Staff View: Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic

Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic

Background: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prev...

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Main Authors:	Khalifa, Shaden A. M., Yosri, Nermeen, El-Mallah, Mohamed F, Ghonaim, Reem, Guo, Zhiming, Musharraf, Syed Ghulam, Du, Ming, Khatib, Alfi, Xiao, Jianbo, Saeed, Aamer, El-Seedi, Haged H. R., Zhao, Chao, Efferth, Thomas, El-Seedi, Hesham
Format:	Article
Language:	English English
Published:	Elsevier 2021
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/93039/7/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds_SCOPUS.pdf http://irep.iium.edu.my/93039/8/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds.pdf http://irep.iium.edu.my/93039/ https://www.sciencedirect.com/science/article/pii/S0944711320301434/pdfft?isDTMRedir=true&download=true https://doi.org/10.1016/j.phymed.2020.153311
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spelling	my.iium.irep.930392021-10-15T01:23:50Z http://irep.iium.edu.my/93039/ Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic Khalifa, Shaden A. M. Yosri, Nermeen El-Mallah, Mohamed F Ghonaim, Reem Guo, Zhiming Musharraf, Syed Ghulam Du, Ming Khatib, Alfi Xiao, Jianbo Saeed, Aamer El-Seedi, Haged H. R. Zhao, Chao Efferth, Thomas El-Seedi, Hesham Q Science (General) Background: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge. Methods: A literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar). Results: Through the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L’H´er.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab. Conclusion: Natural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19. Elsevier 2021-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/93039/7/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/93039/8/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds.pdf Khalifa, Shaden A. M. and Yosri, Nermeen and El-Mallah, Mohamed F and Ghonaim, Reem and Guo, Zhiming and Musharraf, Syed Ghulam and Du, Ming and Khatib, Alfi and Xiao, Jianbo and Saeed, Aamer and El-Seedi, Haged H. R. and Zhao, Chao and Efferth, Thomas and El-Seedi, Hesham (2021) Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic. Phytomedicine, 85. ISSN 0944-7113 E-ISSN 1618-095X https://www.sciencedirect.com/science/article/pii/S0944711320301434/pdfft?isDTMRedir=true&download=true https://doi.org/10.1016/j.phymed.2020.153311
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Khalifa, Shaden A. M. Yosri, Nermeen El-Mallah, Mohamed F Ghonaim, Reem Guo, Zhiming Musharraf, Syed Ghulam Du, Ming Khatib, Alfi Xiao, Jianbo Saeed, Aamer El-Seedi, Haged H. R. Zhao, Chao Efferth, Thomas El-Seedi, Hesham Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
description	Background: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge. Methods: A literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar). Results: Through the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L’H´er.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab. Conclusion: Natural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.
format	Article
author	Khalifa, Shaden A. M. Yosri, Nermeen El-Mallah, Mohamed F Ghonaim, Reem Guo, Zhiming Musharraf, Syed Ghulam Du, Ming Khatib, Alfi Xiao, Jianbo Saeed, Aamer El-Seedi, Haged H. R. Zhao, Chao Efferth, Thomas El-Seedi, Hesham
author_facet	Khalifa, Shaden A. M. Yosri, Nermeen El-Mallah, Mohamed F Ghonaim, Reem Guo, Zhiming Musharraf, Syed Ghulam Du, Ming Khatib, Alfi Xiao, Jianbo Saeed, Aamer El-Seedi, Haged H. R. Zhao, Chao Efferth, Thomas El-Seedi, Hesham
author_sort	Khalifa, Shaden A. M.
title	Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
title_short	Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
title_full	Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
title_fullStr	Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
title_full_unstemmed	Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
title_sort	screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic
publisher	Elsevier
publishDate	2021
url	http://irep.iium.edu.my/93039/7/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds_SCOPUS.pdf http://irep.iium.edu.my/93039/8/93039_Screening%20for%20natural%20and%20derived%20bio-active%20compounds.pdf http://irep.iium.edu.my/93039/ https://www.sciencedirect.com/science/article/pii/S0944711320301434/pdfft?isDTMRedir=true&download=true https://doi.org/10.1016/j.phymed.2020.153311
_version_	1715189403570143232
score	13.211869

Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic

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