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Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia

INTRODUCTION: Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity and has an essential role in neurodevelopment. Collected evidence sug...

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Main Authors: Tokhi, Elham, Abd. Rahim, Nour El Huda, A.Talib, Norlelawati, Mohd Noor, Hanisah, Ku Zaifah, Norsidah
Format: Article
Language:English
Published: IIUM Press 2022
Subjects:
R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://irep.iium.edu.my/96413/1/96413_Brain%20derived%20neurotrophic%20factor.pdf
http://irep.iium.edu.my/96413/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/1840/1280
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spelling my.iium.irep.964132022-01-24T03:39:27Z http://irep.iium.edu.my/96413/ Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia Tokhi, Elham Abd. Rahim, Nour El Huda A.Talib, Norlelawati Mohd Noor, Hanisah Ku Zaifah, Norsidah R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry INTRODUCTION: Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity and has an essential role in neurodevelopment. Collected evidence suggests that epigenetic changes in the BDNF gene are related to the pathophysiology of psychiatric disorders such as schizophrenia. Therefore, the aim of this study was to assess the association of BDNF DNA methylation with schizophrenia. In addition, the relationship between BDNF DNA methylation and antipsychotics was studied. MATERIALS AND METHODS: Overall, 118 (88 male and 30 female) schizophrenia patients and 122 (92 male and 30 female) healthy controls were included in the study and methylation status was investigated using the Methylight Taqman® assay. RESULTS: There was no significant change in the DNA methylation status between schizophrenia patients and controls in this study despite its increased level (p=0.073). However, DNA methylation level was associated with sex and the difference was more significantly prominent in the male subjects (p=0.016). In addition, BDNF DNA methylation showed a positive significant correlation with the positive symptoms (p=0.032) of schizophrenia and antipsychotics use (p=0.013). CONCLUSION: The BDNF DNA methylation could be affected by gender and has a clinical association. IIUM Press 2022-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/96413/1/96413_Brain%20derived%20neurotrophic%20factor.pdf Tokhi, Elham and Abd. Rahim, Nour El Huda and A.Talib, Norlelawati and Mohd Noor, Hanisah and Ku Zaifah, Norsidah (2022) Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia. IIUM Medical Journal Malaysia (IMJM), 21 (1). pp. 99-106. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom/index.php/imjm/article/view/1840/1280 10.31436/imjm.v21i1.1840
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Tokhi, Elham
Abd. Rahim, Nour El Huda
A.Talib, Norlelawati
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
description INTRODUCTION: Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity and has an essential role in neurodevelopment. Collected evidence suggests that epigenetic changes in the BDNF gene are related to the pathophysiology of psychiatric disorders such as schizophrenia. Therefore, the aim of this study was to assess the association of BDNF DNA methylation with schizophrenia. In addition, the relationship between BDNF DNA methylation and antipsychotics was studied. MATERIALS AND METHODS: Overall, 118 (88 male and 30 female) schizophrenia patients and 122 (92 male and 30 female) healthy controls were included in the study and methylation status was investigated using the Methylight Taqman® assay. RESULTS: There was no significant change in the DNA methylation status between schizophrenia patients and controls in this study despite its increased level (p=0.073). However, DNA methylation level was associated with sex and the difference was more significantly prominent in the male subjects (p=0.016). In addition, BDNF DNA methylation showed a positive significant correlation with the positive symptoms (p=0.032) of schizophrenia and antipsychotics use (p=0.013). CONCLUSION: The BDNF DNA methylation could be affected by gender and has a clinical association.
format Article
author Tokhi, Elham
Abd. Rahim, Nour El Huda
A.Talib, Norlelawati
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
author_facet Tokhi, Elham
Abd. Rahim, Nour El Huda
A.Talib, Norlelawati
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
author_sort Tokhi, Elham
title Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
title_short Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
title_full Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
title_fullStr Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
title_full_unstemmed Brain derived neurotrophic factor (BDNF) gene in peripheral blood cells of Stable Schizophrenia
title_sort brain derived neurotrophic factor (bdnf) gene in peripheral blood cells of stable schizophrenia
publisher IIUM Press
publishDate 2022
url http://irep.iium.edu.my/96413/1/96413_Brain%20derived%20neurotrophic%20factor.pdf
http://irep.iium.edu.my/96413/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/1840/1280
_version_ 1724072845479247872
score 13.211869

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