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Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation

According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a signiﬁcant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistan...

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Main Authors:	Shamsudin, Nur Farisya, Ahmed, Qamar Uddin, Mahmood, Syed, Shah, Syed Adnan Ali, Khatib, Alfi, Mukhtar, Sayeed, Alsharif, Meshari A., Parveen, Humaira, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English
Published:	Multidisciplinary Digital Publishing Institute (MDPI) 2022
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/97913/7/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity_SCOPUS.pdf http://irep.iium.edu.my/97913/8/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity.pdf http://irep.iium.edu.my/97913/ https://www.mdpi.com/1420-3049/27/4/1149/pdf?version=1644377368 https://doi.org/10.3390/molecules27041149
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spelling	my.iium.irep.979132022-05-13T04:03:31Z http://irep.iium.edu.my/97913/ Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation Shamsudin, Nur Farisya Ahmed, Qamar Uddin Mahmood, Syed Shah, Syed Adnan Ali Khatib, Alfi Mukhtar, Sayeed Alsharif, Meshari A. Parveen, Humaira Zakaria, Zainul Amiruddin QD Chemistry According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a signiﬁcant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efﬁciently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of bioﬁlm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, ﬂavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, ﬂavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrugresistant bacteria. The hydroxylation of C5, C7, C30, and C40; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of ﬂavonoids. On the other hand, methoxylation at C30 and C5 has been reported to decrease ﬂavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of ﬂavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products. Multidisciplinary Digital Publishing Institute (MDPI) 2022-02-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/97913/7/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/97913/8/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity.pdf Shamsudin, Nur Farisya and Ahmed, Qamar Uddin and Mahmood, Syed and Shah, Syed Adnan Ali and Khatib, Alfi and Mukhtar, Sayeed and Alsharif, Meshari A. and Parveen, Humaira and Zakaria, Zainul Amiruddin (2022) Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation. Molecules, 27 (4). pp. 1-43. ISSN 1420-3049 https://www.mdpi.com/1420-3049/27/4/1149/pdf?version=1644377368 https://doi.org/10.3390/molecules27041149
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Shamsudin, Nur Farisya Ahmed, Qamar Uddin Mahmood, Syed Shah, Syed Adnan Ali Khatib, Alfi Mukhtar, Sayeed Alsharif, Meshari A. Parveen, Humaira Zakaria, Zainul Amiruddin Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
description	According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a signiﬁcant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efﬁciently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of bioﬁlm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, ﬂavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, ﬂavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrugresistant bacteria. The hydroxylation of C5, C7, C30, and C40; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of ﬂavonoids. On the other hand, methoxylation at C30 and C5 has been reported to decrease ﬂavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of ﬂavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products.
format	Article
author	Shamsudin, Nur Farisya Ahmed, Qamar Uddin Mahmood, Syed Shah, Syed Adnan Ali Khatib, Alfi Mukhtar, Sayeed Alsharif, Meshari A. Parveen, Humaira Zakaria, Zainul Amiruddin
author_facet	Shamsudin, Nur Farisya Ahmed, Qamar Uddin Mahmood, Syed Shah, Syed Adnan Ali Khatib, Alfi Mukhtar, Sayeed Alsharif, Meshari A. Parveen, Humaira Zakaria, Zainul Amiruddin
author_sort	Shamsudin, Nur Farisya
title	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_short	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_full	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_fullStr	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_full_unstemmed	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_sort	antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
publisher	Multidisciplinary Digital Publishing Institute (MDPI)
publishDate	2022
url	http://irep.iium.edu.my/97913/7/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity_SCOPUS.pdf http://irep.iium.edu.my/97913/8/97913_Antibacterial%20effects%20of%20flavonoids%20and%20their%20structure-activity.pdf http://irep.iium.edu.my/97913/ https://www.mdpi.com/1420-3049/27/4/1149/pdf?version=1644377368 https://doi.org/10.3390/molecules27041149
_version_	1732945026081619968
score	13.211869

Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation

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