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The Emerging Role of MMP12 in the Oral Environment

Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview...

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Main Authors: Lin, Bingpeng, Ser, Hooi Leng *, Wang, Lijing, Li, Jiang, Chan, Kok Gan, Lee, Learn-Han, Tan Loh, Teng Hern
Format: Article
Language:English
Published: MDPI 2023
Subjects:
QR Microbiology
RK Dentistry
Online Access:http://eprints.sunway.edu.my/2735/1/Ser%20Hooi%20Leng_Emerging%20role%20of%20MMP12.pdf
http://eprints.sunway.edu.my/2735/
https://doi.org/10.3390/ijms24054648
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spelling my.sunway.eprints.27352024-07-05T03:14:36Z http://eprints.sunway.edu.my/2735/ The Emerging Role of MMP12 in the Oral Environment Lin, Bingpeng Ser, Hooi Leng * Wang, Lijing Li, Jiang Chan, Kok Gan Lee, Learn-Han Tan Loh, Teng Hern QR Microbiology RK Dentistry Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2735/1/Ser%20Hooi%20Leng_Emerging%20role%20of%20MMP12.pdf Lin, Bingpeng and Ser, Hooi Leng * and Wang, Lijing and Li, Jiang and Chan, Kok Gan and Lee, Learn-Han and Tan Loh, Teng Hern (2023) The Emerging Role of MMP12 in the Oral Environment. International Journal of Molecular Sciences, 24 (5). ISSN 1422-0067 https://doi.org/10.3390/ijms24054648 10.3390/ijms24054648
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic QR Microbiology
RK Dentistry
spellingShingle QR Microbiology
RK Dentistry
Lin, Bingpeng
Ser, Hooi Leng *
Wang, Lijing
Li, Jiang
Chan, Kok Gan
Lee, Learn-Han
Tan Loh, Teng Hern
The Emerging Role of MMP12 in the Oral Environment
description Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.
format Article
author Lin, Bingpeng
Ser, Hooi Leng *
Wang, Lijing
Li, Jiang
Chan, Kok Gan
Lee, Learn-Han
Tan Loh, Teng Hern
author_facet Lin, Bingpeng
Ser, Hooi Leng *
Wang, Lijing
Li, Jiang
Chan, Kok Gan
Lee, Learn-Han
Tan Loh, Teng Hern
author_sort Lin, Bingpeng
title The Emerging Role of MMP12 in the Oral Environment
title_short The Emerging Role of MMP12 in the Oral Environment
title_full The Emerging Role of MMP12 in the Oral Environment
title_fullStr The Emerging Role of MMP12 in the Oral Environment
title_full_unstemmed The Emerging Role of MMP12 in the Oral Environment
title_sort emerging role of mmp12 in the oral environment
publisher MDPI
publishDate 2023
url http://eprints.sunway.edu.my/2735/1/Ser%20Hooi%20Leng_Emerging%20role%20of%20MMP12.pdf
http://eprints.sunway.edu.my/2735/
https://doi.org/10.3390/ijms24054648
_version_ 1804069664838385664
score 13.211869

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