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Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?

Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and...

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Main Authors: Siddiqui, Ruqaiyyah, Ong, Timonthy Yu Yee *, Maciver, Sutherland, Khan, Naveed Ahmed
Format: Article
Published: Wiley 2023
Subjects:
QL Zoology
RC Internal medicine
RM Therapeutics. Pharmacology
Online Access:http://eprints.sunway.edu.my/2827/
https://doi.org/10.4155/tde-2023-0032
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spelling my.sunway.eprints.28272024-07-16T03:07:41Z http://eprints.sunway.edu.my/2827/ Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route? Siddiqui, Ruqaiyyah Ong, Timonthy Yu Yee * Maciver, Sutherland Khan, Naveed Ahmed QL Zoology RC Internal medicine RM Therapeutics. Pharmacology Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site. Wiley 2023 Article PeerReviewed Siddiqui, Ruqaiyyah and Ong, Timonthy Yu Yee * and Maciver, Sutherland and Khan, Naveed Ahmed (2023) Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route? Therapeutic Delivery, 14 (8). pp. 485-490. ISSN 2041-6008 https://doi.org/10.4155/tde-2023-0032 10.4155/tde-2023-0032
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
topic QL Zoology
RC Internal medicine
RM Therapeutics. Pharmacology
spellingShingle QL Zoology
RC Internal medicine
RM Therapeutics. Pharmacology
Siddiqui, Ruqaiyyah
Ong, Timonthy Yu Yee *
Maciver, Sutherland
Khan, Naveed Ahmed
Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
description Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.
format Article
author Siddiqui, Ruqaiyyah
Ong, Timonthy Yu Yee *
Maciver, Sutherland
Khan, Naveed Ahmed
author_facet Siddiqui, Ruqaiyyah
Ong, Timonthy Yu Yee *
Maciver, Sutherland
Khan, Naveed Ahmed
author_sort Siddiqui, Ruqaiyyah
title Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
title_short Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
title_full Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
title_fullStr Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
title_full_unstemmed Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?
title_sort can amphotericin b-mediated effects be limited using intranasal versus intravenous route?
publisher Wiley
publishDate 2023
url http://eprints.sunway.edu.my/2827/
https://doi.org/10.4155/tde-2023-0032
_version_ 1805893818757677056
score 13.211869

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