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Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients

OBJECTIVE: The objective of this study was to evaluate the Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) in tears in age related macular degeneration (AMD) patients and to determine its associated factors. METHODS: This was a comparative cross-sectional study. Patients with Early AMD...

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Main Author: Rosli, Abdul Hadi
Format: Conference or Workshop Item
Language:English
English
Published: 2021
Subjects:
RE Ophthalmology
Online Access:http://irep.iium.edu.my/94735/1/APVRS%20Abdul-Hadi%20Rosli%20PDF.pdf
http://irep.iium.edu.my/94735/7/Abstracts%20%E2%80%93%20APVRS%202021.pdf
http://irep.iium.edu.my/94735/
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spelling my.iium.irep.947352021-12-24T04:30:19Z http://irep.iium.edu.my/94735/ Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients Rosli, Abdul Hadi RE Ophthalmology OBJECTIVE: The objective of this study was to evaluate the Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) in tears in age related macular degeneration (AMD) patients and to determine its associated factors. METHODS: This was a comparative cross-sectional study. Patients with Early AMD, Late AMD and Control group whom fulfilled the inclusion criteria were recruited into this study. Tears samples were collected, then analysed using commercial Human IL-6 and TNF-α enzyme-linked immunosorbent assay kit to measure IL-6 and TNF-α levels in tears. Only late neovascular AMD (nAMD) was enrolled in this study since there was no late dry AMD available during the study period. RESULTS: A total of 142 patients (56 early AMD, 56 late nAMD and 30 Control group) were recruited in this study. AMD showed significantly higher mean tears IL-6 (21.91 (95%CI: 19.89, 23.93), p= 0.014) compared to control group after adjusted with covariates. However there was no significant difference of mean tears IL-6 between early and late nAMD group after adjusted with covariates (p=0.844). For TNF-α, there was no significant differences of mean tears TNF- α between AMD and control group as well as between early and late nAMD after adjusted with covariates (p=0.324 and p=0.749 respectively). There was no significant association found between IL-6 and TNF-α level in tears with duration of AMD, serum level of IL-6 and TNF-α, smoking status and AMD status. CONLUSION: IL-6 in tears showed significant elevation among AMD. Therefore, IL-6 in tears can be used as non-invasive biomarker for AMD screening. 2021-12-12 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/94735/1/APVRS%20Abdul-Hadi%20Rosli%20PDF.pdf application/pdf en http://irep.iium.edu.my/94735/7/Abstracts%20%E2%80%93%20APVRS%202021.pdf Rosli, Abdul Hadi (2021) Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients. In: 14th Asia Pacific Vitreo-Retinal Society Congress 2021, 11-12 December 2021, Virtual Conference. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RE Ophthalmology
spellingShingle RE Ophthalmology
Rosli, Abdul Hadi
Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
description OBJECTIVE: The objective of this study was to evaluate the Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) in tears in age related macular degeneration (AMD) patients and to determine its associated factors. METHODS: This was a comparative cross-sectional study. Patients with Early AMD, Late AMD and Control group whom fulfilled the inclusion criteria were recruited into this study. Tears samples were collected, then analysed using commercial Human IL-6 and TNF-α enzyme-linked immunosorbent assay kit to measure IL-6 and TNF-α levels in tears. Only late neovascular AMD (nAMD) was enrolled in this study since there was no late dry AMD available during the study period. RESULTS: A total of 142 patients (56 early AMD, 56 late nAMD and 30 Control group) were recruited in this study. AMD showed significantly higher mean tears IL-6 (21.91 (95%CI: 19.89, 23.93), p= 0.014) compared to control group after adjusted with covariates. However there was no significant difference of mean tears IL-6 between early and late nAMD group after adjusted with covariates (p=0.844). For TNF-α, there was no significant differences of mean tears TNF- α between AMD and control group as well as between early and late nAMD after adjusted with covariates (p=0.324 and p=0.749 respectively). There was no significant association found between IL-6 and TNF-α level in tears with duration of AMD, serum level of IL-6 and TNF-α, smoking status and AMD status. CONLUSION: IL-6 in tears showed significant elevation among AMD. Therefore, IL-6 in tears can be used as non-invasive biomarker for AMD screening.
format Conference or Workshop Item
author Rosli, Abdul Hadi
author_facet Rosli, Abdul Hadi
author_sort Rosli, Abdul Hadi
title Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
title_short Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
title_full Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
title_fullStr Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
title_full_unstemmed Evaluation of interleukin-6 and Tumor Necrosis Factor- Alpha in tears and its associated factors in age-related macular degeneration patients
title_sort evaluation of interleukin-6 and tumor necrosis factor- alpha in tears and its associated factors in age-related macular degeneration patients
publishDate 2021
url http://irep.iium.edu.my/94735/1/APVRS%20Abdul-Hadi%20Rosli%20PDF.pdf
http://irep.iium.edu.my/94735/7/Abstracts%20%E2%80%93%20APVRS%202021.pdf
http://irep.iium.edu.my/94735/
_version_ 1720436650684710912
score 13.211869

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