Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study

Background: Extended spectrum beta-lactamase (ESBL) pathogens are associated with morbidity and mortality. There is a paucity of data describing the treatments and outcomes of ESBL infections in Malaysia. This study evaluated the treatments, mortality and associated factors among patients hospitaliz...

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Main Authors: Abubakar, Usman, Tangiisuran, Balamurugan, Elnaem, Mohamed Hassan Abdelaziz, Sulaiman, Syed Azhar, Khan, Faiz Ullah
Format: Article
Language:English
English
Published: Springer Open 2022
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Online Access:http://irep.iium.edu.my/96725/7/96725_Mortality%20and%20its%20predictors%20among%20hospitalized%20patients.pdf
http://irep.iium.edu.my/96725/8/WOS%20Index.pdf
http://irep.iium.edu.my/96725/
https://fjps.springeropen.com/articles/10.1186/s43094-022-00406-8
https://doi.org/10.1186/s43094-022-00406-8
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spelling my.iium.irep.967252022-07-15T00:32:43Z http://irep.iium.edu.my/96725/ Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study Abubakar, Usman Tangiisuran, Balamurugan Elnaem, Mohamed Hassan Abdelaziz Sulaiman, Syed Azhar Khan, Faiz Ullah R Medicine (General) RS Pharmacy and materia medica Background: Extended spectrum beta-lactamase (ESBL) pathogens are associated with morbidity and mortality. There is a paucity of data describing the treatments and outcomes of ESBL infections in Malaysia. This study evaluated the treatments, mortality and associated factors among patients hospitalized with infections due to ESBL positive enterobacteriaceae. This is a retrospective study conducted in a tertiary hospital from January 2018 to June 2020. Hospitalized patients with ESBL-positive enterobacteriaceae infections were included. A clinical pharmacist collected data by reviewing the patients’ electronic medical records. The data were analysed using both descriptive and inferential analyses. Results: This analysis included 110 patients with a mean age of 62.1±14.4 years. Klebsiella pneumoniae (53.6%) and Escherichia coli (40.9%) were the most prevalent pathogens among the 110 infections. Bacteremia (42.7%) was the most frequent diagnosis. The isolates were resistant to majority of penicillins and cephalosporins. However, over a third (39.3%) were susceptible to piperacillin–tazobactam, while carbapenem susceptibility was extremely high (≥99%). The most frequently used empiric and defnitive antibiotics was piperacillin–tazobactam and meropenem, respectively. Less than a third (28.2%) of patients received active empiric antibiotics, and the mean duration before active antibiotics was 3.9±2.7. Overall, hospital mortality rate was 13.6%, and mortality was signifcantly associated with ICU admission (AOR 8.75; 95% CI 1.05–72.75; P=0.045) and diabetes mellitus (AOR 9.85; 95% CI 1.04–93.09; P=0.046). Conclusions: Carbapenems are the major antibiotics used to treat ESBL-positive enterobacteriaceae infections. Hospital mortality rate is relatively high and is signifcantly associated with in patients admitted to ICU and those with diabetes mellitus. Antibiotic stewardship interventions are necessary to promote early administration of active antibiotics and to reduce overuse of carbapenem antibiotics. Springer Open 2022-02-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/96725/7/96725_Mortality%20and%20its%20predictors%20among%20hospitalized%20patients.pdf application/pdf en http://irep.iium.edu.my/96725/8/WOS%20Index.pdf Abubakar, Usman and Tangiisuran, Balamurugan and Elnaem, Mohamed Hassan Abdelaziz and Sulaiman, Syed Azhar and Khan, Faiz Ullah (2022) Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study. Future Journal of Pharmaceutical Sciences, 8 (17). ISSN 2314-7245 E-ISSN 2314-7253 https://fjps.springeropen.com/articles/10.1186/s43094-022-00406-8 https://doi.org/10.1186/s43094-022-00406-8
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
RS Pharmacy and materia medica
spellingShingle R Medicine (General)
RS Pharmacy and materia medica
Abubakar, Usman
Tangiisuran, Balamurugan
Elnaem, Mohamed Hassan Abdelaziz
Sulaiman, Syed Azhar
Khan, Faiz Ullah
Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
description Background: Extended spectrum beta-lactamase (ESBL) pathogens are associated with morbidity and mortality. There is a paucity of data describing the treatments and outcomes of ESBL infections in Malaysia. This study evaluated the treatments, mortality and associated factors among patients hospitalized with infections due to ESBL positive enterobacteriaceae. This is a retrospective study conducted in a tertiary hospital from January 2018 to June 2020. Hospitalized patients with ESBL-positive enterobacteriaceae infections were included. A clinical pharmacist collected data by reviewing the patients’ electronic medical records. The data were analysed using both descriptive and inferential analyses. Results: This analysis included 110 patients with a mean age of 62.1±14.4 years. Klebsiella pneumoniae (53.6%) and Escherichia coli (40.9%) were the most prevalent pathogens among the 110 infections. Bacteremia (42.7%) was the most frequent diagnosis. The isolates were resistant to majority of penicillins and cephalosporins. However, over a third (39.3%) were susceptible to piperacillin–tazobactam, while carbapenem susceptibility was extremely high (≥99%). The most frequently used empiric and defnitive antibiotics was piperacillin–tazobactam and meropenem, respectively. Less than a third (28.2%) of patients received active empiric antibiotics, and the mean duration before active antibiotics was 3.9±2.7. Overall, hospital mortality rate was 13.6%, and mortality was signifcantly associated with ICU admission (AOR 8.75; 95% CI 1.05–72.75; P=0.045) and diabetes mellitus (AOR 9.85; 95% CI 1.04–93.09; P=0.046). Conclusions: Carbapenems are the major antibiotics used to treat ESBL-positive enterobacteriaceae infections. Hospital mortality rate is relatively high and is signifcantly associated with in patients admitted to ICU and those with diabetes mellitus. Antibiotic stewardship interventions are necessary to promote early administration of active antibiotics and to reduce overuse of carbapenem antibiotics.
format Article
author Abubakar, Usman
Tangiisuran, Balamurugan
Elnaem, Mohamed Hassan Abdelaziz
Sulaiman, Syed Azhar
Khan, Faiz Ullah
author_facet Abubakar, Usman
Tangiisuran, Balamurugan
Elnaem, Mohamed Hassan Abdelaziz
Sulaiman, Syed Azhar
Khan, Faiz Ullah
author_sort Abubakar, Usman
title Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
title_short Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
title_full Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
title_fullStr Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
title_full_unstemmed Mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in Malaysia: a retrospective observational study
title_sort mortality and its predictors among hospitalized patients with infections due to extended spectrum beta-lactamase (esbl) enterobacteriaceae in malaysia: a retrospective observational study
publisher Springer Open
publishDate 2022
url http://irep.iium.edu.my/96725/7/96725_Mortality%20and%20its%20predictors%20among%20hospitalized%20patients.pdf
http://irep.iium.edu.my/96725/8/WOS%20Index.pdf
http://irep.iium.edu.my/96725/
https://fjps.springeropen.com/articles/10.1186/s43094-022-00406-8
https://doi.org/10.1186/s43094-022-00406-8
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