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Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units

Background: Early detection of bacterial coinfection in severe dengue remains challenging. Point-of-care (POC) procalcitonin (PCT) may be used for this role, but it needs to be investigated. We evaluated the performance of POC PCT for early detection of bacterial coinfection in patients with sever...

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Main Authors: Wan Azmi, Wan Aida, Wan Muhd Shukeri, Wan Fadzlina, Mat Nor, Mohd Basri, Ramly, Nur fariza, Seevaunnatum, Praveena
Format: Article
Language:English
Published: Apicare Publications 2022
Subjects:
RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Online Access:http://irep.iium.edu.my/99688/1/99688_Point-of-care%20procalcitonin.pdf
http://irep.iium.edu.my/99688/
https://www.apicareonline.com/index.php/APIC/article/view/1960/2849
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spelling my.iium.irep.996882022-08-29T00:37:48Z http://irep.iium.edu.my/99688/ Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units Wan Azmi, Wan Aida Wan Muhd Shukeri, Wan Fadzlina Mat Nor, Mohd Basri Ramly, Nur fariza Seevaunnatum, Praveena RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid Background: Early detection of bacterial coinfection in severe dengue remains challenging. Point-of-care (POC) procalcitonin (PCT) may be used for this role, but it needs to be investigated. We evaluated the performance of POC PCT for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units (ICU). Methodology: In this cross-sectional study, we analyzed PCT level in severe dengue patients with and without bacterial coinfection upon their ICU admission. The diagnostic efficacy of PCT for the coinfection was determined through analysis of the receiver operating characteristics (ROC) curve. Results: Fifty patients with severe dengue were enrolled over a one-year period. Fourteen (28.0%) of these patients had bacterial coinfection on ICU admission. PCT was significantly higher in patients with the coinfection than those without (36.2 ± 41.8 vs 3.6 ± 5.6 ng/mL, P = 0.012). The Area Under the Curve (AUC) of 0.768, ideal cut-off of more than 4.6 ng/mL, sensitivity of 64.3% and specificity of 83.3% revealed that PCT was a good marker for detecting bacterial coinfection in our severe dengue cohort. Conclusion: Point-of-care procalcitonin provides early detection of bacterial coinfection with a good performance in patients with severe dengue; however, larger studies are warranted to validate these findings with quantification. Abbreviations: APACHE - Acute Physiological and Chronic Health Evaluation; AUC - Area Under the Curve; CRP - Creactive protein; ICU - intensive care unit; POC - Point-of-care; PCT – procalcitonin; ROC - receiver operating characteristics curve Apicare Publications 2022-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/99688/1/99688_Point-of-care%20procalcitonin.pdf Wan Azmi, Wan Aida and Wan Muhd Shukeri, Wan Fadzlina and Mat Nor, Mohd Basri and Ramly, Nur fariza and Seevaunnatum, Praveena (2022) Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units. Anaesthesia, Pain and Intensive Care, 26 (4). pp. 523-529. ISSN 1607-8322 E-ISSN 2220-5799 https://www.apicareonline.com/index.php/APIC/article/view/1960/2849 10.35975/apic.v26i4.1960
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
spellingShingle RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Wan Azmi, Wan Aida
Wan Muhd Shukeri, Wan Fadzlina
Mat Nor, Mohd Basri
Ramly, Nur fariza
Seevaunnatum, Praveena
Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
description Background: Early detection of bacterial coinfection in severe dengue remains challenging. Point-of-care (POC) procalcitonin (PCT) may be used for this role, but it needs to be investigated. We evaluated the performance of POC PCT for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units (ICU). Methodology: In this cross-sectional study, we analyzed PCT level in severe dengue patients with and without bacterial coinfection upon their ICU admission. The diagnostic efficacy of PCT for the coinfection was determined through analysis of the receiver operating characteristics (ROC) curve. Results: Fifty patients with severe dengue were enrolled over a one-year period. Fourteen (28.0%) of these patients had bacterial coinfection on ICU admission. PCT was significantly higher in patients with the coinfection than those without (36.2 ± 41.8 vs 3.6 ± 5.6 ng/mL, P = 0.012). The Area Under the Curve (AUC) of 0.768, ideal cut-off of more than 4.6 ng/mL, sensitivity of 64.3% and specificity of 83.3% revealed that PCT was a good marker for detecting bacterial coinfection in our severe dengue cohort. Conclusion: Point-of-care procalcitonin provides early detection of bacterial coinfection with a good performance in patients with severe dengue; however, larger studies are warranted to validate these findings with quantification. Abbreviations: APACHE - Acute Physiological and Chronic Health Evaluation; AUC - Area Under the Curve; CRP - Creactive protein; ICU - intensive care unit; POC - Point-of-care; PCT – procalcitonin; ROC - receiver operating characteristics curve
format Article
author Wan Azmi, Wan Aida
Wan Muhd Shukeri, Wan Fadzlina
Mat Nor, Mohd Basri
Ramly, Nur fariza
Seevaunnatum, Praveena
author_facet Wan Azmi, Wan Aida
Wan Muhd Shukeri, Wan Fadzlina
Mat Nor, Mohd Basri
Ramly, Nur fariza
Seevaunnatum, Praveena
author_sort Wan Azmi, Wan Aida
title Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
title_short Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
title_full Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
title_fullStr Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
title_full_unstemmed Point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
title_sort point-of-care procalcitonin for early detection of bacterial coinfection in patients with severe dengue admitted to the intensive care units
publisher Apicare Publications
publishDate 2022
url http://irep.iium.edu.my/99688/1/99688_Point-of-care%20procalcitonin.pdf
http://irep.iium.edu.my/99688/
https://www.apicareonline.com/index.php/APIC/article/view/1960/2849
_version_ 1743106846791565312
score 13.211869

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