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Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a nee...

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Main Authors: Mohd Ishtiaq Anasir, *, Poh, Chit Laa *
Format: Article
Language:English
Published: MDPI 2019
Subjects:
QR355 Virology
Online Access:http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf
http://eprints.sunway.edu.my/1094/
http://doi.org/10.3390/ijms20061256
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spelling my.sunway.eprints.10942019-09-19T01:59:24Z http://eprints.sunway.edu.my/1094/ Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease Mohd Ishtiaq Anasir, * Poh, Chit Laa * QR355 Virology Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents. MDPI 2019-03-13 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf Mohd Ishtiaq Anasir, * and Poh, Chit Laa * (2019) Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease. International Journal of Molecular Sciences, 20 (6). p. 1256. ISSN 1422-0067 http://doi.org/10.3390/ijms20061256 doi:10.3390/ijms20061256
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic QR355 Virology
spellingShingle QR355 Virology
Mohd Ishtiaq Anasir, *
Poh, Chit Laa *
Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
description Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents.
format Article
author Mohd Ishtiaq Anasir, *
Poh, Chit Laa *
author_facet Mohd Ishtiaq Anasir, *
Poh, Chit Laa *
author_sort Mohd Ishtiaq Anasir, *
title Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
title_short Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
title_full Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
title_fullStr Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
title_full_unstemmed Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
title_sort advances in antigenic peptide-based vaccine and neutralizing antibodies against viruses causing hand, foot, and mouth disease
publisher MDPI
publishDate 2019
url http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf
http://eprints.sunway.edu.my/1094/
http://doi.org/10.3390/ijms20061256
_version_ 1646104514649915392
score 13.211869

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