Staff View: Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and t...

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Main Authors:	Morshed, A K M Helal, Paul, Supti, Hossain, Arafat, Basak, Tuli, Hossain, Md Sanower, Hasan, Md Mehedi, Hasibuzzaman, Md Al, Tanjim, Ishraq Rahaman, Md Abdur, Rashid Mia, Shing, Pollob, Sohel, Md, Bibi, Shabana, Dey, Dipta, Biswas, Partha, Hasan, Md Nazmul, Long, Chiau Ming *, Tan, Ching Siang
Format:	Article
Language:	English
Published:	MDPI 2023
Subjects:	QH Natural history QP Physiology R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://eprints.sunway.edu.my/2730/1/Long%20Chiau%20Ming_Baicalein%20as%20promising%20anticancer%20agent.pdf http://eprints.sunway.edu.my/2730/ https://doi.org/10.3390/cancers15072128
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spelling	my.sunway.eprints.27302024-07-04T01:05:47Z http://eprints.sunway.edu.my/2730/ Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md Sanower Hasan, Md Mehedi Hasibuzzaman, Md Al Tanjim, Ishraq Rahaman Md Abdur, Rashid Mia Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md Nazmul Long, Chiau Ming * Tan, Ching Siang QH Natural history QP Physiology R Medicine (General) RM Therapeutics. Pharmacology Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein's anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2730/1/Long%20Chiau%20Ming_Baicalein%20as%20promising%20anticancer%20agent.pdf Morshed, A K M Helal and Paul, Supti and Hossain, Arafat and Basak, Tuli and Hossain, Md Sanower and Hasan, Md Mehedi and Hasibuzzaman, Md Al and Tanjim, Ishraq Rahaman and Md Abdur, Rashid Mia and Shing, Pollob and Sohel, Md and Bibi, Shabana and Dey, Dipta and Biswas, Partha and Hasan, Md Nazmul and Long, Chiau Ming * and Tan, Ching Siang (2023) Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives. Cancers, 15 (7). ISSN 2072-6694 https://doi.org/10.3390/cancers15072128 10.3390/cancers15072128
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
language	English
topic	QH Natural history QP Physiology R Medicine (General) RM Therapeutics. Pharmacology
spellingShingle	QH Natural history QP Physiology R Medicine (General) RM Therapeutics. Pharmacology Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md Sanower Hasan, Md Mehedi Hasibuzzaman, Md Al Tanjim, Ishraq Rahaman Md Abdur, Rashid Mia Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md Nazmul Long, Chiau Ming * Tan, Ching Siang Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
description	Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein's anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study.
format	Article
author	Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md Sanower Hasan, Md Mehedi Hasibuzzaman, Md Al Tanjim, Ishraq Rahaman Md Abdur, Rashid Mia Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md Nazmul Long, Chiau Ming * Tan, Ching Siang
author_facet	Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md Sanower Hasan, Md Mehedi Hasibuzzaman, Md Al Tanjim, Ishraq Rahaman Md Abdur, Rashid Mia Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md Nazmul Long, Chiau Ming * Tan, Ching Siang
author_sort	Morshed, A K M Helal
title	Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
title_short	Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
title_full	Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
title_fullStr	Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
title_full_unstemmed	Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
title_sort	baicalein as promising anticancer agent: a comprehensive analysis on molecular mechanisms and therapeutic perspectives
publisher	MDPI
publishDate	2023
url	http://eprints.sunway.edu.my/2730/1/Long%20Chiau%20Ming_Baicalein%20as%20promising%20anticancer%20agent.pdf http://eprints.sunway.edu.my/2730/ https://doi.org/10.3390/cancers15072128
_version_	1804069664105431040
score	13.222552

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

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