Cover Image

Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease...

Full description

Saved in:
Bibliographic Details
Main Authors: Mia, Abdur Rashid, Ferdosh, Sahena, Ahmed, Qamar Uddin, Helal Uddin, A.B.M., Sarker, Md. Zaidul Islam
Format: Article
Language:English
Published: Bentham Science Publishers 2021
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/92577/7/92577_Bridging%20indigenous%20knowledge%20and%20scientific%20evidence.pdf
http://irep.iium.edu.my/92577/
https://www.eurekaselect.com/article/115015
https://doi.org/10.2174/2210315511666210322161112
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.92577
record_format dspace
spelling my.iium.irep.925772022-07-07T07:15:59Z http://irep.iium.edu.my/92577/ Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review Mia, Abdur Rashid Ferdosh, Sahena Ahmed, Qamar Uddin Helal Uddin, A.B.M. Sarker, Md. Zaidul Islam Q Science (General) Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne, and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities, thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Methods: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids, etc., were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates anti-diabetic, anti- oxidant, antimicrobial, anticancer, anti-hypercholesterolemia, and antihypertensive activities. Conclusion: Despite various claims, there is still inadequate scientific evidence, particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases, and rheumatoid arthritis, necessitating future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties. Bentham Science Publishers 2021 Article PeerReviewed application/pdf en http://irep.iium.edu.my/92577/7/92577_Bridging%20indigenous%20knowledge%20and%20scientific%20evidence.pdf Mia, Abdur Rashid and Ferdosh, Sahena and Ahmed, Qamar Uddin and Helal Uddin, A.B.M. and Sarker, Md. Zaidul Islam (2021) Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review. The Natural Products Journal. pp. 1-17. ISSN 2210-3155 E-ISSN 2210-3163 https://www.eurekaselect.com/article/115015 https://doi.org/10.2174/2210315511666210322161112
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Mia, Abdur Rashid
Ferdosh, Sahena
Ahmed, Qamar Uddin
Helal Uddin, A.B.M.
Sarker, Md. Zaidul Islam
Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
description Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne, and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities, thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Methods: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids, etc., were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates anti-diabetic, anti- oxidant, antimicrobial, anticancer, anti-hypercholesterolemia, and antihypertensive activities. Conclusion: Despite various claims, there is still inadequate scientific evidence, particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases, and rheumatoid arthritis, necessitating future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties.
format Article
author Mia, Abdur Rashid
Ferdosh, Sahena
Ahmed, Qamar Uddin
Helal Uddin, A.B.M.
Sarker, Md. Zaidul Islam
author_facet Mia, Abdur Rashid
Ferdosh, Sahena
Ahmed, Qamar Uddin
Helal Uddin, A.B.M.
Sarker, Md. Zaidul Islam
author_sort Mia, Abdur Rashid
title Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
title_short Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
title_full Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
title_fullStr Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
title_full_unstemmed Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
title_sort bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review
publisher Bentham Science Publishers
publishDate 2021
url http://irep.iium.edu.my/92577/7/92577_Bridging%20indigenous%20knowledge%20and%20scientific%20evidence.pdf
http://irep.iium.edu.my/92577/
https://www.eurekaselect.com/article/115015
https://doi.org/10.2174/2210315511666210322161112
_version_ 1738510111769362432
score 13.211869

Similar Items