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Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur

Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye(DE) patients. This study evaluated the MGDo and its association with lid margin...

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Main Authors: Hajar Maidin, Mohamad Hanif, Mohd Ali, Bariah, Mohammed, Zainora, Mohamed, Jamaludin
Format: Article
Language:English
Published: Penerbit UKM 2020
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RE Ophthalmology
Online Access:http://irep.iium.edu.my/99745/1/99745_Meibomian%20gland%20dropout.pdf
http://irep.iium.edu.my/99745/
http://www.ukm.my/jsm/pdf_files/SM-PDF-49-4-2020/9.pdf
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spelling my.iium.irep.997452022-08-31T00:29:45Z http://irep.iium.edu.my/99745/ Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur Hajar Maidin, Mohamad Hanif Mohd Ali, Bariah Mohammed, Zainora Mohamed, Jamaludin RE Ophthalmology Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye(DE) patients. This study evaluated the MGDo and its association with lid margin inflammation in young adults using meibography and lid wiper epitheliopathy (LWE) techniques. Other ocular surface appearance (cornea, conjunctiva and limbus) were also examined. A total of 107 healthy noncontact lens wearers were evaluated (mean age: 23.06 ± 2.63years old). All subjects were screened with McMonnies Dry Eye Questionnaire (MDEQ) before undergoing clinical investigations using slit-lamp biomicroscope, LWE and meibography. Cornea, conjunctiva and limbus appearances weregraded using the Efron grading scale. Following the MDEQ score, 36 subjects were classified as DE (mean 16.49± 1.74), and 71 subjects were classified as non-DE (NDE, mean score: 7.23 ± 3.09). The difference in corneal staining between both groups was significant (χ2 [1, N = 107] = 18.01, p < 0.05). A total of 70% of subjects had LWE staining which was more apparent in subjects with DE (χ2 [1, N = 107] = 13.17, p < 0.01). The meiboscore indicated that44.85% of subjects had MGDo, with a higher percentage (72.22%) in DE. There were significant differences between meiboscore in both groups (χ2 [1, N = 107] = 16.42, p < 0.05). However, there was weak and insignificant correlation between LWE and meiboscore (rs = 0.14, p = 0.16). Positive correlations were noted between MDEQ and LWE (rs =0.49, p < 0.01), MDEQ and corneal staining (r s = 0.36, p < 0.01) and MDEQ and meiboscore (rs = 0.24, p < 0.05).The results of this study demonstrated the differences in MGDo, LWE and ocular surface appearances between DE and NDE of the young adults but MGDo was not associated with LWE. Larger number of subjects is needed to confirm these findings. Penerbit UKM 2020-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/99745/1/99745_Meibomian%20gland%20dropout.pdf Hajar Maidin, Mohamad Hanif and Mohd Ali, Bariah and Mohammed, Zainora and Mohamed, Jamaludin (2020) Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur. Sains Malaysiana, 49 (4). pp. 801-808. ISSN 0126-6039 E-ISSN 2735-0118 http://www.ukm.my/jsm/pdf_files/SM-PDF-49-4-2020/9.pdf 10.17576/jsm-2020-4904-09
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RE Ophthalmology
spellingShingle RE Ophthalmology
Hajar Maidin, Mohamad Hanif
Mohd Ali, Bariah
Mohammed, Zainora
Mohamed, Jamaludin
Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
description Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye(DE) patients. This study evaluated the MGDo and its association with lid margin inflammation in young adults using meibography and lid wiper epitheliopathy (LWE) techniques. Other ocular surface appearance (cornea, conjunctiva and limbus) were also examined. A total of 107 healthy noncontact lens wearers were evaluated (mean age: 23.06 ± 2.63years old). All subjects were screened with McMonnies Dry Eye Questionnaire (MDEQ) before undergoing clinical investigations using slit-lamp biomicroscope, LWE and meibography. Cornea, conjunctiva and limbus appearances weregraded using the Efron grading scale. Following the MDEQ score, 36 subjects were classified as DE (mean 16.49± 1.74), and 71 subjects were classified as non-DE (NDE, mean score: 7.23 ± 3.09). The difference in corneal staining between both groups was significant (χ2 [1, N = 107] = 18.01, p < 0.05). A total of 70% of subjects had LWE staining which was more apparent in subjects with DE (χ2 [1, N = 107] = 13.17, p < 0.01). The meiboscore indicated that44.85% of subjects had MGDo, with a higher percentage (72.22%) in DE. There were significant differences between meiboscore in both groups (χ2 [1, N = 107] = 16.42, p < 0.05). However, there was weak and insignificant correlation between LWE and meiboscore (rs = 0.14, p = 0.16). Positive correlations were noted between MDEQ and LWE (rs =0.49, p < 0.01), MDEQ and corneal staining (r s = 0.36, p < 0.01) and MDEQ and meiboscore (rs = 0.24, p < 0.05).The results of this study demonstrated the differences in MGDo, LWE and ocular surface appearances between DE and NDE of the young adults but MGDo was not associated with LWE. Larger number of subjects is needed to confirm these findings.
format Article
author Hajar Maidin, Mohamad Hanif
Mohd Ali, Bariah
Mohammed, Zainora
Mohamed, Jamaludin
author_facet Hajar Maidin, Mohamad Hanif
Mohd Ali, Bariah
Mohammed, Zainora
Mohamed, Jamaludin
author_sort Hajar Maidin, Mohamad Hanif
title Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_short Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_full Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_fullStr Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_full_unstemmed Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_sort meibomian gland dropout and ocular surface appearances of young adults in kuala lumpur
publisher Penerbit UKM
publishDate 2020
url http://irep.iium.edu.my/99745/1/99745_Meibomian%20gland%20dropout.pdf
http://irep.iium.edu.my/99745/
http://www.ukm.my/jsm/pdf_files/SM-PDF-49-4-2020/9.pdf
_version_ 1743106849079558144
score 13.211869

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