Staff View: The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence

The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence

Objectives The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods The eel mucu...

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Main Authors:	Hilles, Ayah Rebhi, Syed, Mahmood, I. Waly, Mostafa, Kaderi, Mohd Arifin, Ahmed, Qamar Uddin, Hejaz Azmi, Syed Najmul, F. AlAsmari, Abdullah, Ali, Nemat, Alharbi, Metab, Rauf, Mohd Ahmar
Format:	Article
Language:	English English
Published:	Elsevier 2022
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/97920/7/97920_The%20therapeutic%20potential%20of%20skin%20mucus%20from%20Asian%20swamp%20eel.pdf http://irep.iium.edu.my/97920/13/97920_The%20therapeutic%20potential%20of%20skin%20mucus_SCOPUS.pdf http://irep.iium.edu.my/97920/ https://www.journals.elsevier.com/journal-of-king-saud-university-science
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spelling	my.iium.irep.979202022-06-03T02:31:08Z http://irep.iium.edu.my/97920/ The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence Hilles, Ayah Rebhi Syed, Mahmood I. Waly, Mostafa Kaderi, Mohd Arifin Ahmed, Qamar Uddin Hejaz Azmi, Syed Najmul F. AlAsmari, Abdullah Ali, Nemat Alharbi, Metab Rauf, Mohd Ahmar Q Science (General) QD Chemistry Objectives The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods The eel mucus was collected fleshly and topical gel with carbopol 934 was formulated to study the antibacterial activity on the infected skin of the rats. Sprague Dawley rats were used in the study and divided into 4 groups negative, positive, normal control, and treated groups. Results Intracutaneous injections of pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus) and fungi (Microsporum gypseum, Candida albicans) were injected into the rats. The development of tinea capitis, impetigo, and cutaneous candidiasis in the animal model was confirmed based on clinical and histopathological observations. To treat the infected rats, a formulated gel of eel skin mucus was applied on the infected rat’s skins topically. The histological analysis confirms a complete recovery in the skin tissues similar to commercial antifungal and antibacterial agents used in the positive control groups. Conclusion The present novel eel skin mucus is an efficient therapeutic candidate in treating skin infections associated with pathogenic microbes. Elsevier 2022-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/97920/7/97920_The%20therapeutic%20potential%20of%20skin%20mucus%20from%20Asian%20swamp%20eel.pdf application/pdf en http://irep.iium.edu.my/97920/13/97920_The%20therapeutic%20potential%20of%20skin%20mucus_SCOPUS.pdf Hilles, Ayah Rebhi and Syed, Mahmood and I. Waly, Mostafa and Kaderi, Mohd Arifin and Ahmed, Qamar Uddin and Hejaz Azmi, Syed Najmul and F. AlAsmari, Abdullah and Ali, Nemat and Alharbi, Metab and Rauf, Mohd Ahmar (2022) The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence. Journal of King Saud University – Science, 34 (4). p. 102011. ISSN 1018-3647 https://www.journals.elsevier.com/journal-of-king-saud-university-science doi.org/10.1016/j.jksus.2022.102011
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Hilles, Ayah Rebhi Syed, Mahmood I. Waly, Mostafa Kaderi, Mohd Arifin Ahmed, Qamar Uddin Hejaz Azmi, Syed Najmul F. AlAsmari, Abdullah Ali, Nemat Alharbi, Metab Rauf, Mohd Ahmar The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
description	Objectives The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods The eel mucus was collected fleshly and topical gel with carbopol 934 was formulated to study the antibacterial activity on the infected skin of the rats. Sprague Dawley rats were used in the study and divided into 4 groups negative, positive, normal control, and treated groups. Results Intracutaneous injections of pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus) and fungi (Microsporum gypseum, Candida albicans) were injected into the rats. The development of tinea capitis, impetigo, and cutaneous candidiasis in the animal model was confirmed based on clinical and histopathological observations. To treat the infected rats, a formulated gel of eel skin mucus was applied on the infected rat’s skins topically. The histological analysis confirms a complete recovery in the skin tissues similar to commercial antifungal and antibacterial agents used in the positive control groups. Conclusion The present novel eel skin mucus is an efficient therapeutic candidate in treating skin infections associated with pathogenic microbes.
format	Article
author	Hilles, Ayah Rebhi Syed, Mahmood I. Waly, Mostafa Kaderi, Mohd Arifin Ahmed, Qamar Uddin Hejaz Azmi, Syed Najmul F. AlAsmari, Abdullah Ali, Nemat Alharbi, Metab Rauf, Mohd Ahmar
author_facet	Hilles, Ayah Rebhi Syed, Mahmood I. Waly, Mostafa Kaderi, Mohd Arifin Ahmed, Qamar Uddin Hejaz Azmi, Syed Najmul F. AlAsmari, Abdullah Ali, Nemat Alharbi, Metab Rauf, Mohd Ahmar
author_sort	Hilles, Ayah Rebhi
title	The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
title_short	The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
title_full	The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
title_fullStr	The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
title_full_unstemmed	The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence
title_sort	therapeutic potential of skin mucus from asian swamp eel (monopterus albus): in vivo evaluation and histological evidence
publisher	Elsevier
publishDate	2022
url	http://irep.iium.edu.my/97920/7/97920_The%20therapeutic%20potential%20of%20skin%20mucus%20from%20Asian%20swamp%20eel.pdf http://irep.iium.edu.my/97920/13/97920_The%20therapeutic%20potential%20of%20skin%20mucus_SCOPUS.pdf http://irep.iium.edu.my/97920/ https://www.journals.elsevier.com/journal-of-king-saud-university-science
_version_	1735386634441981952
score	13.211869

The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence

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