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Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.

The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis...

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Main Authors: Loo, Kong Yong, Leong, Kok Hoong, Yasodha Sivasothy, *, Halijah Ibrahim,, Khalijah Awang,
Format: Article
Language:English
Published: Wiley 2019
Subjects:
QD Chemistry
Online Access:http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf
http://eprints.sunway.edu.my/1121/
http://doi.org/10.1002/cbdv.201900032
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spelling my.sunway.eprints.11212019-11-15T01:45:48Z http://eprints.sunway.edu.my/1121/ Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. Loo, Kong Yong Leong, Kok Hoong Yasodha Sivasothy, * Halijah Ibrahim, Khalijah Awang, QD Chemistry The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes. Wiley 2019-06 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf Loo, Kong Yong and Leong, Kok Hoong and Yasodha Sivasothy, * and Halijah Ibrahim, and Khalijah Awang, (2019) Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. Chemistry & Biodiversity, 16 (6). e1900032. ISSN 1612-1872 http://doi.org/10.1002/cbdv.201900032 doi:10.1002/cbdv.201900032
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Loo, Kong Yong
Leong, Kok Hoong
Yasodha Sivasothy, *
Halijah Ibrahim,
Khalijah Awang,
Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
description The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes.
format Article
author Loo, Kong Yong
Leong, Kok Hoong
Yasodha Sivasothy, *
Halijah Ibrahim,
Khalijah Awang,
author_facet Loo, Kong Yong
Leong, Kok Hoong
Yasodha Sivasothy, *
Halijah Ibrahim,
Khalijah Awang,
author_sort Loo, Kong Yong
title Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
title_short Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
title_full Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
title_fullStr Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
title_full_unstemmed Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
title_sort molecular insight and mode of inhibition of α ‐glucosidase and α ‐amylase by pahangensin a from alpinia pahangensis ridl.
publisher Wiley
publishDate 2019
url http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf
http://eprints.sunway.edu.my/1121/
http://doi.org/10.1002/cbdv.201900032
_version_ 1651870924539953152
score 13.211869

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