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Development of oncolytic viruses for cancer therapy

Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic viroth...

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Main Authors: Noraini Abd Aziz, *, Poh, Chit Laa *
Format: Article
Published: Elsevier 2021
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://eprints.sunway.edu.my/1778/
http://doi.org/10.1016/j.trsl.2021.04.008
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spelling my.sunway.eprints.17782021-07-14T05:34:16Z http://eprints.sunway.edu.my/1778/ Development of oncolytic viruses for cancer therapy Noraini Abd Aziz, * Poh, Chit Laa * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies. Elsevier 2021 Article PeerReviewed Noraini Abd Aziz, * and Poh, Chit Laa * (2021) Development of oncolytic viruses for cancer therapy. Translational Research: The Journal of Laboratory and Clinical Medicine. ISSN 1931-5244 (In Press) http://doi.org/10.1016/j.trsl.2021.04.008 doi:10.1016/j.trsl.2021.04.008
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Noraini Abd Aziz, *
Poh, Chit Laa *
Development of oncolytic viruses for cancer therapy
description Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies.
format Article
author Noraini Abd Aziz, *
Poh, Chit Laa *
author_facet Noraini Abd Aziz, *
Poh, Chit Laa *
author_sort Noraini Abd Aziz, *
title Development of oncolytic viruses for cancer therapy
title_short Development of oncolytic viruses for cancer therapy
title_full Development of oncolytic viruses for cancer therapy
title_fullStr Development of oncolytic viruses for cancer therapy
title_full_unstemmed Development of oncolytic viruses for cancer therapy
title_sort development of oncolytic viruses for cancer therapy
publisher Elsevier
publishDate 2021
url http://eprints.sunway.edu.my/1778/
http://doi.org/10.1016/j.trsl.2021.04.008
_version_ 1706960066198896640
score 13.211869

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