13) and homeobox B13 (HOXB13) genes in Malaysian bladder cancer patients. The protein expression of HOXA13 and HOXB13 in formalin-fixed paraffin-embedded (FFPE) bladder cancer tissues was determined by immunohistochemistry (IHC) analysis. The association between HOXA13/HOXB13 protein expression and demographic/clinicopathological characteristics of the bladder cancer patients was determined by chi-square analysis. Approximately 63.6% of the bladder cancer tissues harbored high HOXA13 expression. High HOXA13 expression was significantly associated with non-muscle invasive bladder cancer, lower tumor grade, higher number of lymph node metastases, and recurrence risk. In contrast, low HOXB13 expression (including those with negative expression) was observed in 71.6% of the bladder cancer tissues analyzed. Low HOXB13 expression was significantly associated with muscle-invasive bladder cancer, higher tumor stage, tumor grade, and metastatic risk. Both HOXA13 and HOXB13 protein expression were found to be associated with bladder tumorigenesis. The putative oncogenic and tumor suppressive roles of HOXA13 and HOXB13, respectively, suggest their potential utility as biomarkers in bladder cancer. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2829/1/Abhi%20Veerakumarasivam_Differential%20protein%20expression%20patterns%20of%20HOXA13.pdf Chin, Fee-Wai and Huzlinda, Hussin and Chau, De Ming and Ong, Teng Aik and Rosna, Yunus and Azad Hassan, Abdul Razack and Khatijah, Yusoff and Chan, Soon Choy and Abhi, Veerakumarasivam * (2023) Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression. Diagnostics, 13 (16). ISSN 2075-4418 https://doi.org/10.3390/diagnostics13162636 10.3390/diagnostics13162636
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic QH Natural history
QR Microbiology
R Medicine (General)
RC Internal medicine
spellingShingle QH Natural history
QR Microbiology
R Medicine (General)
RC Internal medicine
Chin, Fee-Wai
Huzlinda, Hussin
Chau, De Ming
Ong, Teng Aik
Rosna, Yunus
Azad Hassan, Abdul Razack
Khatijah, Yusoff
Chan, Soon Choy
Abhi, Veerakumarasivam *
Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
description Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 (HOXA13) and homeobox B13 (HOXB13) genes in Malaysian bladder cancer patients. The protein expression of HOXA13 and HOXB13 in formalin-fixed paraffin-embedded (FFPE) bladder cancer tissues was determined by immunohistochemistry (IHC) analysis. The association between HOXA13/HOXB13 protein expression and demographic/clinicopathological characteristics of the bladder cancer patients was determined by chi-square analysis. Approximately 63.6% of the bladder cancer tissues harbored high HOXA13 expression. High HOXA13 expression was significantly associated with non-muscle invasive bladder cancer, lower tumor grade, higher number of lymph node metastases, and recurrence risk. In contrast, low HOXB13 expression (including those with negative expression) was observed in 71.6% of the bladder cancer tissues analyzed. Low HOXB13 expression was significantly associated with muscle-invasive bladder cancer, higher tumor stage, tumor grade, and metastatic risk. Both HOXA13 and HOXB13 protein expression were found to be associated with bladder tumorigenesis. The putative oncogenic and tumor suppressive roles of HOXA13 and HOXB13, respectively, suggest their potential utility as biomarkers in bladder cancer.
format Article
author Chin, Fee-Wai
Huzlinda, Hussin
Chau, De Ming
Ong, Teng Aik
Rosna, Yunus
Azad Hassan, Abdul Razack
Khatijah, Yusoff
Chan, Soon Choy
Abhi, Veerakumarasivam *
author_facet Chin, Fee-Wai
Huzlinda, Hussin
Chau, De Ming
Ong, Teng Aik
Rosna, Yunus
Azad Hassan, Abdul Razack
Khatijah, Yusoff
Chan, Soon Choy
Abhi, Veerakumarasivam *
author_sort Chin, Fee-Wai
title Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
title_short Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
title_full Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
title_fullStr Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
title_full_unstemmed Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
title_sort differential protein expression patterns of hoxa13 and hoxb13 are associated with bladder cancer progression
publisher MDPI
publishDate 2023
url http://eprints.sunway.edu.my/2829/1/Abhi%20Veerakumarasivam_Differential%20protein%20expression%20patterns%20of%20HOXA13.pdf
http://eprints.sunway.edu.my/2829/
https://doi.org/10.3390/diagnostics13162636
_version_ 1805893819064909824
score 13.211869

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