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Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity

Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classi...

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Main Authors: Salam, Moushumi Tabassoom, Kumar, Ashim, Salam, Md. Abdus, Ibne Wahed, Mir Imam, Barman, Ranjan Kumar
Format: Article
Language:English
Published: Association of Pharmaceutical Teachers of India 2022
Subjects:
RM Therapeutics. Pharmacology
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/99924/2/99924_Cefuroxime%20Axetil%20loaded%20dispersed%20formulation.pdf
http://irep.iium.edu.my/99924/
http://doi.org/10.5530/ijper.56.3s.153
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spelling my.iium.irep.999242022-09-12T00:32:53Z http://irep.iium.edu.my/99924/ Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity Salam, Moushumi Tabassoom Kumar, Ashim Salam, Md. Abdus Ibne Wahed, Mir Imam Barman, Ranjan Kumar RM Therapeutics. Pharmacology RM300 Drugs and their action Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classification System (BCS) with poor aqueous solubility and high absorption permeability after oral administration. The objective of this current work was to achieve the enhanced solubility in water and subsequent antibacterial activity of CA loaded coarse dispersion (CCD) formulations. Materials and Methods: CCDs were prepared by anti-solvent precipitation method by blending CA with a carrier, Microcrystalline cellulose (MCC) at different ratios. In-vitro dissolution test using paddle method and antibacterial study against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) were carried out for both pure CA and CCDs for performance comparison. Results: Among the formulations, CCD-3 exhibited maximized dissolution rate by 1.67-fold higher than that of pure CA with the drug-carrier (CA: MCC) ratio of 1:3. Antibacterial activity of CCD-3 against S. aureus and E. coli was also found by 1.75-fold and 5.25-fold higher relative zone of inhibition (RZOI), respectively than that of pure drug. Conclusion: As an optimized formulation, CCD-3 is a promising to be a fruitful substitute to conventional dosage forms of CA for the modified dissolution rate and antibacterial potency. However, before its recommendation as a novel formulation validation study to point its pharmacokinetics, competence with in-vivo antibacterial property and safety is needed. Association of Pharmaceutical Teachers of India 2022 Article PeerReviewed application/pdf en http://irep.iium.edu.my/99924/2/99924_Cefuroxime%20Axetil%20loaded%20dispersed%20formulation.pdf Salam, Moushumi Tabassoom and Kumar, Ashim and Salam, Md. Abdus and Ibne Wahed, Mir Imam and Barman, Ranjan Kumar (2022) Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity. Indian Journal of Pharmaceutical Education and Research, 56 (3). s454-s461. ISSN 0019-5464 http://doi.org/10.5530/ijper.56.3s.153 doi:10.5530/ijper.56.3s.153
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RM Therapeutics. Pharmacology
RM300 Drugs and their action
spellingShingle RM Therapeutics. Pharmacology
RM300 Drugs and their action
Salam, Moushumi Tabassoom
Kumar, Ashim
Salam, Md. Abdus
Ibne Wahed, Mir Imam
Barman, Ranjan Kumar
Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
description Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classification System (BCS) with poor aqueous solubility and high absorption permeability after oral administration. The objective of this current work was to achieve the enhanced solubility in water and subsequent antibacterial activity of CA loaded coarse dispersion (CCD) formulations. Materials and Methods: CCDs were prepared by anti-solvent precipitation method by blending CA with a carrier, Microcrystalline cellulose (MCC) at different ratios. In-vitro dissolution test using paddle method and antibacterial study against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) were carried out for both pure CA and CCDs for performance comparison. Results: Among the formulations, CCD-3 exhibited maximized dissolution rate by 1.67-fold higher than that of pure CA with the drug-carrier (CA: MCC) ratio of 1:3. Antibacterial activity of CCD-3 against S. aureus and E. coli was also found by 1.75-fold and 5.25-fold higher relative zone of inhibition (RZOI), respectively than that of pure drug. Conclusion: As an optimized formulation, CCD-3 is a promising to be a fruitful substitute to conventional dosage forms of CA for the modified dissolution rate and antibacterial potency. However, before its recommendation as a novel formulation validation study to point its pharmacokinetics, competence with in-vivo antibacterial property and safety is needed.
format Article
author Salam, Moushumi Tabassoom
Kumar, Ashim
Salam, Md. Abdus
Ibne Wahed, Mir Imam
Barman, Ranjan Kumar
author_facet Salam, Moushumi Tabassoom
Kumar, Ashim
Salam, Md. Abdus
Ibne Wahed, Mir Imam
Barman, Ranjan Kumar
author_sort Salam, Moushumi Tabassoom
title Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
title_short Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
title_full Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
title_fullStr Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
title_full_unstemmed Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
title_sort cefuroxime axetil loaded dispersed formulation for enhanced drug release and antibacterial activity
publisher Association of Pharmaceutical Teachers of India
publishDate 2022
url http://irep.iium.edu.my/99924/2/99924_Cefuroxime%20Axetil%20loaded%20dispersed%20formulation.pdf
http://irep.iium.edu.my/99924/
http://doi.org/10.5530/ijper.56.3s.153
_version_ 1744353533742809088
score 13.211869

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