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Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases

Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity and mortality caused by CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH oxidase (NOX)-derived re...

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Main Authors:	Siti Sarah, M Sofiullah, Dharmani, Devi Murugan, Suhaila, Abd Muid, Wu, Yuan Seng *, Sharifah Zamiah, Syed Abdul Kadir, Razif, Abas, Nurul Raudzah, Adib Ridzuan, Mor Hisam, Zamakshashari, Choy, Ker Woon
Format:	Article
Language:	English
Published:	MDPI 2023
Subjects:	QD Chemistry RB Pathology RC Internal medicine
Online Access:	http://eprints.sunway.edu.my/2747/1/Wu%20Yuan%20Seng_Natural%20bioactive%20compounds%20targeting%20NADPH%20oxidase%20pathway.pdf http://eprints.sunway.edu.my/2747/ https://doi.org/10.3390/molecules28031047
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spelling	my.sunway.eprints.27472024-07-08T01:32:23Z http://eprints.sunway.edu.my/2747/ Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases Siti Sarah, M Sofiullah Dharmani, Devi Murugan Suhaila, Abd Muid Wu, Yuan Seng * Sharifah Zamiah, Syed Abdul Kadir Razif, Abas Nurul Raudzah, Adib Ridzuan Mor Hisam, Zamakshashari Choy, Ker Woon QD Chemistry RB Pathology RC Internal medicine Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity and mortality caused by CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) production induces endothelial nitric oxide synthase (eNOS) uncoupling and mitochondrial dysfunction, resulting in sustained oxidative stress and the development of cardiovascular diseases. Seven distinct members of the family have been identified of which four (namely, NOX1, 2, 4 and 5) may have cardiovascular functions. Currently, the treatment and management plan for patients with CVDs mainly depends on the drugs. However, prolonged use of prescribed drugs may cause adverse drug reactions. Therefore, it is crucial to find alternative treatment options with lesser adverse effects. Natural products have been gaining interest as complementary therapy for CVDs over the past decade due to their wide range of medicinal properties, including antioxidants. These might be due to their potent active ingredients, such as flavonoid and phenolic compounds. Numerous natural compounds have been demonstrated to have advantageous effects on cardiovascular disease via NADPH cascade. This review highlights the potential of natural products targeting NOX-derived ROS generation in treating CVDs. Emphasis is put on the activation of the oxidases, including upstream or downstream signalling events. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2747/1/Wu%20Yuan%20Seng_Natural%20bioactive%20compounds%20targeting%20NADPH%20oxidase%20pathway.pdf Siti Sarah, M Sofiullah and Dharmani, Devi Murugan and Suhaila, Abd Muid and Wu, Yuan Seng * and Sharifah Zamiah, Syed Abdul Kadir and Razif, Abas and Nurul Raudzah, Adib Ridzuan and Mor Hisam, Zamakshashari and Choy, Ker Woon (2023) Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases. Molecules, 28 (3). ISSN 1420-3049 https://doi.org/10.3390/molecules28031047 10.3390/molecules28031047
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
language	English
topic	QD Chemistry RB Pathology RC Internal medicine
spellingShingle	QD Chemistry RB Pathology RC Internal medicine Siti Sarah, M Sofiullah Dharmani, Devi Murugan Suhaila, Abd Muid Wu, Yuan Seng * Sharifah Zamiah, Syed Abdul Kadir Razif, Abas Nurul Raudzah, Adib Ridzuan Mor Hisam, Zamakshashari Choy, Ker Woon Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
description	Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity and mortality caused by CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) production induces endothelial nitric oxide synthase (eNOS) uncoupling and mitochondrial dysfunction, resulting in sustained oxidative stress and the development of cardiovascular diseases. Seven distinct members of the family have been identified of which four (namely, NOX1, 2, 4 and 5) may have cardiovascular functions. Currently, the treatment and management plan for patients with CVDs mainly depends on the drugs. However, prolonged use of prescribed drugs may cause adverse drug reactions. Therefore, it is crucial to find alternative treatment options with lesser adverse effects. Natural products have been gaining interest as complementary therapy for CVDs over the past decade due to their wide range of medicinal properties, including antioxidants. These might be due to their potent active ingredients, such as flavonoid and phenolic compounds. Numerous natural compounds have been demonstrated to have advantageous effects on cardiovascular disease via NADPH cascade. This review highlights the potential of natural products targeting NOX-derived ROS generation in treating CVDs. Emphasis is put on the activation of the oxidases, including upstream or downstream signalling events.
format	Article
author	Siti Sarah, M Sofiullah Dharmani, Devi Murugan Suhaila, Abd Muid Wu, Yuan Seng * Sharifah Zamiah, Syed Abdul Kadir Razif, Abas Nurul Raudzah, Adib Ridzuan Mor Hisam, Zamakshashari Choy, Ker Woon
author_facet	Siti Sarah, M Sofiullah Dharmani, Devi Murugan Suhaila, Abd Muid Wu, Yuan Seng * Sharifah Zamiah, Syed Abdul Kadir Razif, Abas Nurul Raudzah, Adib Ridzuan Mor Hisam, Zamakshashari Choy, Ker Woon
author_sort	Siti Sarah, M Sofiullah
title	Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
title_short	Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
title_full	Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
title_fullStr	Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
title_full_unstemmed	Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
title_sort	natural bioactive compounds targeting nadph oxidase pathway in cardiovascular diseases
publisher	MDPI
publishDate	2023
url	http://eprints.sunway.edu.my/2747/1/Wu%20Yuan%20Seng_Natural%20bioactive%20compounds%20targeting%20NADPH%20oxidase%20pathway.pdf http://eprints.sunway.edu.my/2747/ https://doi.org/10.3390/molecules28031047
_version_	1804069666570633216
score	13.211869

Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases

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