Staff View: Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to the...

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Main Authors:	Heng, Boon Chin *, Bai, Yunyang, Li, Xiaochan, Lim, Lee Wei, Li, Wang, Ge, Zigang, Zhang, Xuehui, Deng, Xuliang
Format:	Article
Published:	Wiley 2023
Subjects:	QM Human anatomy RA Public aspects of medicine RC Internal medicine
Online Access:	http://eprints.sunway.edu.my/2762/ https://doi.org/10.1002/advs.202204502
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id	my.sunway.eprints.2762
record_format	eprints
spelling	my.sunway.eprints.27622024-07-08T04:45:00Z http://eprints.sunway.edu.my/2762/ Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions Heng, Boon Chin * Bai, Yunyang Li, Xiaochan Lim, Lee Wei Li, Wang Ge, Zigang Zhang, Xuehui Deng, Xuliang QM Human anatomy RA Public aspects of medicine RC Internal medicine Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelectric properties. There is growing interest in utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy bone tissue to promote bone repair. This review first summarizes the etiology of degenerative bone conditions associated with various diseases such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, and metastatic osteolysis. Next, the diverse array of natural and synthetic electroactive biomaterials with therapeutic potential are discussed. Putative mechanistic pathways by which electroactive biomaterials can mitigate bone degeneration are critically examined, including the enhancement of osteogenesis and angiogenesis, suppression of inflammation and osteoclastogenesis, as well as their anti-bacterial effects. Finally, the limited research on utilization of electroactive biomaterials in the treatment of bone degeneration associated with the aforementioned diseases are examined. Previous studies have mostly focused on using electroactive biomaterials to treat bone traumatic injuries. It is hoped that this review will encourage more research efforts on the use of electroactive biomaterials for treating degenerative bone conditions. Wiley 2023 Article PeerReviewed Heng, Boon Chin * and Bai, Yunyang and Li, Xiaochan and Lim, Lee Wei and Li, Wang and Ge, Zigang and Zhang, Xuehui and Deng, Xuliang (2023) Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions. Advanced Science, 10 (2). ISSN 2198-3844 https://doi.org/10.1002/advs.202204502 10.1002/advs.202204502
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	QM Human anatomy RA Public aspects of medicine RC Internal medicine
spellingShingle	QM Human anatomy RA Public aspects of medicine RC Internal medicine Heng, Boon Chin * Bai, Yunyang Li, Xiaochan Lim, Lee Wei Li, Wang Ge, Zigang Zhang, Xuehui Deng, Xuliang Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
description	Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelectric properties. There is growing interest in utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy bone tissue to promote bone repair. This review first summarizes the etiology of degenerative bone conditions associated with various diseases such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, and metastatic osteolysis. Next, the diverse array of natural and synthetic electroactive biomaterials with therapeutic potential are discussed. Putative mechanistic pathways by which electroactive biomaterials can mitigate bone degeneration are critically examined, including the enhancement of osteogenesis and angiogenesis, suppression of inflammation and osteoclastogenesis, as well as their anti-bacterial effects. Finally, the limited research on utilization of electroactive biomaterials in the treatment of bone degeneration associated with the aforementioned diseases are examined. Previous studies have mostly focused on using electroactive biomaterials to treat bone traumatic injuries. It is hoped that this review will encourage more research efforts on the use of electroactive biomaterials for treating degenerative bone conditions.
format	Article
author	Heng, Boon Chin * Bai, Yunyang Li, Xiaochan Lim, Lee Wei Li, Wang Ge, Zigang Zhang, Xuehui Deng, Xuliang
author_facet	Heng, Boon Chin * Bai, Yunyang Li, Xiaochan Lim, Lee Wei Li, Wang Ge, Zigang Zhang, Xuehui Deng, Xuliang
author_sort	Heng, Boon Chin *
title	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
title_short	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
title_full	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
title_fullStr	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
title_full_unstemmed	Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions
title_sort	electroactive biomaterials for facilitating bone defect repair under pathological conditions
publisher	Wiley
publishDate	2023
url	http://eprints.sunway.edu.my/2762/ https://doi.org/10.1002/advs.202204502
_version_	1804069668777885696
score	13.211869

Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

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