Staff View: Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria

Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria

Background: Infectious diseases are the second leading cause of deaths worldwide. Pathogenic bacteria have been developing tremendous resistance against antibiotics which has placed an additional burden on healthcare systems. Gallic acid belongs to a naturally occurring phenolic class of compounds a...

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Main Authors:	Mohamed, Abdella, Lahiri, Chandrajit , Iskandar, Abdullah, Ayaz, Anwar
Format:	Article
Published:	Bentham Science Publishers 2024
Subjects:	QD Chemistry RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://eprints.sunway.edu.my/2781/ https://www.eurekaselect.com/article/133984
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spelling	my.sunway.eprints.27812024-07-15T00:42:24Z http://eprints.sunway.edu.my/2781/ Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria Mohamed, Abdella Lahiri, Chandrajit * Iskandar, Abdullah Ayaz, Anwar * QD Chemistry RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology Background: Infectious diseases are the second leading cause of deaths worldwide. Pathogenic bacteria have been developing tremendous resistance against antibiotics which has placed an additional burden on healthcare systems. Gallic acid belongs to a naturally occurring phenolic class of compounds and is known to possess a wide spectrum of antimicrobial activities. Aims & objectives: In this study, we synthesized thirteen derivatives of gallic acid and evaluated their antibacterial potential against seven multi-drug resistant bacteria, as well as cytotoxic effects against human embryonic kidney cell line in vitro. Methods: 13 compounds were successfully synthesized with moderate to good yield and evaluated. Synthesized derivatives were characterized by using nuclear magnetic resonance spectroscopy, mass spectrometry, and Fourier transformation infrared spectroscopy. Antibacterial activity was determined using microdilution while cytotoxicyt was assessed using MTT assay. Results: The results of antibacterial assay showed that seven out of thirteen compounds exhibited antibacterial effects with compound 6 and 13 being most potent against Staphylococcus aureus (MIC 56 μg/mL) and Salmonella enterica (MIC 475 μg/mL) respectively. On the other hand, most of these compounds showed lower cytotoxicity against human embryonic kidney cells (HEK 293), with IC50 values ranging from over 700 μg/mL. Conclusion: Notably, compound 13 was found to be non-toxic at concentrations as high as 5000 μg/mL. These findings suggest that the present synthetic derivatives of gallic acid hold potential for further studies in the development of potent antibacterial agents. Bentham Science Publishers 2024 Article PeerReviewed Mohamed, Abdella and Lahiri, Chandrajit * and Iskandar, Abdullah and Ayaz, Anwar * (2024) Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria. Medicinal Chemistry, 20 (2). pp. 130-139. ISSN 1875-6638 https://www.eurekaselect.com/article/133984 10.2174/1573406419666230823104300
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QD Chemistry RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	QD Chemistry RA Public aspects of medicine RC Internal medicine RM Therapeutics. Pharmacology Mohamed, Abdella Lahiri, Chandrajit * Iskandar, Abdullah Ayaz, Anwar * Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
description	Background: Infectious diseases are the second leading cause of deaths worldwide. Pathogenic bacteria have been developing tremendous resistance against antibiotics which has placed an additional burden on healthcare systems. Gallic acid belongs to a naturally occurring phenolic class of compounds and is known to possess a wide spectrum of antimicrobial activities. Aims & objectives: In this study, we synthesized thirteen derivatives of gallic acid and evaluated their antibacterial potential against seven multi-drug resistant bacteria, as well as cytotoxic effects against human embryonic kidney cell line in vitro. Methods: 13 compounds were successfully synthesized with moderate to good yield and evaluated. Synthesized derivatives were characterized by using nuclear magnetic resonance spectroscopy, mass spectrometry, and Fourier transformation infrared spectroscopy. Antibacterial activity was determined using microdilution while cytotoxicyt was assessed using MTT assay. Results: The results of antibacterial assay showed that seven out of thirteen compounds exhibited antibacterial effects with compound 6 and 13 being most potent against Staphylococcus aureus (MIC 56 μg/mL) and Salmonella enterica (MIC 475 μg/mL) respectively. On the other hand, most of these compounds showed lower cytotoxicity against human embryonic kidney cells (HEK 293), with IC50 values ranging from over 700 μg/mL. Conclusion: Notably, compound 13 was found to be non-toxic at concentrations as high as 5000 μg/mL. These findings suggest that the present synthetic derivatives of gallic acid hold potential for further studies in the development of potent antibacterial agents.
format	Article
author	Mohamed, Abdella Lahiri, Chandrajit * Iskandar, Abdullah Ayaz, Anwar *
author_facet	Mohamed, Abdella Lahiri, Chandrajit * Iskandar, Abdullah Ayaz, Anwar *
author_sort	Mohamed, Abdella
title	Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
title_short	Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
title_full	Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
title_fullStr	Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
title_full_unstemmed	Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria
title_sort	antibacterial evaluation of gallic acid and its derivatives against a panel of multi-drug resistant bacteria
publisher	Bentham Science Publishers
publishDate	2024
url	http://eprints.sunway.edu.my/2781/ https://www.eurekaselect.com/article/133984
_version_	1805893814754213888
score	13.211869

Antibacterial Evaluation of Gallic Acid and its Derivatives against a Panel of Multi-drug Resistant Bacteria

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