Staff View: Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has...

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Main Authors:	Nur Syafiqah, Rahim, Wu, Yuan Seng , Sim, Maw Shin, Vetriselvan, Subramaniyan, Choy, Ker Woon, Teow, Sin Yeang , Ismail, M. Fareez, Chandramathi, Samudi, Shamala, Devi Sekaran, Mahendran, Sekar, Guad, Rhanye Mac
Format:	Article
Language:	English
Published:	MDPI 2023
Subjects:	QH Natural history QP Physiology RC Internal medicine
Online Access:	http://eprints.sunway.edu.my/2787/1/Wu%20Yuan%20Seng_Three%20members%20of%20transmembrane-4-superfamily.pdf http://eprints.sunway.edu.my/2787/ https://doi.org/10.3390/ph16010110
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spelling	my.sunway.eprints.27872024-07-12T00:37:45Z http://eprints.sunway.edu.my/2787/ Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance Nur Syafiqah, Rahim Wu, Yuan Seng * Sim, Maw Shin Vetriselvan, Subramaniyan Choy, Ker Woon Teow, Sin Yeang * Ismail, M. Fareez Chandramathi, Samudi Shamala, Devi Sekaran Mahendran, Sekar Guad, Rhanye Mac QH Natural history QP Physiology RC Internal medicine There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has demonstrated, among six TM4SF members, the regulatory roles of transmembrane 4 L6 domain family members, particularly TM4SF1, TM4SF4, and TM4SF5, in cancer angiogenesis, progression, and chemoresistance. Hence, targeting derailed TM4SF for cancer therapy has become an emerging research area. As compared to others, this review aimed to present a focused insight and update on the biological roles of TM4SF1, TM4SF4, and TM4SF5 in the progression, metastasis, and chemoresistance of various cancers. Additionally, the mechanistic pathways, diagnostic and prognostic values, and the potential and efficacy of current anti-TM4SF antibody treatment were also deciphered. It also recommended the exploration of other interactive molecules to be implicated in cancer progression and chemoresistance, as well as potential therapeutic agents targeting TM4SF as future perspectives. Generally, these three TM4SF members interact with different integrins and receptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. Intriguingly, gene silencing or anti-TM4SF antibody could reverse their regulatory roles deciphered in different preclinical models. They also have prognostic and diagnostic value as their high expression was detected in clinical tissues and cells of various cancers. Hence, TM4SF1, TM4SF4, and TM4SF5 are promising therapeutic targets for different cancer types preclinically and deserve further investigation. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2787/1/Wu%20Yuan%20Seng_Three%20members%20of%20transmembrane-4-superfamily.pdf Nur Syafiqah, Rahim and Wu, Yuan Seng * and Sim, Maw Shin and Vetriselvan, Subramaniyan and Choy, Ker Woon and Teow, Sin Yeang * and Ismail, M. Fareez and Chandramathi, Samudi and Shamala, Devi Sekaran and Mahendran, Sekar and Guad, Rhanye Mac (2023) Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance. Pharmaceuticals, 16 (1). ISSN 1424-8247 https://doi.org/10.3390/ph16010110 10.3390/ph16010110
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
language	English
topic	QH Natural history QP Physiology RC Internal medicine
spellingShingle	QH Natural history QP Physiology RC Internal medicine Nur Syafiqah, Rahim Wu, Yuan Seng * Sim, Maw Shin Vetriselvan, Subramaniyan Choy, Ker Woon Teow, Sin Yeang * Ismail, M. Fareez Chandramathi, Samudi Shamala, Devi Sekaran Mahendran, Sekar Guad, Rhanye Mac Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
description	There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has demonstrated, among six TM4SF members, the regulatory roles of transmembrane 4 L6 domain family members, particularly TM4SF1, TM4SF4, and TM4SF5, in cancer angiogenesis, progression, and chemoresistance. Hence, targeting derailed TM4SF for cancer therapy has become an emerging research area. As compared to others, this review aimed to present a focused insight and update on the biological roles of TM4SF1, TM4SF4, and TM4SF5 in the progression, metastasis, and chemoresistance of various cancers. Additionally, the mechanistic pathways, diagnostic and prognostic values, and the potential and efficacy of current anti-TM4SF antibody treatment were also deciphered. It also recommended the exploration of other interactive molecules to be implicated in cancer progression and chemoresistance, as well as potential therapeutic agents targeting TM4SF as future perspectives. Generally, these three TM4SF members interact with different integrins and receptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. Intriguingly, gene silencing or anti-TM4SF antibody could reverse their regulatory roles deciphered in different preclinical models. They also have prognostic and diagnostic value as their high expression was detected in clinical tissues and cells of various cancers. Hence, TM4SF1, TM4SF4, and TM4SF5 are promising therapeutic targets for different cancer types preclinically and deserve further investigation.
format	Article
author	Nur Syafiqah, Rahim Wu, Yuan Seng * Sim, Maw Shin Vetriselvan, Subramaniyan Choy, Ker Woon Teow, Sin Yeang * Ismail, M. Fareez Chandramathi, Samudi Shamala, Devi Sekaran Mahendran, Sekar Guad, Rhanye Mac
author_facet	Nur Syafiqah, Rahim Wu, Yuan Seng * Sim, Maw Shin Vetriselvan, Subramaniyan Choy, Ker Woon Teow, Sin Yeang * Ismail, M. Fareez Chandramathi, Samudi Shamala, Devi Sekaran Mahendran, Sekar Guad, Rhanye Mac
author_sort	Nur Syafiqah, Rahim
title	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
title_short	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
title_full	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
title_fullStr	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
title_full_unstemmed	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
title_sort	three members of transmembrane-4-superfamily, tm4sf1, tm4sf4, and tm4sf5, as emerging anticancer molecular targets against cancer phenotypes and chemoresistance
publisher	MDPI
publishDate	2023
url	http://eprints.sunway.edu.my/2787/1/Wu%20Yuan%20Seng_Three%20members%20of%20transmembrane-4-superfamily.pdf http://eprints.sunway.edu.my/2787/ https://doi.org/10.3390/ph16010110
_version_	1805893812294254592
score	13.211869

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

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