Staff View: Feasibility study of a minibeam collimator design for a 60Co gamma irradiator

Feasibility study of a minibeam collimator design for a 60Co gamma irradiator

Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiot...

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Main Authors:	Moradi, F., Khandaker, Mayeen Uddin , Abdul Sani, S.F., Uguru, E.H., Sulieman, A., Bradley, D.A.
Format:	Article
Published:	Elsevier 2021
Subjects:	R895-920 Medical Physics/Medical Radiology
Online Access:	http://eprints.sunway.edu.my/1570/ http://doi.org/10.1016/j.radphyschem.2020.109026
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spelling	my.sunway.eprints.15702021-11-18T01:53:33Z http://eprints.sunway.edu.my/1570/ Feasibility study of a minibeam collimator design for a 60Co gamma irradiator Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * R895-920 Medical Physics/Medical Radiology Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiotherapy (MRT), albeit limited in access and typically offering photon energies very much lower than familiar in the practice of conventional radiotherapy. In this study of feasibility, the design has been investigated of a collimator coupled to a conventional 60Co gamma-irradiator sample chamber to produce a minibeam. MCNPX code Monte Carlo simulations were used to model a Gammacell 220 60Co irradiator with lead and tungsten collimators. The dose profile was evaluated in the absence and presence of the collimator, seeking to optimize collimator design. The results pertain to specific shapes of lead and tungsten collimators producing narrow (millimeter dimension) beams, sufficient in thickness but yet still fitting within the sample chamber, with a peak-to-valley dose ratio (PVDR) greater than 15. The beam size can be tailored with modification in the size of the perforated part, the collimator optimized to minimize the dose-rate at points away from the collimator centre. However the dose-rate at the centre is reduced to between 2 to 20% of that in the absence of collimator. The findings of this study encourage the development of minibeam collimator for gamma irradiators, useful for preclinical minibeam radiotherapy research in centres with little or no access to other appropriate sources. Elsevier 2021-06-11 Article PeerReviewed Moradi, F. and Khandaker, Mayeen Uddin * and Abdul Sani, S.F. and Uguru, E.H. and Sulieman, A. and Bradley, D.A. * (2021) Feasibility study of a minibeam collimator design for a 60Co gamma irradiator. Radiation Physics and Chemistry, 178. p. 109026. ISSN 0969806X http://doi.org/10.1016/j.radphyschem.2020.109026 doi:10.1016/j.radphyschem.2020.109026
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	R895-920 Medical Physics/Medical Radiology
spellingShingle	R895-920 Medical Physics/Medical Radiology Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
description	Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiotherapy (MRT), albeit limited in access and typically offering photon energies very much lower than familiar in the practice of conventional radiotherapy. In this study of feasibility, the design has been investigated of a collimator coupled to a conventional 60Co gamma-irradiator sample chamber to produce a minibeam. MCNPX code Monte Carlo simulations were used to model a Gammacell 220 60Co irradiator with lead and tungsten collimators. The dose profile was evaluated in the absence and presence of the collimator, seeking to optimize collimator design. The results pertain to specific shapes of lead and tungsten collimators producing narrow (millimeter dimension) beams, sufficient in thickness but yet still fitting within the sample chamber, with a peak-to-valley dose ratio (PVDR) greater than 15. The beam size can be tailored with modification in the size of the perforated part, the collimator optimized to minimize the dose-rate at points away from the collimator centre. However the dose-rate at the centre is reduced to between 2 to 20% of that in the absence of collimator. The findings of this study encourage the development of minibeam collimator for gamma irradiators, useful for preclinical minibeam radiotherapy research in centres with little or no access to other appropriate sources.
format	Article
author	Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. *
author_facet	Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. *
author_sort	Moradi, F.
title	Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
title_short	Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
title_full	Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
title_fullStr	Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
title_full_unstemmed	Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
title_sort	feasibility study of a minibeam collimator design for a 60co gamma irradiator
publisher	Elsevier
publishDate	2021
url	http://eprints.sunway.edu.my/1570/ http://doi.org/10.1016/j.radphyschem.2020.109026
_version_	1718929288792637440
score	13.211869

Feasibility study of a minibeam collimator design for a 60Co gamma irradiator

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