Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia
Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was com...
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John Wiley and Sons Inc
2022
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| Online Access: | http://irep.iium.edu.my/98902/7/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI.pdf http://irep.iium.edu.my/98902/8/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI_Scopus.pdf http://irep.iium.edu.my/98902/ https://onlinelibrary.wiley.com/doi/10.1002/jnr.25023 |
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my.iium.irep.989022022-07-25T03:21:36Z http://irep.iium.edu.my/98902/ Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia Wen, Jia Chai Abdul Hamid, Aini Ismafairus Omar, Hazim Abdul Rahman, Muhammad Riddha Fitzrol, Diana Noma Idris, Zamzuri Ghani, Abdul Rahman Izaini Wan Mohamad, Wan Nor Azlen Mustafar, Faiz Hanafi, Muhammad Hafiz Kandasamy, Regunath Abdullah, Mohd Zaid Amaruchkul, Kannapha Valdes-Sosa, Pedro Bringas-Vega, Maria Biswal, Bharat Songsiri, Jitkomut Yaacob, Hamwira Sakti Ibrahim, Haidi Sumari, Putra Noh, Nor Azila Musa, Kamarul Imran Ahmad, Asma Hayati Azman, Azlinda Jamir Singh, Paramjit Singh Othman, Azizah Abdullah, Jafri Malin RC Internal medicine Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild-moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy: n = 26 and TBI: n = 15) performed two variations of the n-back WM task with four load conditions (0-, 1-, 2-, and 3-back). The respective within-group effects showed a right hemisphere-dominance activation and slower reaction in performance for the TBI group. Random-effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n-back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n-back without cues. The left middle frontal gyrus was implicated in the load-dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild-moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non-Western sample. John Wiley and Sons Inc 2022-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/98902/7/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI.pdf application/pdf en http://irep.iium.edu.my/98902/8/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI_Scopus.pdf Wen, Jia Chai and Abdul Hamid, Aini Ismafairus and Omar, Hazim and Abdul Rahman, Muhammad Riddha and Fitzrol, Diana Noma and Idris, Zamzuri and Ghani, Abdul Rahman Izaini and Wan Mohamad, Wan Nor Azlen and Mustafar, Faiz and Hanafi, Muhammad Hafiz and Kandasamy, Regunath and Abdullah, Mohd Zaid and Amaruchkul, Kannapha and Valdes-Sosa, Pedro and Bringas-Vega, Maria and Biswal, Bharat and Songsiri, Jitkomut and Yaacob, Hamwira Sakti and Ibrahim, Haidi and Sumari, Putra and Noh, Nor Azila and Musa, Kamarul Imran and Ahmad, Asma Hayati and Azman, Azlinda and Jamir Singh, Paramjit Singh and Othman, Azizah and Abdullah, Jafri Malin (2022) Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia. Journal of Neuroscience Research, 100 (4). pp. 915-932. ISSN 0360-4012 E-ISSN 1097-4547 https://onlinelibrary.wiley.com/doi/10.1002/jnr.25023 10.1002/jnr.25023 |
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RC Internal medicine |
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RC Internal medicine Wen, Jia Chai Abdul Hamid, Aini Ismafairus Omar, Hazim Abdul Rahman, Muhammad Riddha Fitzrol, Diana Noma Idris, Zamzuri Ghani, Abdul Rahman Izaini Wan Mohamad, Wan Nor Azlen Mustafar, Faiz Hanafi, Muhammad Hafiz Kandasamy, Regunath Abdullah, Mohd Zaid Amaruchkul, Kannapha Valdes-Sosa, Pedro Bringas-Vega, Maria Biswal, Bharat Songsiri, Jitkomut Yaacob, Hamwira Sakti Ibrahim, Haidi Sumari, Putra Noh, Nor Azila Musa, Kamarul Imran Ahmad, Asma Hayati Azman, Azlinda Jamir Singh, Paramjit Singh Othman, Azizah Abdullah, Jafri Malin Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| description |
Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild-moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy: n = 26 and TBI: n = 15) performed two variations of the n-back WM task with four load conditions (0-, 1-, 2-, and 3-back). The respective within-group effects showed a right hemisphere-dominance activation and slower reaction in performance for the TBI group. Random-effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n-back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n-back without cues. The left middle frontal gyrus was implicated in the load-dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild-moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non-Western sample. |
| format |
Article |
| author |
Wen, Jia Chai Abdul Hamid, Aini Ismafairus Omar, Hazim Abdul Rahman, Muhammad Riddha Fitzrol, Diana Noma Idris, Zamzuri Ghani, Abdul Rahman Izaini Wan Mohamad, Wan Nor Azlen Mustafar, Faiz Hanafi, Muhammad Hafiz Kandasamy, Regunath Abdullah, Mohd Zaid Amaruchkul, Kannapha Valdes-Sosa, Pedro Bringas-Vega, Maria Biswal, Bharat Songsiri, Jitkomut Yaacob, Hamwira Sakti Ibrahim, Haidi Sumari, Putra Noh, Nor Azila Musa, Kamarul Imran Ahmad, Asma Hayati Azman, Azlinda Jamir Singh, Paramjit Singh Othman, Azizah Abdullah, Jafri Malin |
| author_facet |
Wen, Jia Chai Abdul Hamid, Aini Ismafairus Omar, Hazim Abdul Rahman, Muhammad Riddha Fitzrol, Diana Noma Idris, Zamzuri Ghani, Abdul Rahman Izaini Wan Mohamad, Wan Nor Azlen Mustafar, Faiz Hanafi, Muhammad Hafiz Kandasamy, Regunath Abdullah, Mohd Zaid Amaruchkul, Kannapha Valdes-Sosa, Pedro Bringas-Vega, Maria Biswal, Bharat Songsiri, Jitkomut Yaacob, Hamwira Sakti Ibrahim, Haidi Sumari, Putra Noh, Nor Azila Musa, Kamarul Imran Ahmad, Asma Hayati Azman, Azlinda Jamir Singh, Paramjit Singh Othman, Azizah Abdullah, Jafri Malin |
| author_sort |
Wen, Jia Chai |
| title |
Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| title_short |
Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| title_full |
Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| title_fullStr |
Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| title_full_unstemmed |
Neural alterations in working memory of mild-moderate TBI: an fMRI study in Malaysia |
| title_sort |
neural alterations in working memory of mild-moderate tbi: an fmri study in malaysia |
| publisher |
John Wiley and Sons Inc |
| publishDate |
2022 |
| url |
http://irep.iium.edu.my/98902/7/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI.pdf http://irep.iium.edu.my/98902/8/98902_Neural%20alterations%20in%20working%20memory%20of%20mild-moderate%20TBI_Scopus.pdf http://irep.iium.edu.my/98902/ https://onlinelibrary.wiley.com/doi/10.1002/jnr.25023 |
| _version_ |
1739827890301698048 |
| score |
13.211869 |