Staff View: AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults

AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults

Background/ Objective: The renin-angiotensin-aldosterone system is implicated in sodium balance and blood pressure regulation. Angiotensin II binding to Angiotensin 2 Type 1 receptor (AGTR1) eventually leads to sodium and water retention which may cause an increase in blood pressure. While hypomethy...

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Main Authors:	Wan Omar, Wan Fatein Nabeila, Abdullah, Aszrin, A.Talib, Norlelawati, Mohamed Bakrim, Norbaiyah
Format:	Conference or Workshop Item
Language:	English English English
Published:	Korean Endocrine Society 2021
Subjects:	QH426 Genetics QP Physiology RA643 Communicable Diseases and Public Health RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Online Access:	http://irep.iium.edu.my/93639/2/SICEM%20Program%20book.pdf http://irep.iium.edu.my/93639/20/93639_SICEM2021_OF0135%20Poster%20Wan%20Fatein.pdf http://irep.iium.edu.my/93639/26/PDF%20SICEM%202021%20abstract%20page%20.pdf http://irep.iium.edu.my/93639/
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spelling	my.iium.irep.936392022-01-28T06:25:34Z http://irep.iium.edu.my/93639/ AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults Wan Omar, Wan Fatein Nabeila Abdullah, Aszrin A.Talib, Norlelawati Mohamed Bakrim, Norbaiyah QH426 Genetics QP Physiology RA643 Communicable Diseases and Public Health RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Background/ Objective: The renin-angiotensin-aldosterone system is implicated in sodium balance and blood pressure regulation. Angiotensin II binding to Angiotensin 2 Type 1 receptor (AGTR1) eventually leads to sodium and water retention which may cause an increase in blood pressure. While hypomethylation of AGTR1 has been described in hypertensive animals and humans, its role in premature hypertension has yet to be defined. This study aimed to assess AGTR1 methylation level in young adults with prehypertension and hypertension. Methods: This study protocol was approved by the Ministry of Health Medical Research Ethical Committee (NMRR-16-2572-32869). In this observational, comparative, cross-sectional study, we extracted leukocytic DNA from 240 young adults age 18-45 years in Kuantan with normal blood pressure (Nt), prehypertension (Pre), and newly-diagnosed hypertension (Hpt), with n = 80 for each group. The blood pressure classification followed Clinical Practice Guideline Management of Hypertension 4th edition by Ministry of Health Malaysia. We measured the DNA methylation level of AGTR1 using the MethyLight protocol. We analysed the data using IBM SPSS Statistics 26 (IBM, New York). Results: AGTR1 methylation ranged between 1.083 to 1.189. We found no significant correlation between AGTR1 methylation and the haemodynamic parameters (p = 0.130 – 0.886). Although there was a decreasing trend in AGTR1 methylation from Nt to Pre to Hpt, there was the difference was not significant (p = 0.274). Further analyses showed that AGTR1 methylation adjusted for other covariates did not predict prehypertension or hypertension in this population. Conclusion: There was no differential AGTR1 methylation level between young adults with Nt, Pre, and Hpt. Further studies to look at other genes methylation that might contribute to premature prehypertension and hypertension should be done to further understand the epigenetic changes in this population. Korean Endocrine Society 2021-10-28 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/93639/2/SICEM%20Program%20book.pdf application/pdf en http://irep.iium.edu.my/93639/20/93639_SICEM2021_OF0135%20Poster%20Wan%20Fatein.pdf application/pdf en http://irep.iium.edu.my/93639/26/PDF%20SICEM%202021%20abstract%20page%20.pdf Wan Omar, Wan Fatein Nabeila and Abdullah, Aszrin and A.Talib, Norlelawati and Mohamed Bakrim, Norbaiyah (2021) AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults. In: The 9th Seoul International Congress of Endocrinology and Metabolism in conjunction with the 40th Annual Scientific Meeting of the Korean Endocrine Society, 28th - 30th October 2021, Hybrid congress: BPEX (Busan Port International Exhibition & Convention Center) and Virtual. (Unpublished)
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	QH426 Genetics QP Physiology RA643 Communicable Diseases and Public Health RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
spellingShingle	QH426 Genetics QP Physiology RA643 Communicable Diseases and Public Health RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Wan Omar, Wan Fatein Nabeila Abdullah, Aszrin A.Talib, Norlelawati Mohamed Bakrim, Norbaiyah AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
description	Background/ Objective: The renin-angiotensin-aldosterone system is implicated in sodium balance and blood pressure regulation. Angiotensin II binding to Angiotensin 2 Type 1 receptor (AGTR1) eventually leads to sodium and water retention which may cause an increase in blood pressure. While hypomethylation of AGTR1 has been described in hypertensive animals and humans, its role in premature hypertension has yet to be defined. This study aimed to assess AGTR1 methylation level in young adults with prehypertension and hypertension. Methods: This study protocol was approved by the Ministry of Health Medical Research Ethical Committee (NMRR-16-2572-32869). In this observational, comparative, cross-sectional study, we extracted leukocytic DNA from 240 young adults age 18-45 years in Kuantan with normal blood pressure (Nt), prehypertension (Pre), and newly-diagnosed hypertension (Hpt), with n = 80 for each group. The blood pressure classification followed Clinical Practice Guideline Management of Hypertension 4th edition by Ministry of Health Malaysia. We measured the DNA methylation level of AGTR1 using the MethyLight protocol. We analysed the data using IBM SPSS Statistics 26 (IBM, New York). Results: AGTR1 methylation ranged between 1.083 to 1.189. We found no significant correlation between AGTR1 methylation and the haemodynamic parameters (p = 0.130 – 0.886). Although there was a decreasing trend in AGTR1 methylation from Nt to Pre to Hpt, there was the difference was not significant (p = 0.274). Further analyses showed that AGTR1 methylation adjusted for other covariates did not predict prehypertension or hypertension in this population. Conclusion: There was no differential AGTR1 methylation level between young adults with Nt, Pre, and Hpt. Further studies to look at other genes methylation that might contribute to premature prehypertension and hypertension should be done to further understand the epigenetic changes in this population.
format	Conference or Workshop Item
author	Wan Omar, Wan Fatein Nabeila Abdullah, Aszrin A.Talib, Norlelawati Mohamed Bakrim, Norbaiyah
author_facet	Wan Omar, Wan Fatein Nabeila Abdullah, Aszrin A.Talib, Norlelawati Mohamed Bakrim, Norbaiyah
author_sort	Wan Omar, Wan Fatein Nabeila
title	AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
title_short	AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
title_full	AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
title_fullStr	AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
title_full_unstemmed	AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults
title_sort	agtr1 methylation was not predictive of prehypertension or hypertension in young adults
publisher	Korean Endocrine Society
publishDate	2021
url	http://irep.iium.edu.my/93639/2/SICEM%20Program%20book.pdf http://irep.iium.edu.my/93639/20/93639_SICEM2021_OF0135%20Poster%20Wan%20Fatein.pdf http://irep.iium.edu.my/93639/26/PDF%20SICEM%202021%20abstract%20page%20.pdf http://irep.iium.edu.my/93639/
_version_	1724072783182299136
score	13.211869

AGTR1 Methylation was not predictive of prehypertension or hypertension in young adults

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