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The role of DRD4 DNA methylation in schizophrenia

Introduction: DRD4 is a dopamine receptor subtype that has been linked to schizophrenia genetically. Previous studies have shown that the density of DRD4 in schizophrenics' brains was higher than the other dopamine receptors. However, the genetic research of DRD4 in the physiology of the dopami...

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Main Authors: Abd. Rahim, Nour El Huda, Rahim Mohd, Nabil Fikri, Ku Zaifah, Norsidah, Mohd Noor, Hanisah, Abdull Jalil, Mohd Asyraf, A.Talib, Norlelawati
Format: Conference or Workshop Item
Language:English
English
English
English
Published: 2021
Subjects:
R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://irep.iium.edu.my/95393/1/MRS-2021-Abstract-Book-.pdf
http://irep.iium.edu.my/95393/2/MRS-2021-Programme-Book.pdf
http://irep.iium.edu.my/95393/3/MRS2021-THE%20ROLE%20OF%20DRD4%20DNA%20METHYLATION%20IN%20SCHIZOPHRENIA.pdf
http://irep.iium.edu.my/95393/4/PNC187_NEH_DRD4_SUBMIT.pdf
http://irep.iium.edu.my/95393/
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spelling my.iium.irep.953932021-12-28T14:55:32Z http://irep.iium.edu.my/95393/ The role of DRD4 DNA methylation in schizophrenia Abd. Rahim, Nour El Huda Rahim Mohd, Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdull Jalil, Mohd Asyraf A.Talib, Norlelawati R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Introduction: DRD4 is a dopamine receptor subtype that has been linked to schizophrenia genetically. Previous studies have shown that the density of DRD4 in schizophrenics' brains was higher than the other dopamine receptors. However, the genetic research of DRD4 in the physiology of the dopaminergic system with increased risk of schizophrenia is still not well established. Due to the complexity of the gene variations associated with schizophrenia and the influence of environmental factors, the study aimed to analyse the DRD4 DNA methylation in the peripheral blood of schizophrenia. Materials and Methods: This study was a casecontrol study. A total of 138 schizophrenia patients were recruited from the Psychiatry Clinic, Hospital Kuantan Ampuan Afzan, Kuantan Pahang and 132 matched healthy controls were included from Kuantan district. The genomic DNA from the peripheral blood was extracted and bisulfite converted. The MethyLight Taqman® test was used to determine the degree of DRD4 DNA methylation quantitatively. The data was analysed using analysis of covariance (ANCOVA) after being adjusted for age and gender. Results: When compared to the control group, schizophrenia had significantly lower DRD4 DNA methylation (p=0.001). Males (p=0.026) and females (p=0.004) patients both had hypomethylation. Conclusion: This research strongly suggests that DNA methylation of the DRD4 gene may have a role in the genetic foundation of schizophrenia. 2021-12-14 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/95393/1/MRS-2021-Abstract-Book-.pdf application/pdf en http://irep.iium.edu.my/95393/2/MRS-2021-Programme-Book.pdf application/pdf en http://irep.iium.edu.my/95393/3/MRS2021-THE%20ROLE%20OF%20DRD4%20DNA%20METHYLATION%20IN%20SCHIZOPHRENIA.pdf application/pdf en http://irep.iium.edu.my/95393/4/PNC187_NEH_DRD4_SUBMIT.pdf Abd. Rahim, Nour El Huda and Rahim Mohd, Nabil Fikri and Ku Zaifah, Norsidah and Mohd Noor, Hanisah and Abdull Jalil, Mohd Asyraf and A.Talib, Norlelawati (2021) The role of DRD4 DNA methylation in schizophrenia. In: Medical Research Symposium 2021, 14 December 2021, Kuantan, Pahang. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
English
topic R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle R Medicine (General)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Abd. Rahim, Nour El Huda
Rahim Mohd, Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdull Jalil, Mohd Asyraf
A.Talib, Norlelawati
The role of DRD4 DNA methylation in schizophrenia
description Introduction: DRD4 is a dopamine receptor subtype that has been linked to schizophrenia genetically. Previous studies have shown that the density of DRD4 in schizophrenics' brains was higher than the other dopamine receptors. However, the genetic research of DRD4 in the physiology of the dopaminergic system with increased risk of schizophrenia is still not well established. Due to the complexity of the gene variations associated with schizophrenia and the influence of environmental factors, the study aimed to analyse the DRD4 DNA methylation in the peripheral blood of schizophrenia. Materials and Methods: This study was a casecontrol study. A total of 138 schizophrenia patients were recruited from the Psychiatry Clinic, Hospital Kuantan Ampuan Afzan, Kuantan Pahang and 132 matched healthy controls were included from Kuantan district. The genomic DNA from the peripheral blood was extracted and bisulfite converted. The MethyLight Taqman® test was used to determine the degree of DRD4 DNA methylation quantitatively. The data was analysed using analysis of covariance (ANCOVA) after being adjusted for age and gender. Results: When compared to the control group, schizophrenia had significantly lower DRD4 DNA methylation (p=0.001). Males (p=0.026) and females (p=0.004) patients both had hypomethylation. Conclusion: This research strongly suggests that DNA methylation of the DRD4 gene may have a role in the genetic foundation of schizophrenia.
format Conference or Workshop Item
author Abd. Rahim, Nour El Huda
Rahim Mohd, Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdull Jalil, Mohd Asyraf
A.Talib, Norlelawati
author_facet Abd. Rahim, Nour El Huda
Rahim Mohd, Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdull Jalil, Mohd Asyraf
A.Talib, Norlelawati
author_sort Abd. Rahim, Nour El Huda
title The role of DRD4 DNA methylation in schizophrenia
title_short The role of DRD4 DNA methylation in schizophrenia
title_full The role of DRD4 DNA methylation in schizophrenia
title_fullStr The role of DRD4 DNA methylation in schizophrenia
title_full_unstemmed The role of DRD4 DNA methylation in schizophrenia
title_sort role of drd4 dna methylation in schizophrenia
publishDate 2021
url http://irep.iium.edu.my/95393/1/MRS-2021-Abstract-Book-.pdf
http://irep.iium.edu.my/95393/2/MRS-2021-Programme-Book.pdf
http://irep.iium.edu.my/95393/3/MRS2021-THE%20ROLE%20OF%20DRD4%20DNA%20METHYLATION%20IN%20SCHIZOPHRENIA.pdf
http://irep.iium.edu.my/95393/4/PNC187_NEH_DRD4_SUBMIT.pdf
http://irep.iium.edu.my/95393/
_version_ 1720436688870703104
score 13.211869

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