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Drug discovery and development: prospects and challenges

Drug discovery and development is a vital process before a new drug can be introduced for clinical use. Undeniably, the process to produce a single drug that is safe for the human body and effectively treat specific disease without any side effects is lengthy and very costly. It starts from the cur...

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Main Author:	Bakhtiar, M. Taher
Format:	Book
Language:	English English English
Published:	IIUM Press 2021
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/91943/1/Prelim%20pages%202.9.2021.pdf http://irep.iium.edu.my/91943/2/FINAL%20Cover%20Drug%20Development_2.9.2021.pdf http://irep.iium.edu.my/91943/13/91943_Drug%20discovery%20and%20development_prospects%20and%20challenges.pdf http://irep.iium.edu.my/91943/
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spelling	my.iium.irep.919432021-09-03T08:47:45Z http://irep.iium.edu.my/91943/ Drug discovery and development: prospects and challenges Bakhtiar, M. Taher RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Drug discovery and development is a vital process before a new drug can be introduced for clinical use. Undeniably, the process to produce a single drug that is safe for the human body and effectively treat specific disease without any side effects is lengthy and very costly. It starts from the curiosity over an emerging disease or the absence of effective medication and is translated into a scientific and clinical study through various research approaches, such as from jungle-to-bench, from culture-to-vial, and from waste-to-wealth. Since ancient times, humans have produced drugs or medicine from raw plant materials and their extracts to treat various illnesses. Today, the paradigm has shifted from test and trial to a scientific evidence-based approach through experiments and clinical trials. High throughput methods are also crucial tools to speed up the process of drug discovery. Various drugs have been introduced via stringent guidelines and regulations. With the emergence of new diseases, the development of new side effects, and the latest Coronavirus Disease 2019 (COVID-19) outbreak, these experiences and scenarios have taught us how to address the global impact of disease through collaboration and synergistic strategies. As part of the intellectual community, our collective knowledge would be meaningful to contribute to the discovery and development of effective drugs. The main obstacle in drug discovery and development nowadays is related to biological/pharmacological activities and delivery methods. Given this, nanotechnology has provided an impactful approach to drug and vaccine delivery. Certain drugs that possess unwanted side effects can be improved through nanotechnology to reduce their side effect, while their effective constituent can be delivered to the specific site in a very effective manner. Furthermore, the development of nanocarriers, such as nanovesicles, nanoemulsions, and polymers, has become a global interest due to its ability to increase, protect, and encapsulate drugs, ultimately increasing the efficacy of drug delivery. Therefore, drug discovery and development require a continuous supply of innovative ideas, effective strategies, and strong synergy to improve the quality of modern medication and provide a reliable treatment against new diseases. The collaboration between academia and industry would not only strengthen the efforts to develop and discover new drugs but also avoids a gap in the development process, which may lead translational research to a valley of death. IIUM Press 2021-08-17 Book PeerReviewed application/pdf en http://irep.iium.edu.my/91943/1/Prelim%20pages%202.9.2021.pdf application/pdf en http://irep.iium.edu.my/91943/2/FINAL%20Cover%20Drug%20Development_2.9.2021.pdf application/pdf en http://irep.iium.edu.my/91943/13/91943_Drug%20discovery%20and%20development_prospects%20and%20challenges.pdf Bakhtiar, M. Taher (2021) Drug discovery and development: prospects and challenges. IIUM Press, Kuala Lumpur. ISBN 978-967-491-153-9
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Bakhtiar, M. Taher Drug discovery and development: prospects and challenges
description	Drug discovery and development is a vital process before a new drug can be introduced for clinical use. Undeniably, the process to produce a single drug that is safe for the human body and effectively treat specific disease without any side effects is lengthy and very costly. It starts from the curiosity over an emerging disease or the absence of effective medication and is translated into a scientific and clinical study through various research approaches, such as from jungle-to-bench, from culture-to-vial, and from waste-to-wealth. Since ancient times, humans have produced drugs or medicine from raw plant materials and their extracts to treat various illnesses. Today, the paradigm has shifted from test and trial to a scientific evidence-based approach through experiments and clinical trials. High throughput methods are also crucial tools to speed up the process of drug discovery. Various drugs have been introduced via stringent guidelines and regulations. With the emergence of new diseases, the development of new side effects, and the latest Coronavirus Disease 2019 (COVID-19) outbreak, these experiences and scenarios have taught us how to address the global impact of disease through collaboration and synergistic strategies. As part of the intellectual community, our collective knowledge would be meaningful to contribute to the discovery and development of effective drugs. The main obstacle in drug discovery and development nowadays is related to biological/pharmacological activities and delivery methods. Given this, nanotechnology has provided an impactful approach to drug and vaccine delivery. Certain drugs that possess unwanted side effects can be improved through nanotechnology to reduce their side effect, while their effective constituent can be delivered to the specific site in a very effective manner. Furthermore, the development of nanocarriers, such as nanovesicles, nanoemulsions, and polymers, has become a global interest due to its ability to increase, protect, and encapsulate drugs, ultimately increasing the efficacy of drug delivery. Therefore, drug discovery and development require a continuous supply of innovative ideas, effective strategies, and strong synergy to improve the quality of modern medication and provide a reliable treatment against new diseases. The collaboration between academia and industry would not only strengthen the efforts to develop and discover new drugs but also avoids a gap in the development process, which may lead translational research to a valley of death.
format	Book
author	Bakhtiar, M. Taher
author_facet	Bakhtiar, M. Taher
author_sort	Bakhtiar, M. Taher
title	Drug discovery and development: prospects and challenges
title_short	Drug discovery and development: prospects and challenges
title_full	Drug discovery and development: prospects and challenges
title_fullStr	Drug discovery and development: prospects and challenges
title_full_unstemmed	Drug discovery and development: prospects and challenges
title_sort	drug discovery and development: prospects and challenges
publisher	IIUM Press
publishDate	2021
url	http://irep.iium.edu.my/91943/1/Prelim%20pages%202.9.2021.pdf http://irep.iium.edu.my/91943/2/FINAL%20Cover%20Drug%20Development_2.9.2021.pdf http://irep.iium.edu.my/91943/13/91943_Drug%20discovery%20and%20development_prospects%20and%20challenges.pdf http://irep.iium.edu.my/91943/
_version_	1710675144319434752
score	13.211869

Drug discovery and development: prospects and challenges

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