Cover Image

Pulmonary phaehyphomycosis in retroviral disease patient

Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cytoplasmic melanin-like pigment. A 42-year-old man with underlying retroviral disease on HAART was investigated for having constitutional symptoms. Despite undetectable viral load and a high CD4 count, he...

Full description

Saved in:
Bibliographic Details
Main Authors: Zainulabid, Ummu Afeera, Abdul Azih, Muhammad Naimmuddin, Maniyam, Sasi Kumar, Abd. Fuaat, Azliana, Abidin, Mohd Radhwan, Ahmad, Hajar Fauzan
Format: Article
Language:English
Published: Federation of Islamic Medical Associations (FIMA) 2021
Subjects:
RC Internal medicine
RC111 Infectious and Parasitic Diseases
Online Access:http://irep.iium.edu.my/92609/7/92609%20Pulmonary%20Phaehyphomycosis%20in%20Retroviral%20Disease%20Patient.pdf
http://irep.iium.edu.my/92609/
https://ijhhsfimaweb.info/index.php/IJHHS/article/view/335
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.92609
record_format dspace
spelling my.iium.irep.926092021-10-01T07:43:11Z http://irep.iium.edu.my/92609/ Pulmonary phaehyphomycosis in retroviral disease patient Zainulabid, Ummu Afeera Abdul Azih, Muhammad Naimmuddin Maniyam, Sasi Kumar Abd. Fuaat, Azliana Abidin, Mohd Radhwan Ahmad, Hajar Fauzan RC Internal medicine RC111 Infectious and Parasitic Diseases Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cytoplasmic melanin-like pigment. A 42-year-old man with underlying retroviral disease on HAART was investigated for having constitutional symptoms. Despite undetectable viral load and a high CD4 count, he was found to have unexplained significant loss of weight and appetite over a period of 6 months. Clinical examination revealed a cachexic man with multiple inguinal lymphadenopathies. Excisional biopsy of the inguinal lymph node revealed reactive follicular hyperplasia. CT Thorax, Abdomen and Pelvis was arranged to look for occult malignancy or infection and he was found to have multiple non-enhancing subcentimeter lung nodules mainly at the lateral segment of the right middle lobe of his lung. The largest nodule measured about 0.8 x 1.5 x 0.5 (AP x W x CC), with some nodules having an irregular margin with no extension into the adjacent bronchi. Bronchoscopy was done and demonstrated a black patch at the right intermedius, lateral segment of the middle lobe which did not disappear upon bronchial flush or wash. Histopathological examination found focal areas of blackish pigment and the bronchial alveolar lavage sent for fungal culture grew Cladosporium species. The patient was treated with oral Itraconazole with marked clinical improvement. This case highlights an unusual black fungi infection in the lung that stands out not only for its rarity and it's responsiveness to treatment, but also the susceptibility of an RVD positive patient to this infection despite having suppressed viral load and normal CD4 count. Federation of Islamic Medical Associations (FIMA) 2021 Article PeerReviewed application/pdf en http://irep.iium.edu.my/92609/7/92609%20Pulmonary%20Phaehyphomycosis%20in%20Retroviral%20Disease%20Patient.pdf Zainulabid, Ummu Afeera and Abdul Azih, Muhammad Naimmuddin and Maniyam, Sasi Kumar and Abd. Fuaat, Azliana and Abidin, Mohd Radhwan and Ahmad, Hajar Fauzan (2021) Pulmonary phaehyphomycosis in retroviral disease patient. International Journal of Human and Health Sciences (IJHHS), Supplementary Issue-2: 2021. S17-S17. ISSN 2523-692X https://ijhhsfimaweb.info/index.php/IJHHS/article/view/335 10.31344/ijhhs.v5i0-2.335
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC Internal medicine
RC111 Infectious and Parasitic Diseases
spellingShingle RC Internal medicine
RC111 Infectious and Parasitic Diseases
Zainulabid, Ummu Afeera
Abdul Azih, Muhammad Naimmuddin
Maniyam, Sasi Kumar
Abd. Fuaat, Azliana
Abidin, Mohd Radhwan
Ahmad, Hajar Fauzan
Pulmonary phaehyphomycosis in retroviral disease patient
description Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cytoplasmic melanin-like pigment. A 42-year-old man with underlying retroviral disease on HAART was investigated for having constitutional symptoms. Despite undetectable viral load and a high CD4 count, he was found to have unexplained significant loss of weight and appetite over a period of 6 months. Clinical examination revealed a cachexic man with multiple inguinal lymphadenopathies. Excisional biopsy of the inguinal lymph node revealed reactive follicular hyperplasia. CT Thorax, Abdomen and Pelvis was arranged to look for occult malignancy or infection and he was found to have multiple non-enhancing subcentimeter lung nodules mainly at the lateral segment of the right middle lobe of his lung. The largest nodule measured about 0.8 x 1.5 x 0.5 (AP x W x CC), with some nodules having an irregular margin with no extension into the adjacent bronchi. Bronchoscopy was done and demonstrated a black patch at the right intermedius, lateral segment of the middle lobe which did not disappear upon bronchial flush or wash. Histopathological examination found focal areas of blackish pigment and the bronchial alveolar lavage sent for fungal culture grew Cladosporium species. The patient was treated with oral Itraconazole with marked clinical improvement. This case highlights an unusual black fungi infection in the lung that stands out not only for its rarity and it's responsiveness to treatment, but also the susceptibility of an RVD positive patient to this infection despite having suppressed viral load and normal CD4 count.
format Article
author Zainulabid, Ummu Afeera
Abdul Azih, Muhammad Naimmuddin
Maniyam, Sasi Kumar
Abd. Fuaat, Azliana
Abidin, Mohd Radhwan
Ahmad, Hajar Fauzan
author_facet Zainulabid, Ummu Afeera
Abdul Azih, Muhammad Naimmuddin
Maniyam, Sasi Kumar
Abd. Fuaat, Azliana
Abidin, Mohd Radhwan
Ahmad, Hajar Fauzan
author_sort Zainulabid, Ummu Afeera
title Pulmonary phaehyphomycosis in retroviral disease patient
title_short Pulmonary phaehyphomycosis in retroviral disease patient
title_full Pulmonary phaehyphomycosis in retroviral disease patient
title_fullStr Pulmonary phaehyphomycosis in retroviral disease patient
title_full_unstemmed Pulmonary phaehyphomycosis in retroviral disease patient
title_sort pulmonary phaehyphomycosis in retroviral disease patient
publisher Federation of Islamic Medical Associations (FIMA)
publishDate 2021
url http://irep.iium.edu.my/92609/7/92609%20Pulmonary%20Phaehyphomycosis%20in%20Retroviral%20Disease%20Patient.pdf
http://irep.iium.edu.my/92609/
https://ijhhsfimaweb.info/index.php/IJHHS/article/view/335
_version_ 1713199553625194496
score 13.211869

Similar Items